PSYCH OpenIR  > 中国科学院心理健康重点实验室
药物成瘾诱导相关大脑核团功能和行为改变的DNA甲基化机制
Alternative TitleDNA Methylation Mechanisms Underlying the Changes of Drug Addiction-related Nuclei Function and Addictive Behavior
张建军1; 刘鹏1; 朱宁1; 隋南1
First Author张建军 ; 刘鹏
2013
Source Publication心理科学进展
Correspondent Emailsuin@psych.ac.cn
ISSN1671-3710
Subtype期刊论文
Volume21Issue:6Pages:975-981
Contribution Rank1
Abstract

药物成瘾会导致相关神经环路的结构和功能长期改变。大量新的研究证据表明,在DNA序列不变的情况下,药物成瘾可通过影响不同亚型DNA甲基转移酶(DNMTs)的表达,使脑内多个相关核团发生DNA甲基化以及基因表达的改变,进而导致神经元功能的可塑性变化。因此,DNA甲基化被视作导致成瘾行为长期存在的可能机制之一。结合近几年来的重要发现,本文将重点讨论相关脑区的DNA甲基化在成瘾行为发生发展过程中的作用,以及成瘾药物影响DNA甲基化水平的可能机制,并试图提出可深入的研究展望。

Other Abstract

Drug addiction induces long-term changes in the structure and function of the addiction-related circuitries. Recent studies suggested that drug abuse induced the changes of DNA methylation and gene expression in addiction-related nuclei by modulating the expression of three types of DNA methyltransferases (DNMTs) without changing DNA sequences, which in turn changed the functional neural plasticity. Therefore, DNA methylation is regarded as one of the possible mechanisms underlying persistent addictive behavior. In this review we discuss recent advances in our understanding of how DNA methylation contribute to the addictive behavior and how abusive drugs regulate the DNA methylation, and further proposed a few important directions for future research in the field.

Keyword药物成瘾 DNA甲基化 DNA甲基转移酶(DNMTs)
Subject Area生理心理学/生物心理学
URL查看原文
Indexed ByCSCD
Language中文
Funding Organization中科院心理所青年人才科研启动经费项目(Y2CQ061005),中国科学院知识创新工程项目(KSCX2-EW-R-12),国家自然科学基金(31170988)和国家重点基础研究发展计划(973)(2009CB522002)资助项目.
CSCD IDCSCD:4861689
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15042
Collection中国科学院心理健康重点实验室
Corresponding Author隋南
Affiliation1.中国科学院心理研究所
2.中国科学院心理健康重点实验室
3.中国科学院大学
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
张建军,刘鹏,朱宁,等. 药物成瘾诱导相关大脑核团功能和行为改变的DNA甲基化机制[J]. 心理科学进展,2013,21(6):975-981.
APA 张建军,刘鹏,朱宁,&隋南.(2013).药物成瘾诱导相关大脑核团功能和行为改变的DNA甲基化机制.心理科学进展,21(6),975-981.
MLA 张建军,et al."药物成瘾诱导相关大脑核团功能和行为改变的DNA甲基化机制".心理科学进展 21.6(2013):975-981.
Files in This Item:
File Name/Size DocType Version Access License
药物成瘾诱导相关大脑核团功能和行为改变的(292KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[张建军]'s Articles
[刘鹏]'s Articles
[朱宁]'s Articles
Baidu academic
Similar articles in Baidu academic
[张建军]'s Articles
[刘鹏]'s Articles
[朱宁]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[张建军]'s Articles
[刘鹏]'s Articles
[朱宁]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 药物成瘾诱导相关大脑核团功能和行为改变的DNA甲基化机制_张建军.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.