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转轮运动对小鼠吗啡条件性位置偏爱的建立、消退及重建的影响
Alternative TitleTHE EFFECT OF RUNNING -WHEEL ON THE ESTABLISHMENT, EXTINCTION AND REINSTATEMENT OF MORPHINE CONDITIONED PLACE PREFERENCE IN MICE
李敏1; 田卫平1; 曾坤1; 赵媚1
2012
Source Publication中国药物依赖性杂志
Correspondent Emailzhaomei@psych.ac.cn
ISSN1007-9718
Subtype期刊论文
Volume21Issue:2Pages:111-114
Contribution Rank3
Abstract目的:研究转轮运动对小鼠吗啡条件性位置偏爱(conditioned place preference,CPP)的建立、消退及重建的影响。方法:每次吗啡CPP训练之后,均将动物置于特制的带有转轮的饲养笼内6 h;在CPP测试之后,动物每天在训练箱中自由穿梭,进行CPP消退训练;待CPP消退之后,皮下注射(sc)10 mg.kg-1吗啡点燃。结果:非转轮运动组和转轮运动组的小鼠经过吗啡CPP训练后,在伴药箱的时间较训练前均显著增加(P0.05)。sc吗啡点燃后,非转轮运动组CPP能够重建,而转轮运动组CPP未能重建;结论:转轮运动对吗啡CPP的建立及消退均没有影响,但可以抑制吗啡CPP的重建。; Objective: To detect the effects of running - wheel on the establishment, extinction and reinstatement of morphine CPP in mice. Methods: The animals were put into the special cages with running - wheel apparatus 6 h after morphine CPP training. After the post - conditioning test of CPP, the mice were trained for extinction of morphine CPP by allowing the animals to run cross the CPP chambers freely. Subcutaneous injection of morphine( 10 mg · kg^-1) was used to reinstate the morphine CPP after its extinction. Results:After morphine CPP training, the time spent in the morphine - paired chamber increased significantly in both running - wheel group and non - running - wheel group compared with that in the pre-conditioning test(P 〈0. 001), but there was no significant difference between the two groups(P 〉 0.05). In addition, there was no difference between the two groups at extinction training stage (P 〉 0. 05). However,the extinguished CPP could be reinstated in non- running- wheel group, but not in running- wheel group in priming test. Conclusion.: Running -wheel inhibited the reinstatement of morphine CPP ,whereas had no effects on the establishment and extinction of morphine -induced CPP. KEY WORDS
Keyword吗啡 条件位置性偏爱 消退 重建 点燃 转轮运动
Subject Area生理心理学/生物心理学
URL查看原文
Indexed ByCSCD
Language中文
Funding Organization国家自然科学基金(30870821,81071078)资助
CSCD IDCSCD:4521378
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15163
Collection中国科学院心理健康重点实验室
Corresponding Author赵媚
Affiliation1.温州医学院基因组医学研究院,温州,325000
2.西安交通大学医学院法医系,西安,710061
3.中国科学院心理研究所心理健康重点实验室,北京,100101
Recommended Citation
GB/T 7714
李敏,田卫平,曾坤,等. 转轮运动对小鼠吗啡条件性位置偏爱的建立、消退及重建的影响[J]. 中国药物依赖性杂志,2012,21(2):111-114.
APA 李敏,田卫平,曾坤,&赵媚.(2012).转轮运动对小鼠吗啡条件性位置偏爱的建立、消退及重建的影响.中国药物依赖性杂志,21(2),111-114.
MLA 李敏,et al."转轮运动对小鼠吗啡条件性位置偏爱的建立、消退及重建的影响".中国药物依赖性杂志 21.2(2012):111-114.
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