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Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research
Guo, Liyuan1; Du, Yang1,2; Wang, Jing1
2015-08-06
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
文章类型Article
卷号5期号:0页码:12939
摘要Chronic stress (CS) was reported to associate with many complex diseases and stress-related diseases show strong comorbidity; however, molecular analyses have not been performed to date to evaluate common stress-induced biological processes across these diseases. We utilized networks constructed by genes from seven genetic databases of stress-related diseases or systems to explore the common mechanisms. Genes were connected based on the interaction information of proteins they encode. A common sub-network constructed by 561 overlapping genes and 8863 overlapping edges among seven networks was identified and it provides a common gene module among seven stress-related diseases/systems. This module is significantly overlapped with network that constructed by genes from the CS gene database. 36 genes with high connectivity (hub genes) were identified from seven networks as potential key genes in those diseases/systems, 33 of hub genes were included in the common module. Genes in the common module were enriched in 190 interactive gene ontology (GO) functional clusters which provide potential disease mechanism. In conclusion, by analyzing gene networks we revealed a stress-affected common gene module among seven stress-related diseases/systems which provides insight into the process of stress induction of disease and suggests potential gene and pathway candidates for further research.
收录类别SCI
语种英语
WOS记录号WOS:000359127400001
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15204
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
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Guo, Liyuan,Du, Yang,Wang, Jing. Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research[J]. SCIENTIFIC REPORTS,2015,5(0):12939.
APA Guo, Liyuan,Du, Yang,&Wang, Jing.(2015).Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research.SCIENTIFIC REPORTS,5(0),12939.
MLA Guo, Liyuan,et al."Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research".SCIENTIFIC REPORTS 5.0(2015):12939.
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