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Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research
Guo, Liyuan1; Du, Yang1,2; Wang, Jing1
2015-08-06
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
SubtypeArticle
Volume5Issue:0Pages:12939
AbstractChronic stress (CS) was reported to associate with many complex diseases and stress-related diseases show strong comorbidity; however, molecular analyses have not been performed to date to evaluate common stress-induced biological processes across these diseases. We utilized networks constructed by genes from seven genetic databases of stress-related diseases or systems to explore the common mechanisms. Genes were connected based on the interaction information of proteins they encode. A common sub-network constructed by 561 overlapping genes and 8863 overlapping edges among seven networks was identified and it provides a common gene module among seven stress-related diseases/systems. This module is significantly overlapped with network that constructed by genes from the CS gene database. 36 genes with high connectivity (hub genes) were identified from seven networks as potential key genes in those diseases/systems, 33 of hub genes were included in the common module. Genes in the common module were enriched in 190 interactive gene ontology (GO) functional clusters which provide potential disease mechanism. In conclusion, by analyzing gene networks we revealed a stress-affected common gene module among seven stress-related diseases/systems which provides insight into the process of stress induction of disease and suggests potential gene and pathway candidates for further research.
Indexed BySCI
Language英语
WOS IDWOS:000359127400001
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15204
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
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GB/T 7714
Guo, Liyuan,Du, Yang,Wang, Jing. Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research[J]. SCIENTIFIC REPORTS,2015,5(0):12939.
APA Guo, Liyuan,Du, Yang,&Wang, Jing.(2015).Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research.SCIENTIFIC REPORTS,5(0),12939.
MLA Guo, Liyuan,et al."Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research".SCIENTIFIC REPORTS 5.0(2015):12939.
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