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Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry
Levran, Orna1; Peles, Einat2,3; Randesi, Matthew1; da Rosa, Joel Correa4; Ott, Jurg5,6; Rotrosen, John7,8; Adelson, Miriam1,2,9; Kreek, Mary Jeanne1
2015
发表期刊PHARMACOGENOMICS
ISSN1462-2416
文章类型Article
卷号16期号:12页码:1329-1342
摘要Background: Drug addiction is influenced by genetic factors. Aim: To determine if genetic variants in the serotonergic and adrenergic pathways are associated with heroin and/or cocaine addiction. Subjects & methods: The study examined 140 polymorphisms in 19 genes in 1855 subjects with predominantly European or African ancestries. Results: A total of 38 polymorphisms (13 genes) showed nominal associations, including novel associations in S100A10 (p11) and SLC18A2 (VMAT2). The association of HTR3B SNP rs11606194 with heroin addiction in the European ancestry subgroup remained significant after correction for multiple testing (p(corrected) = 0.04). Conclusion: The study strengthens our previous findings of association of polymorphisms in HTR3A, HTR3B and ADRA1A. The study suggests partial overlap in genetic susceptibility between populations of different ancestry and between heroin and cocaine addiction.
关键词Adra1a Adrenergic Pathway African-american Association Study Cocaine Addiction Genetic Variants Heroin Addiction Htr3a Htr3b S100a10 Serotonergic Pathway Slc18a2 Slc6a4 Stress
收录类别SCI
语种英语
WOS记录号WOS:000361142500001
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15209
专题健康与遗传心理学研究室
作者单位1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA
2.Tel Aviv Elias Sourasky Med Ctr, Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Tel Aviv, Israel
3.Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
4.Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA
5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
6.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA
7.VA New York Harbor Healthcare Syst, New York, NY 10010 USA
8.NYU, Sch Med, New York, NY 10010 USA
9.Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV 89169 USA
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Levran, Orna,Peles, Einat,Randesi, Matthew,et al. Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry[J]. PHARMACOGENOMICS,2015,16(12):1329-1342.
APA Levran, Orna.,Peles, Einat.,Randesi, Matthew.,da Rosa, Joel Correa.,Ott, Jurg.,...&Kreek, Mary Jeanne.(2015).Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry.PHARMACOGENOMICS,16(12),1329-1342.
MLA Levran, Orna,et al."Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry".PHARMACOGENOMICS 16.12(2015):1329-1342.
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