The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation

	The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation
	Li, Xu1,2 ; Xiao, Ya-hui 1,2; Zhao, Qing3,4 ; Leung, Ada W. W.5,6,7; Cheung, Eric F. C.8; Chan, Raymond C. K.1
摘要	We conducted an activation likelihood estimation (ALE) meta-analysis to quantitatively review the existing working memory (WM) training studies that investigated neural activation changes both in healthy individuals and patients with schizophrenia. ALE analysis of studies in healthy individuals indicates a widespread distribution of activation changes with WM training in the frontal and parietal regions, especially the dorsolateral prefrontal cortex, the medial frontal cortex and the precuneus, as well as subcortical regions such as the insula and the striatum. WM training is also accompanied by activation changes in patients with schizophrenia, mainly in the dorsolateral prefrontal cortex, the precuneus and the fusiform gyrus. Our results demonstrate that WM training is accompanied by changes in neural activation patterns in healthy individuals, which may provide the basis for understanding neuroplastic changes in patients with schizophrenia. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	Working memory Training Imaging Activation likelihood estimation meta-analysis Schizophrenia
	2015-08-01
语种	英语
发表期刊	NEUROPSYCHOLOGIA
ISSN	0028-3932
卷号	75 期号:0 页码:149-162
期刊论文类型	Article
收录类别	SSCI
WOS记录号	WOS:000360596700015
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15229
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia 4.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Program, Brisbane, Qld 4111, Australia 5.Univ Alberta, Dept Occupat Therapy, Edmonton, AB, Canada 6.Univ Alberta, Ctr Neurosci, Edmonton, AB, Canada 7.Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON, Canada 8.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
第一作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Li, Xu,Xiao, Ya-hui,Zhao, Qing,et al. The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation[J]. NEUROPSYCHOLOGIA,2015,75(0):149-162.
APA	Li, Xu,Xiao, Ya-hui,Zhao, Qing,Leung, Ada W. W.,Cheung, Eric F. C.,&Chan, Raymond C. K..(2015).The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation.NEUROPSYCHOLOGIA,75(0),149-162.
MLA	Li, Xu,et al."The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation".NEUROPSYCHOLOGIA 75.0(2015):149-162.

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