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The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation
Li, Xu1,2; Xiao, Ya-hui1,2; Zhao, Qing3,4; Leung, Ada W. W.5,6,7; Cheung, Eric F. C.8; Chan, Raymond C. K.1
2015-08-01
Source PublicationNEUROPSYCHOLOGIA
ISSN0028-3932
SubtypeArticle
Volume75Issue:0Pages:149-162
AbstractWe conducted an activation likelihood estimation (ALE) meta-analysis to quantitatively review the existing working memory (WM) training studies that investigated neural activation changes both in healthy individuals and patients with schizophrenia. ALE analysis of studies in healthy individuals indicates a widespread distribution of activation changes with WM training in the frontal and parietal regions, especially the dorsolateral prefrontal cortex, the medial frontal cortex and the precuneus, as well as subcortical regions such as the insula and the striatum. WM training is also accompanied by activation changes in patients with schizophrenia, mainly in the dorsolateral prefrontal cortex, the precuneus and the fusiform gyrus. Our results demonstrate that WM training is accompanied by changes in neural activation patterns in healthy individuals, which may provide the basis for understanding neuroplastic changes in patients with schizophrenia. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordWorking memory Training Imaging Activation likelihood estimation meta-analysis Schizophrenia
Indexed BySSCI
Language英语
WOS IDWOS:000360596700015
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15229
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia
4.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Program, Brisbane, Qld 4111, Australia
5.Univ Alberta, Dept Occupat Therapy, Edmonton, AB, Canada
6.Univ Alberta, Ctr Neurosci, Edmonton, AB, Canada
7.Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON, Canada
8.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Li, Xu,Xiao, Ya-hui,Zhao, Qing,et al. The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation[J]. NEUROPSYCHOLOGIA,2015,75(0):149-162.
APA Li, Xu,Xiao, Ya-hui,Zhao, Qing,Leung, Ada W. W.,Cheung, Eric F. C.,&Chan, Raymond C. K..(2015).The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation.NEUROPSYCHOLOGIA,75(0),149-162.
MLA Li, Xu,et al."The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation".NEUROPSYCHOLOGIA 75.0(2015):149-162.
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