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药物成瘾行为的脑机制及其研究进展
Alternative TitleDRUG ADDICTION BEHAVIOR AND ITS POTENTIAL BIOLOGICAL MECHANISM
隋南; 陈晶
Abstract

药物成瘾是脑内相关核团和细胞在药物反复作用下发生适应性变化的时间依赖过程。成瘾的适应性学说从cAMP水平调节、阿片和多巴胺受体与G蛋白家族耦联等方面,为成瘾形成机制提供了最基本的生物学范畴的理论解释。实验证据在一定程度上揭示了从给药到耐受、敏感、依赖,再到撤药症状的生物变化过程。然而,阐明从急性给药到特殊脑区持续性的适应机制仍然是当前成瘾研究最具挑战性的目标之一。

Other Abstract

Drug addiction is a time-dependent course during which specific nucleus or cells in the brain adapt to repeated exposure to the drugs. The possible mechanism of addiction is explained basically and biologically by adaptation of cAMP pathway signaling, opioid and DA receptor-G protein coupling, etc. Biological changes from the acute effects of drugs to tolerance, sensitization, dependence and withdrawal syndromes have been revealed by much evidence. But at present it is still one of the greatest challenges t...

Keyword药物成瘾 适应性 G蛋白耦联 中脑边缘多巴胺系统 糖皮质激素。
Subject Area生理心理学
2000
Language中文
Source Publication心理学报
ISSN11-2610
Volume32Issue:2Pages:235-240
Indexed ByCSCD ; CSSCI ; 中文核心期刊要目总览
Funding Project中科院生物科学与技术特别支持费 ; 国家自然科学基金!(39970256) ; 中科院留学回国择优资助!(STZ97-2-09)。
CSCD IDCSCD:798016
Citation statistics
Cited Times:7[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/1522
Collection中国科学院心理研究所回溯数据库(1956-2010)
Recommended Citation
GB/T 7714
隋南,陈晶. 药物成瘾行为的脑机制及其研究进展[J]. 心理学报,2000,32(2):235-240.
APA 隋南,&陈晶.(2000).药物成瘾行为的脑机制及其研究进展.心理学报,32(2),235-240.
MLA 隋南,et al."药物成瘾行为的脑机制及其研究进展".心理学报 32.2(2000):235-240.
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