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BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety
Chen, Jie1; Yu, Jing2; Liu, Yujie3; Zhang, Leilei3; Zhang, Jianxin1
2015-08-01
发表期刊JOURNAL OF ANXIETY DISORDERS
ISSN0887-6185
文章类型Article
卷号34期号:0页码:68-75
摘要Etiological research has indicated the gene-environment interaction (G x E) on adolescent anxiety. This study aimed to examine how the BDNF Val 66Met polymorphism interacted with stressful life events and positive mothering to influence youth trait anxiety. The study sample included 780 community adolescents of Chinese Han ethnicity (M = 13.6, 51.3% females). Participants' trait anxiety, exposure to stressful life events, and mother's warmth-reasoning were assessed by self-reported questionnaires. We found that BDNF Val66Met polymorphism significantly moderated the influences of stressful life events and mother's warmth-reasoning on adolescent anxiety. The influences were significantly greater in adolescents carrying one or two Val allele than those with Met/Met genotype. Moreover, the G x E interactions were more consistent with the differential susceptibility than the diathesis-stress model. Adolescents carrying Val allele who were more susceptible to adversity were also more likely to benefit from supportive experiences. These findings provide novel evidence for the role of BDNF Val66Met as a genetic susceptibility modulating the influences of stressful life events and mother's warmth-reasoning on adolescent anxiety. We speculate that BDNF Val66Met may moderate anxious youths' responses to mindfulness-based stress reduction program and family-based treatment targeting the enhancement of positive parenting. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Adolescent anxiety BDNF Val66Met polymorphism Differential susceptibility Gene-environment interaction Positive parenting Stress
收录类别SSCI
语种英语
WOS记录号WOS:000359956400009
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15235
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Maryland Baltimore Cty, Dept Psychol, Baltimore, MD 21228 USA
3.Univ Chinese Acad Sci, Beijing, Peoples R China
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Chen, Jie,Yu, Jing,Liu, Yujie,et al. BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety[J]. JOURNAL OF ANXIETY DISORDERS,2015,34(0):68-75.
APA Chen, Jie,Yu, Jing,Liu, Yujie,Zhang, Leilei,&Zhang, Jianxin.(2015).BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety.JOURNAL OF ANXIETY DISORDERS,34(0),68-75.
MLA Chen, Jie,et al."BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety".JOURNAL OF ANXIETY DISORDERS 34.0(2015):68-75.
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