PSYCH OpenIR  > 中国科学院心理健康重点实验室
BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety
Chen, Jie1; Yu, Jing2; Liu, Yujie3; Zhang, Leilei3; Zhang, Jianxin1
2015-08-01
Source PublicationJOURNAL OF ANXIETY DISORDERS
ISSN0887-6185
SubtypeArticle
Volume34Issue:0Pages:68-75
AbstractEtiological research has indicated the gene-environment interaction (G x E) on adolescent anxiety. This study aimed to examine how the BDNF Val 66Met polymorphism interacted with stressful life events and positive mothering to influence youth trait anxiety. The study sample included 780 community adolescents of Chinese Han ethnicity (M = 13.6, 51.3% females). Participants' trait anxiety, exposure to stressful life events, and mother's warmth-reasoning were assessed by self-reported questionnaires. We found that BDNF Val66Met polymorphism significantly moderated the influences of stressful life events and mother's warmth-reasoning on adolescent anxiety. The influences were significantly greater in adolescents carrying one or two Val allele than those with Met/Met genotype. Moreover, the G x E interactions were more consistent with the differential susceptibility than the diathesis-stress model. Adolescents carrying Val allele who were more susceptible to adversity were also more likely to benefit from supportive experiences. These findings provide novel evidence for the role of BDNF Val66Met as a genetic susceptibility modulating the influences of stressful life events and mother's warmth-reasoning on adolescent anxiety. We speculate that BDNF Val66Met may moderate anxious youths' responses to mindfulness-based stress reduction program and family-based treatment targeting the enhancement of positive parenting. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordAdolescent anxiety BDNF Val66Met polymorphism Differential susceptibility Gene-environment interaction Positive parenting Stress
Indexed BySSCI
Language英语
WOS IDWOS:000359956400009
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15235
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Maryland Baltimore Cty, Dept Psychol, Baltimore, MD 21228 USA
3.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Chen, Jie,Yu, Jing,Liu, Yujie,et al. BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety[J]. JOURNAL OF ANXIETY DISORDERS,2015,34(0):68-75.
APA Chen, Jie,Yu, Jing,Liu, Yujie,Zhang, Leilei,&Zhang, Jianxin.(2015).BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety.JOURNAL OF ANXIETY DISORDERS,34(0),68-75.
MLA Chen, Jie,et al."BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety".JOURNAL OF ANXIETY DISORDERS 34.0(2015):68-75.
Files in This Item:
File Name/Size DocType Version Access License
WOS_000359956400009.(627KB)期刊论文出版稿暂不开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, Jie]'s Articles
[Yu, Jing]'s Articles
[Liu, Yujie]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, Jie]'s Articles
[Yu, Jing]'s Articles
[Liu, Yujie]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, Jie]'s Articles
[Yu, Jing]'s Articles
[Liu, Yujie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.