Institutional Repository of Key Laboratory of Behavioral Science, CAS
Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization | |
Jiang, Lili1,2; Xu, Ting1,2; He, Ye1,2,3; Hou, Xiao-Hui1,2,3; Wang, Jinhui4,5; Cao, Xiao-Yan1,2,4,5; Wei, Gao-Xia1,2; Yang, Zhi1,2; He, Yong6,7,8; Zuo, Xi-Nian1,2,8 | |
第一作者 | Jiang, Lili |
通讯作者邮箱 | zuoxn@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Local functional homogeneity of the human cortex indicates the boundaries between functionally heterogeneous regions and varies remarkably across the cortical mantle. It is unclear whether these variations have the neurobiological and structural basis. We employed structural and resting-state functional magnetic resonance imaging scans from 482 healthy subjects and computed the vertex-wise regional homogeneity of low-frequency fluctuations (2dReHo) and five measures of cortical morphology. We then used these metrics to examine regional variation, morphological association and functional covariance network of 2dReHo. Within the ventral visual stream, increases of 2dReHo reflect reduced complexity of information processing or functional hierarchies. Along the divisions of the prefrontal cortex and posteromedial cortex, the gradients of 2dReHo revealed the hierarchical organization within the two association areas, respectively. Individual differences in 2dReHo are associated with those of cortical morphology, and their whole-brain inter-regional covariation is organized into a functional covariance network, comprising five hierarchically organized modules with hubs of both primary sensory and high-order association areas. These highly reproducible observations suggest that local functional homogeneity has neurobiological relevance that is likely determined by anatomical, developmental and neurocognitive factors and should serve as a neuroimaging marker to investigate the human brain function. |
关键词 | Functional homogeneity Prefrontal cortex Posteromedial cortex Functional hierarchy Structural morphometry Functional covariance Network |
2015-09-01 | |
发表期刊 | BRAIN STRUCTURE & FUNCTION |
ISSN | 1863-2653 |
卷号 | 220期号:5页码:2485-2507 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
WOS记录号 | WOS:000360069200002 |
WOS分区 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/15237 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Zuo, Xi-Nian |
作者单位 | 1.Chinese Acad Sci, Lab Funct Connectome & Dev, Key Lab Behav Sci, Inst Psychol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou 310036, Zhejiang, Peoples R China 5.Hangzhou Normal Univ, Affiliated Hosp, Hangzhou 310036, Zhejiang, Peoples R China 6.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100087, Peoples R China 7.Beijing Normal Univ, Int Data Grp, McGovern Inst Brain Res, Beijing 100087, Peoples R China 8.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100087, Peoples R China |
第一作者单位 | 管理支撑系统 |
通讯作者单位 | 管理支撑系统 |
推荐引用方式 GB/T 7714 | Jiang, Lili,Xu, Ting,He, Ye,et al. Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization[J]. BRAIN STRUCTURE & FUNCTION,2015,220(5):2485-2507. |
APA | Jiang, Lili.,Xu, Ting.,He, Ye.,Hou, Xiao-Hui.,Wang, Jinhui.,...&Zuo, Xi-Nian.(2015).Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization.BRAIN STRUCTURE & FUNCTION,220(5),2485-2507. |
MLA | Jiang, Lili,et al."Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization".BRAIN STRUCTURE & FUNCTION 220.5(2015):2485-2507. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
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