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Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization
Jiang, Lili1,2; Xu, Ting1,2; He, Ye1,2,3; Hou, Xiao-Hui1,2,3; Wang, Jinhui4,5; Cao, Xiao-Yan1,2,4,5; Wei, Gao-Xia1,2; Yang, Zhi1,2; He, Yong6,7,8; Zuo, Xi-Nian1,2,8
2015-09-01
Source PublicationBRAIN STRUCTURE & FUNCTION
ISSN1863-2653
SubtypeArticle
Volume220Issue:5Pages:2485-2507
AbstractLocal functional homogeneity of the human cortex indicates the boundaries between functionally heterogeneous regions and varies remarkably across the cortical mantle. It is unclear whether these variations have the neurobiological and structural basis. We employed structural and resting-state functional magnetic resonance imaging scans from 482 healthy subjects and computed the vertex-wise regional homogeneity of low-frequency fluctuations (2dReHo) and five measures of cortical morphology. We then used these metrics to examine regional variation, morphological association and functional covariance network of 2dReHo. Within the ventral visual stream, increases of 2dReHo reflect reduced complexity of information processing or functional hierarchies. Along the divisions of the prefrontal cortex and posteromedial cortex, the gradients of 2dReHo revealed the hierarchical organization within the two association areas, respectively. Individual differences in 2dReHo are associated with those of cortical morphology, and their whole-brain inter-regional covariation is organized into a functional covariance network, comprising five hierarchically organized modules with hubs of both primary sensory and high-order association areas. These highly reproducible observations suggest that local functional homogeneity has neurobiological relevance that is likely determined by anatomical, developmental and neurocognitive factors and should serve as a neuroimaging marker to investigate the human brain function.
KeywordFunctional homogeneity Prefrontal cortex Posteromedial cortex Functional hierarchy Structural morphometry Functional covariance Network
Indexed BySCI
Language英语
WOS IDWOS:000360069200002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15237
Collection中国科学院行为科学重点实验室
Affiliation1.Chinese Acad Sci, Lab Funct Connectome & Dev, Key Lab Behav Sci, Inst Psychol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou 310036, Zhejiang, Peoples R China
5.Hangzhou Normal Univ, Affiliated Hosp, Hangzhou 310036, Zhejiang, Peoples R China
6.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100087, Peoples R China
7.Beijing Normal Univ, Int Data Grp, McGovern Inst Brain Res, Beijing 100087, Peoples R China
8.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100087, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Lili,Xu, Ting,He, Ye,et al. Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization[J]. BRAIN STRUCTURE & FUNCTION,2015,220(5):2485-2507.
APA Jiang, Lili.,Xu, Ting.,He, Ye.,Hou, Xiao-Hui.,Wang, Jinhui.,...&Zuo, Xi-Nian.(2015).Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization.BRAIN STRUCTURE & FUNCTION,220(5),2485-2507.
MLA Jiang, Lili,et al."Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization".BRAIN STRUCTURE & FUNCTION 220.5(2015):2485-2507.
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