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Anhedonia in schizophrenia: Deficits in both motivation and hedonic capacity
Wang, Jiao1,2; Huang, Jia1; Yang, Xin-Hua1,3; Lui, Simon S. Y.1,4; Cheung, Eric F. C.4; Chan, Raymond C. K.1
2015-10-01
Source PublicationSCHIZOPHRENIA RESEARCH
ISSN0920-9964
SubtypeArticle
Volume168Issue:1-2Pages:465-474
AbstractAnhedonia is one of the core negative symptoms of schizophrenia that affect the ultimate outcome of this disorder. It is unclear whether the motivational or the hedonic component of anhedonia is impaired in patients with schizophrenia. This study examined the deficits in motivation and hedonic capacity in patients with schizophrenia using an Effort-based pleasure experience task (E-pet). Twenty-two schizophrenia patients with prominent negative symptoms, 18 schizophrenia patients without prominent negative symptoms and 29 healthy controls participated in the present study. All of them were administered the E-pet task, which required the participants to make decisions on whether to choose a hard or easy task based on probability and reward magnitude. When making the grip effort allocation decision, schizophrenia patients with prominent negative symptoms were significantly less likely to choose a hard task than healthy controls. As the reward magnitude and the estimated reward value increased, unlike healthy controls, schizophrenia patients with prominent negative symptoms did not increase their hard task choices. They were also significantly less likely to choose a hard task than healthy controls in medium and high probability conditions. When anticipating potential rewards, these patients reported significantly less anticipatory pleasure than healthy controls, even when reward probability and magnitude increased. The pleasure experience rating after obtaining the actual reward was positively correlated with two pleasure experience scales in schizophrenia patients. In conclusion, patients with schizophrenia, especially those with prominent negative symptoms, showed deficits in both reward motivation and anticipatory pleasure experience. (C) 2015 Elsevier B.V. All rights reserved.
KeywordAnhedonia Negative symptoms Effort Motivation Schizophrenia
Indexed BySSCI
Language英语
WOS IDWOS:000361826400067
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15257
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Hunan Agr Univ, Coll Business, Changsha, Hunan, Peoples R China
4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jiao,Huang, Jia,Yang, Xin-Hua,et al. Anhedonia in schizophrenia: Deficits in both motivation and hedonic capacity[J]. SCHIZOPHRENIA RESEARCH,2015,168(1-2):465-474.
APA Wang, Jiao,Huang, Jia,Yang, Xin-Hua,Lui, Simon S. Y.,Cheung, Eric F. C.,&Chan, Raymond C. K..(2015).Anhedonia in schizophrenia: Deficits in both motivation and hedonic capacity.SCHIZOPHRENIA RESEARCH,168(1-2),465-474.
MLA Wang, Jiao,et al."Anhedonia in schizophrenia: Deficits in both motivation and hedonic capacity".SCHIZOPHRENIA RESEARCH 168.1-2(2015):465-474.
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