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Anhedonia in schizophrenia: Deficits in both motivation and hedonic capacity
Wang, Jiao1,2; Huang, Jia1; Yang, Xin-Hua1,3; Lui, Simon S. Y.1,4; Cheung, Eric F. C.4; Chan, Raymond C. K.1
2015-10-01
发表期刊SCHIZOPHRENIA RESEARCH
ISSN0920-9964
文章类型Article
卷号168期号:1-2页码:465-474
摘要Anhedonia is one of the core negative symptoms of schizophrenia that affect the ultimate outcome of this disorder. It is unclear whether the motivational or the hedonic component of anhedonia is impaired in patients with schizophrenia. This study examined the deficits in motivation and hedonic capacity in patients with schizophrenia using an Effort-based pleasure experience task (E-pet). Twenty-two schizophrenia patients with prominent negative symptoms, 18 schizophrenia patients without prominent negative symptoms and 29 healthy controls participated in the present study. All of them were administered the E-pet task, which required the participants to make decisions on whether to choose a hard or easy task based on probability and reward magnitude. When making the grip effort allocation decision, schizophrenia patients with prominent negative symptoms were significantly less likely to choose a hard task than healthy controls. As the reward magnitude and the estimated reward value increased, unlike healthy controls, schizophrenia patients with prominent negative symptoms did not increase their hard task choices. They were also significantly less likely to choose a hard task than healthy controls in medium and high probability conditions. When anticipating potential rewards, these patients reported significantly less anticipatory pleasure than healthy controls, even when reward probability and magnitude increased. The pleasure experience rating after obtaining the actual reward was positively correlated with two pleasure experience scales in schizophrenia patients. In conclusion, patients with schizophrenia, especially those with prominent negative symptoms, showed deficits in both reward motivation and anticipatory pleasure experience. (C) 2015 Elsevier B.V. All rights reserved.
关键词Anhedonia Negative symptoms Effort Motivation Schizophrenia
收录类别SSCI
语种英语
WOS记录号WOS:000361826400067
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15257
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Hunan Agr Univ, Coll Business, Changsha, Hunan, Peoples R China
4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
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Wang, Jiao,Huang, Jia,Yang, Xin-Hua,et al. Anhedonia in schizophrenia: Deficits in both motivation and hedonic capacity[J]. SCHIZOPHRENIA RESEARCH,2015,168(1-2):465-474.
APA Wang, Jiao,Huang, Jia,Yang, Xin-Hua,Lui, Simon S. Y.,Cheung, Eric F. C.,&Chan, Raymond C. K..(2015).Anhedonia in schizophrenia: Deficits in both motivation and hedonic capacity.SCHIZOPHRENIA RESEARCH,168(1-2),465-474.
MLA Wang, Jiao,et al."Anhedonia in schizophrenia: Deficits in both motivation and hedonic capacity".SCHIZOPHRENIA RESEARCH 168.1-2(2015):465-474.
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