Breakdown of the striatal-default mode network loop in schizophrenia

	Breakdown of the striatal-default mode network loop in schizophrenia
	Wang, Xiangpeng 1; Li, Fenghua 1; Zheng, Hanfeng 2; Wang, Weihong 1; Zhang, Wenwen 1; Liu, Zhaoqing 2; Sun, Yujing 1; Chan, Raymond C. K.3 ; Chen, Antao 1
摘要	The striatum has been shown to be a core region in schizophrenia with functional and structural deficits. Previous studies have confirmed the schizophrenia-related functional connectivity between the striatal and cortical regions. However, among these, few studies have attempted to determine the directional flow of the influence. In the present study, we used resting-state fMRI to explore the directed connectivity between the striatum and the cortical regions in schizophrenia. Employing a Granger causality analysis, we observed a significant failure of the directed inhibitory influence of the striatum on the default mode network (DMN) in schizophrenia. Furthermore, the reciprocal influence of the DMN on the striatum was also significantly reduced. These findings provide compelling evidence for a breakdown of the striatum-DMN loop in schizophrenia. This abnormal connectivity could be related to clinical variables. In conclusion, our study suggests that abnormally directed influences between the striatum and the DMN might be a biomarker of schizophrenia and also reveals a potential target for treatment. (C) 2015 Elsevier B.V. All rights reserved.
关键词	Schizophrenia Striatum Default mode network Granger causality analysis Amplitude of low frequency fluctuation Effective connectivity
	2015-10-01
语种	英语
发表期刊	SCHIZOPHRENIA RESEARCH
ISSN	0920-9964
卷号	168 期号:1-2 页码:366-372
期刊论文类型	Article
收录类别	SSCI
WOS记录号	WOS:000361826400052
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15259
专题	中国科学院心理健康重点实验室
作者单位	1.Southwest Univ, Fac Psychol, Minist Educ, Key Lab Cognit & Personal, Chongqing 400715, Peoples R China 2.2nd Peoples Hosp Beibei, Chongqing 400712, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiangpeng,Li, Fenghua,Zheng, Hanfeng,et al. Breakdown of the striatal-default mode network loop in schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2015,168(1-2):366-372.
APA	Wang, Xiangpeng.,Li, Fenghua.,Zheng, Hanfeng.,Wang, Weihong.,Zhang, Wenwen.,...&Chen, Antao.(2015).Breakdown of the striatal-default mode network loop in schizophrenia.SCHIZOPHRENIA RESEARCH,168(1-2),366-372.
MLA	Wang, Xiangpeng,et al."Breakdown of the striatal-default mode network loop in schizophrenia".SCHIZOPHRENIA RESEARCH 168.1-2(2015):366-372.

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