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Genetic variations in the serotonergic system contribute to amygdala volume in humans
Li, Jin1,2,3; Chen, Chunhui1,4; Wu, Karen5; Zhang, Mingxia6; Zhu, Bi1,4; Chen, Chuansheng5; Moyzis, Robert K.7,8; Dong, Qi1,4
AbstractThe amygdala plays a critical role in emotion processing and psychiatric disorders associated with emotion dysfunction. Accumulating evidence suggests that amygdala structure is modulated by serotonin-related genes. However, there is a gap between the small contributions of single loci (less than 1%) and the reported 63-65% heritability of amygdala structure. To understand the "missing heritability," we systematically explored the contribution of serotonin genes on amygdala structure at the gene set level. The present study of 417 healthy Chinese volunteers examined 129 representative polymorphisms in genes from multiple biological mechanisms in the regulation of serotonin neurotransmission. A system-level approach using multiple regression analyses identified that nine SNPs collectively accounted for approximately 8% of the variance in amygdala volume. Permutation analyses showed that the probability of obtaining these findings by chance was low (p = 0.043, permuted for 1000 times). Findings showed that serotonin genes contribute moderately to individual differences in amygdala volume in a healthy Chinese sample. These results indicate that the system-level approach can help us to understand the genetic basis of a complex trait such as amygdala structure.
Keywordserotonin gene amygdala brain structure missing heritability
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WOS IDWOS:000362822100001
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Document Type期刊论文
Affiliation1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
4.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100875, Peoples R China
5.Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA 92697 USA
6.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
7.Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92697 USA
8.Univ Calif Irvine, Inst Genom & Bioinformat, Irvine, CA 92697 USA
Recommended Citation
GB/T 7714
Li, Jin,Chen, Chunhui,Wu, Karen,et al. Genetic variations in the serotonergic system contribute to amygdala volume in humans[J]. FRONTIERS IN NEUROANATOMY,2015,9(0):129.
APA Li, Jin.,Chen, Chunhui.,Wu, Karen.,Zhang, Mingxia.,Zhu, Bi.,...&Dong, Qi.(2015).Genetic variations in the serotonergic system contribute to amygdala volume in humans.FRONTIERS IN NEUROANATOMY,9(0),129.
MLA Li, Jin,et al."Genetic variations in the serotonergic system contribute to amygdala volume in humans".FRONTIERS IN NEUROANATOMY 9.0(2015):129.
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