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Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis
Du, Y.1,2; Gao, L.1,2; Zhang, K.1; Wang, J.1
AbstractThe human IL6 [interleukin 6 (interferon, beta 2)] gene encodes IL-6, a cytokine which not only plays regulatory roles in inflammation, but may be also involved in the progression of cancer. Rs1800796 is a single nucleotide polymorphism (SNP) in the promoter region of IL6, and is associated with IL-6 production. A number of studies have been carried out to determine whether this SNP is associated with cancer risk. However, the results are inconsistent due to small sample sizes of individual studies and limited statistical power. Therefore, to evaluate the overall effect on all investigated cancer types, we conducted a meta-analysis by combining all available studies. Nineteen eligible case-control studies including 23,030 subjects (9,985 cases and 13,045 controls) were included for this meta-analysis. Our study demonstrates that rs1800796 is significantly associated with cancer risk in three genetic models (allele G vs allele C, pooled OR = 1.182, P = 0.009; CG + GG vs CC, pooled OR = 1.333, P = 0.006; CG vs CC, pooled OR = 1.323, P = 0.007). Our meta-analysis suggests that Meta-analysis of IL6 polymorphism and cancer risk.
Keywordrs1800796 Interleukin 6 Cancer risk Meta-analysis
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WOS IDWOS:000364582000020
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Du, Y.,Gao, L.,Zhang, K.,et al. Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(4):13236-13246.
APA Du, Y.,Gao, L.,Zhang, K.,&Wang, J..(2015).Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis.GENETICS AND MOLECULAR RESEARCH,14(4),13236-13246.
MLA Du, Y.,et al."Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis".GENETICS AND MOLECULAR RESEARCH 14.4(2015):13236-13246.
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