Short-term test-retest reliability of resting state fMRI metrics in children with and without attention-deficit/hyperactivity disorder

	Short-term test-retest reliability of resting state fMRI metrics in children with and without attention-deficit/hyperactivity disorder
	Somandepalli, Krishna 1; Kelly, Clare 1; Reiss, Philip T.2,3; Zuo, Xi-Nian4,5 ; Craddock, R. C.6,7; Yan, Chao-Gan1,3,4,5 ; Petkova, Eva 2,3; Castellanos, F. X.1,3; Milham, Michael P.6,7; Di Martino, Adriana
摘要	To date, only one study has examined test-retest reliability of resting state fMRI (R-fMRI) in children, none in clinical developing groups. Here, we assessed short-term test-retest reliability in a sample of 46 children (11-17.9 years) with attention-deficit/hyperactivity disorder (ADHD) and 57 typically developing children (TDC). Our primary test-retest reliability measure was the intraclass correlation coefficient (ICC), quantified for a range of R-fMRI metrics. We aimed to (1) survey reliability within and across diagnostic groups, and (2) compare voxel-wise ICC between groups. We found moderate-to-high ICC across all children and within groups, with higher-order functional networks showing greater ICC. Nearly all R-fMRI metrics exhibited significantly higher ICC in TDC than in children with ADHD for one or more regions. In particular, posterior cingulate and ventral precuneus exhibited group differences in ICC across multiple measures. In the context of overall moderate-to-high test-retest reliability in children, regional differences in ICC related to diagnostic groups likely reflect the underlying pathophysiology for ADHD. Our currently limited understanding of the factors contributing to inter- and intra-subject variability in ADHD underscores the need for large initiatives aimed at examining their impact on test-retest reliability in both clinical and developing populations. (C) 2015 Published by Elsevier Ltd.
关键词	Test-retest Reliability Intraclass Correlation Coefficient Adhd Resting State Fmri Image Intraclass Correlation Coefficient (I2c2)
	2015-10-01
语种	英语
发表期刊	DEVELOPMENTAL COGNITIVE NEUROSCIENCE
ISSN	1878-9293
卷号	15 期号:0 页码:83-93
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000364537300008
引用统计	被引频次：49[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15319
专题	中国科学院行为科学重点实验室
作者单位	1.NYU, Langone Med Ctr, Ctr Child Study, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY 10016 USA 2.NYU, Ctr Child Study, Langone Med Ctr, Div Biostat, New York, NY 10016 USA 3.Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA 4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 6.Child Mind Inst, Ctr Developing Brain, New York, NY 10022 USA 7.Nathan S Kline Inst Psychiat Res, Ctr Biomed Imaging & Neuromodulat, Orangeburg, NY USA
推荐引用方式 GB/T 7714	Somandepalli, Krishna,Kelly, Clare,Reiss, Philip T.,et al. Short-term test-retest reliability of resting state fMRI metrics in children with and without attention-deficit/hyperactivity disorder[J]. DEVELOPMENTAL COGNITIVE NEUROSCIENCE,2015,15(0):83-93.
APA	Somandepalli, Krishna.,Kelly, Clare.,Reiss, Philip T..,Zuo, Xi-Nian.,Craddock, R. C..,...&Di Martino, Adriana.(2015).Short-term test-retest reliability of resting state fMRI metrics in children with and without attention-deficit/hyperactivity disorder.DEVELOPMENTAL COGNITIVE NEUROSCIENCE,15(0),83-93.
MLA	Somandepalli, Krishna,et al."Short-term test-retest reliability of resting state fMRI metrics in children with and without attention-deficit/hyperactivity disorder".DEVELOPMENTAL COGNITIVE NEUROSCIENCE 15.0(2015):83-93.

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