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ADMINISTRATION OF LACTOBACILLUS HELVETICUS NS8 IMPROVES BEHAVIORAL, COGNITIVE, AND BIOCHEMICAL ABERRATIONS CAUSED BY CHRONIC RESTRAINT STRESS
Liang, S.1,2; Wang, T.1; Hu, X.1; Luo, J.3; Li, W.1,2; Wu, X.1,2; Duan, Y.1; Jin, F.
2015-12-03
Source PublicationNEUROSCIENCE
ISSN0306-4522
SubtypeArticle
Volume310Issue:0Pages:561-577
AbstractIncreasing numbers of studies have suggested that the gut microbiota is involved in the pathophysiology of stress-related disorders. Chronic stress can cause behavioral, cognitive, biochemical, and gut microbiota aberrations. Gut bacteria can communicate with the host through the microbiota-gut-brain axis (which mainly includes the immune, neuroendocrine, and neural pathways) to influence brain and behavior. It is hypothesized that administration of probiotics can improve chronic-stress-induced depression. In order to examine this hypothesis, the chronic restraint stress depression model was established in this study. Adult specific pathogen free (SPF) Sprague-Dawley rats were subjected to 21 days of restraint stress followed by behavioral testing (including the sucrose preference test (SPT), elevated-plus maze test, open-field test (OFT), object recognition test (ORT), and object placement test (OPT)) and biochemical analysis. Supplemental Lactobacillus helveticus NS8 was provided every day during stress until the end of experiment, and selective serotonin reuptake inhibitor (SSRI) citalopram (CIT) served as a positive control. Results showed that L. helveticus NS8 improved chronic restraint stress-induced behavioral (anxiety and depression) and cognitive dysfunction, showing an effect similar to and better than that of CIT. L. helveticus NS8 also resulted in lower plasma corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels, higher plasma interleukin-10 (IL-10) levels, restored hippocampal serotonin (5-HT) and norepinephrine (NE) levels, and more hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression than in chronic stress rats. Taken together, these results indicate an anti-depressant effect of L. helveticus NS8 in rats subjected to chronic restraint stress depression and that this effect could be due to the microbiota-gut-brain axis. They also suggest the therapeutic potential of L. helveticus NS8 in stress-related and possibly other kinds of depression. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
KeywordLactobacillus helveticus chronic restraint stress depression microbiota-gut-brain axis BDNF serotonin
Indexed BySCI
Language英语
WOS IDWOS:000364149800045
Citation statistics
Cited Times:78[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15324
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Sichuan Normal Univ, Teacher Educ Coll, Chengdu, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Liang, S.,Wang, T.,Hu, X.,et al. ADMINISTRATION OF LACTOBACILLUS HELVETICUS NS8 IMPROVES BEHAVIORAL, COGNITIVE, AND BIOCHEMICAL ABERRATIONS CAUSED BY CHRONIC RESTRAINT STRESS[J]. NEUROSCIENCE,2015,310(0):561-577.
APA Liang, S..,Wang, T..,Hu, X..,Luo, J..,Li, W..,...&Jin, F..(2015).ADMINISTRATION OF LACTOBACILLUS HELVETICUS NS8 IMPROVES BEHAVIORAL, COGNITIVE, AND BIOCHEMICAL ABERRATIONS CAUSED BY CHRONIC RESTRAINT STRESS.NEUROSCIENCE,310(0),561-577.
MLA Liang, S.,et al."ADMINISTRATION OF LACTOBACILLUS HELVETICUS NS8 IMPROVES BEHAVIORAL, COGNITIVE, AND BIOCHEMICAL ABERRATIONS CAUSED BY CHRONIC RESTRAINT STRESS".NEUROSCIENCE 310.0(2015):561-577.
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