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Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders
作者: Yang, Xin-hua1,2; Wang Yi(王毅)1; Huang, Jia1; Zhu, Cui-ying2; Liu, Xiao-qun5; Cheung, Eric F. C.4; Xie, Guang-rong3; Chen, ChuQiao(陈楚侨)1
文章类型: Article
关键词: Major depressive disorder ; Cortical thickness ; Caudate-cortical network ; Anhedonia ; Parietal gyrus
刊名: PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN号: 0925-4927
出版日期: 2015-10-30
卷号: 234, 期号:1, 页码:144-151
收录类别: SCI
英文摘要: Cerebral morphological abnormalities in major depressive disorder (MDD) may be modulated by antidepressant treatment and course of illness in chronic medicated patients. The present study examined cortical thickness in patients with untreated first-episode MDD to elucidate the early pathophysiology of this illness. Here, we examined cortical thickness in patients with first-episode MDD (N=27) and healthy controls (N=27) using an automated surface-based method (in FreeSurfer). By assessing the correlation between caudate volume and cortical thickness at each vertex on the cortical surface, a caudate-cortical network was obtained for each group. Subsequent analysis was performed to assess the effect of anhedonia by the Temporal Experience of Pleasure Scale. We observed increased cortical thickness at the right orbital frontal cortex and the left inferior parietal gyrus in MDD patients compared with healthy controls. Furthermore, morphometric correlational analysis using cortical thickness measurement revealed increased caudate-cortical connectivity in the bilateral superior parietal gyrus in MDD patients. All changes were not related to anhedonia. These preliminary findings may reflect disorder manifestation close to illness onset and may provide insight into the early neurobiology of MDD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
语种: 英语
WOS记录号: WOS:000365221500019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.psych.ac.cn/handle/311026/15328
Appears in Collections:中国科学院心理健康重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Hunan Agr Univ, Coll Business, Changsha, Hunan, Peoples R China
3.Cent S Univ, Natl Technol Inst Psychiat, Key Lab Psychiat & Mental Hlth Hunan Prov, Mental Hlth Inst,Xiangya Hosp 2, Changsha, Hunan, Peoples R China
4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
5.Cent S Univ, Sch Publ Hlth, Changsha, Hunan, Peoples R China

Recommended Citation:
Yang, Xin-hua,Wang, Yi,Huang, Jia,et al. Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,234(1):144-151.
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