Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders

	Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders
	Yang, Xin-hua 1,2; Wang, Yi1 ; Huang, Jia1 ; Zhu, Cui-ying 2; Liu, Xiao-qun 5; Cheung, Eric F. C.4; Xie, Guang-rong 3; Chan, Raymond C. K.1
摘要	Cerebral morphological abnormalities in major depressive disorder (MDD) may be modulated by antidepressant treatment and course of illness in chronic medicated patients. The present study examined cortical thickness in patients with untreated first-episode MDD to elucidate the early pathophysiology of this illness. Here, we examined cortical thickness in patients with first-episode MDD (N=27) and healthy controls (N=27) using an automated surface-based method (in FreeSurfer). By assessing the correlation between caudate volume and cortical thickness at each vertex on the cortical surface, a caudate-cortical network was obtained for each group. Subsequent analysis was performed to assess the effect of anhedonia by the Temporal Experience of Pleasure Scale. We observed increased cortical thickness at the right orbital frontal cortex and the left inferior parietal gyrus in MDD patients compared with healthy controls. Furthermore, morphometric correlational analysis using cortical thickness measurement revealed increased caudate-cortical connectivity in the bilateral superior parietal gyrus in MDD patients. All changes were not related to anhedonia. These preliminary findings may reflect disorder manifestation close to illness onset and may provide insight into the early neurobiology of MDD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
关键词	Major depressive disorder Cortical thickness Caudate-cortical network Anhedonia Parietal gyrus
	2015-10-30
语种	英语
发表期刊	PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN	0925-4927
卷号	234 期号:1 页码:144-151
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000365221500019
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15328
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Hunan Agr Univ, Coll Business, Changsha, Hunan, Peoples R China 3.Cent S Univ, Natl Technol Inst Psychiat, Key Lab Psychiat & Mental Hlth Hunan Prov, Mental Hlth Inst,Xiangya Hosp 2, Changsha, Hunan, Peoples R China 4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 5.Cent S Univ, Sch Publ Hlth, Changsha, Hunan, Peoples R China
第一作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Yang, Xin-hua,Wang, Yi,Huang, Jia,et al. Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,234(1):144-151.
APA	Yang, Xin-hua.,Wang, Yi.,Huang, Jia.,Zhu, Cui-ying.,Liu, Xiao-qun.,...&Chan, Raymond C. K..(2015).Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders.PSYCHIATRY RESEARCH-NEUROIMAGING,234(1),144-151.
MLA	Yang, Xin-hua,et al."Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders".PSYCHIATRY RESEARCH-NEUROIMAGING 234.1(2015):144-151.

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