PSYCH OpenIR  > 中国科学院心理健康重点实验室
Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders
Yang, Xin-hua1,2; Wang, Yi1; Huang, Jia1; Zhu, Cui-ying2; Liu, Xiao-qun5; Cheung, Eric F. C.4; Xie, Guang-rong3; Chan, Raymond C. K.1
2015-10-30
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
SubtypeArticle
Volume234Issue:1Pages:144-151
AbstractCerebral morphological abnormalities in major depressive disorder (MDD) may be modulated by antidepressant treatment and course of illness in chronic medicated patients. The present study examined cortical thickness in patients with untreated first-episode MDD to elucidate the early pathophysiology of this illness. Here, we examined cortical thickness in patients with first-episode MDD (N=27) and healthy controls (N=27) using an automated surface-based method (in FreeSurfer). By assessing the correlation between caudate volume and cortical thickness at each vertex on the cortical surface, a caudate-cortical network was obtained for each group. Subsequent analysis was performed to assess the effect of anhedonia by the Temporal Experience of Pleasure Scale. We observed increased cortical thickness at the right orbital frontal cortex and the left inferior parietal gyrus in MDD patients compared with healthy controls. Furthermore, morphometric correlational analysis using cortical thickness measurement revealed increased caudate-cortical connectivity in the bilateral superior parietal gyrus in MDD patients. All changes were not related to anhedonia. These preliminary findings may reflect disorder manifestation close to illness onset and may provide insight into the early neurobiology of MDD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
KeywordMajor depressive disorder Cortical thickness Caudate-cortical network Anhedonia Parietal gyrus
Indexed BySCI
Language英语
WOS IDWOS:000365221500019
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15328
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Hunan Agr Univ, Coll Business, Changsha, Hunan, Peoples R China
3.Cent S Univ, Natl Technol Inst Psychiat, Key Lab Psychiat & Mental Hlth Hunan Prov, Mental Hlth Inst,Xiangya Hosp 2, Changsha, Hunan, Peoples R China
4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
5.Cent S Univ, Sch Publ Hlth, Changsha, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Yang, Xin-hua,Wang, Yi,Huang, Jia,et al. Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,234(1):144-151.
APA Yang, Xin-hua.,Wang, Yi.,Huang, Jia.,Zhu, Cui-ying.,Liu, Xiao-qun.,...&Chan, Raymond C. K..(2015).Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders.PSYCHIATRY RESEARCH-NEUROIMAGING,234(1),144-151.
MLA Yang, Xin-hua,et al."Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders".PSYCHIATRY RESEARCH-NEUROIMAGING 234.1(2015):144-151.
Files in This Item:
File Name/Size DocType Version Access License
WOS_000365221500019.(799KB)期刊论文出版稿暂不开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Xin-hua]'s Articles
[Wang, Yi]'s Articles
[Huang, Jia]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Xin-hua]'s Articles
[Wang, Yi]'s Articles
[Huang, Jia]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Xin-hua]'s Articles
[Wang, Yi]'s Articles
[Huang, Jia]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.