The neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study

	The neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study
	Zou, Lai-quan 1,2; Geng, Fu-lei 1,2; Liu, Wen-hua 3; Wei, Xin-hua 4; Jiang, Xin-qing 4; Wang, Yi1 ; Shi, Hai-song 1,2,5; Lui, Simon S. Y.6; Cheung, Eric F. C.6; Chan, Raymond C. K.1
摘要	Previous studies have established a linkage between olfactory deficits and negative symptoms in schizophrenia. However, it is not known whether olfactory function is associated with hedonic traits in individuals with schizotypy. Seventeen individuals with schizotypy and 18 age- and sex-matched controls participated in this study. Hedonic traits were assessed with the Chapman Scales for Physical and Social Anhedonia (CSAS and CPAS). Olfactory function was assessed with the Sniffin' Stick Test (olfactory threshold, odour discrimination and odour identification). All participants undertook a structural imaging scan for grey matter volume measurements. Individuals with schizotypy had significantly higher CSAS and CPAS scores than healthy controls. They had normal olfactory function. Their odour identification ability was inversely correlated with physical and social anhedonia. The volume of the right parahippocampal gyrus was positively associated with odour identification ability, and negatively associated with physical and social anhedonia. Furthermore, mediation analysis suggested that odour identification ability influences anhedonia through its effect on the right parahippocampal gyrus. No such relationship was found in controls. These findings suggest that there is a relationship between odour identification and anhedonia in individuals with schizotypy, and the association may be mediated by parahippocampal gyrus volume. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
关键词	Olfaction Anhedonia Schizotypy Imaging
	2015-11-30
语种	英语
发表期刊	PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN	0925-4927
卷号	234 期号:2 页码:202-207
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000365053600007
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15338
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Guangzhou Med Univ, Fac Hlth Management, Guangzhou, Guangdong, Peoples R China 4.Guangzhou First Peoples Hosp, Dept Radiol, Guangzhou, Guangdong, Peoples R China 5.North China Elect Power Univ, Beijing, Peoples R China 6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
第一作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Zou, Lai-quan,Geng, Fu-lei,Liu, Wen-hua,et al. The neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,234(2):202-207.
APA	Zou, Lai-quan.,Geng, Fu-lei.,Liu, Wen-hua.,Wei, Xin-hua.,Jiang, Xin-qing.,...&Chan, Raymond C. K..(2015).The neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study.PSYCHIATRY RESEARCH-NEUROIMAGING,234(2),202-207.
MLA	Zou, Lai-quan,et al."The neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study".PSYCHIATRY RESEARCH-NEUROIMAGING 234.2(2015):202-207.

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