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The neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study
Zou, Lai-quan1,2; Geng, Fu-lei1,2; Liu, Wen-hua3; Wei, Xin-hua4; Jiang, Xin-qing4; Wang, Yi1; Shi, Hai-song1,2,5; Lui, Simon S. Y.6; Cheung, Eric F. C.6; Chan, Raymond C. K.1
2015-11-30
发表期刊PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
文章类型Article
卷号234期号:2页码:202-207
摘要Previous studies have established a linkage between olfactory deficits and negative symptoms in schizophrenia. However, it is not known whether olfactory function is associated with hedonic traits in individuals with schizotypy. Seventeen individuals with schizotypy and 18 age- and sex-matched controls participated in this study. Hedonic traits were assessed with the Chapman Scales for Physical and Social Anhedonia (CSAS and CPAS). Olfactory function was assessed with the Sniffin' Stick Test (olfactory threshold, odour discrimination and odour identification). All participants undertook a structural imaging scan for grey matter volume measurements. Individuals with schizotypy had significantly higher CSAS and CPAS scores than healthy controls. They had normal olfactory function. Their odour identification ability was inversely correlated with physical and social anhedonia. The volume of the right parahippocampal gyrus was positively associated with odour identification ability, and negatively associated with physical and social anhedonia. Furthermore, mediation analysis suggested that odour identification ability influences anhedonia through its effect on the right parahippocampal gyrus. No such relationship was found in controls. These findings suggest that there is a relationship between odour identification and anhedonia in individuals with schizotypy, and the association may be mediated by parahippocampal gyrus volume. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
关键词Olfaction Anhedonia Schizotypy Imaging
收录类别SCI
语种英语
WOS记录号WOS:000365053600007
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15338
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Guangzhou Med Univ, Fac Hlth Management, Guangzhou, Guangdong, Peoples R China
4.Guangzhou First Peoples Hosp, Dept Radiol, Guangzhou, Guangdong, Peoples R China
5.North China Elect Power Univ, Beijing, Peoples R China
6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Zou, Lai-quan,Geng, Fu-lei,Liu, Wen-hua,et al. The neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,234(2):202-207.
APA Zou, Lai-quan.,Geng, Fu-lei.,Liu, Wen-hua.,Wei, Xin-hua.,Jiang, Xin-qing.,...&Chan, Raymond C. K..(2015).The neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study.PSYCHIATRY RESEARCH-NEUROIMAGING,234(2),202-207.
MLA Zou, Lai-quan,et al."The neural basis of olfactory function and its relationship with anhedonia in individuals with schizotypy: An exploratory study".PSYCHIATRY RESEARCH-NEUROIMAGING 234.2(2015):202-207.
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