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Was it a pain or a sound? Across-species variability in sensory sensitivity
Hu, Li1,2,3,4; Xia, Xiaolei L.1,2; Peng, Weiwei W.1,2; Su, Wenxin X.1,2; Luo, Fei4; Yuan, Hong1,2; Chen, Antao T.1,2; Liang, Meng3; Iannetti, Giandomenico3
2015-12-01
Source PublicationPAIN
ISSN0304-3959
SubtypeArticle
Volume156Issue:12Pages:2449-2457
AbstractNatural selection has shaped the physiological properties of sensory systems across species, yielding large variations in their sensitivity. Here, we used laser stimulation of skin nociceptors, a widely used technique to investigate pain in rats and humans, to provide a vivid example of how ignoring these variations can lead to serious misconceptions in sensory neuroscience. In 6 experiments, we characterized and compared the physiological properties of the electrocortical responses elicited by laser stimulation in rats and humans. We recorded the electroencephalogram from the surface of the brain in freely moving rats and from the scalp in healthy humans. Laser stimuli elicited 2 temporally distinct responses, traditionally interpreted as reflecting the concomitant activation of different populations of nociceptors with different conduction velocities: small-myelinated Ad-fibres and unmyelinated C-fibres. Our results show that this interpretation is valid in humans, but not in rats. Indeed, the early response recorded in rats does not reflect the activation of the somatosensory system, but of the auditory system by laser-generated ultrasounds. These results have wide implications: retrospectively, as they prompt for a reconsideration of a large number of previous interpretations of electrocortical rat recordings in basic, preclinical, and pharmacological research, and prospectively, as they will allow recording truly pain-related cortical responses in rats.
KeywordSensory sensitivity A delta-fibres C-fibres Electroencephalogram (EEG) Rats Humans
DOI10.1097/j.pain.0000000000000316
Indexed BySCI
Language英语
WOS Research AreaAnesthesiology ; Neurosciences & Neurology
WOS SubjectAnesthesiology ; Clinical Neurology ; Neurosciences
WOS IDWOS:000365598300010
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordPRIMARY SOMATOSENSORY CORTEX ; LASER-EVOKED-POTENTIALS ; FIELD POTENTIALS ; CO2-LASER STIMULATION ; INFRARED-LASER ; A-DELTA ; STIMULUS SALIENCY ; BRAIN POTENTIALS ; CONSCIOUS RATS ; HEAT STIMULI
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15361
Collection中国科学院心理健康重点实验室
Affiliation1.Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing 400715, Peoples R China
2.Southwest Univ, Fac Psychol, Chongqing 400715, Peoples R China
3.UCL, Dept Neurosci Physiol & Pharmacol, London, England
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Hu, Li,Xia, Xiaolei L.,Peng, Weiwei W.,et al. Was it a pain or a sound? Across-species variability in sensory sensitivity[J]. PAIN,2015,156(12):2449-2457.
APA Hu, Li.,Xia, Xiaolei L..,Peng, Weiwei W..,Su, Wenxin X..,Luo, Fei.,...&Iannetti, Giandomenico.(2015).Was it a pain or a sound? Across-species variability in sensory sensitivity.PAIN,156(12),2449-2457.
MLA Hu, Li,et al."Was it a pain or a sound? Across-species variability in sensory sensitivity".PAIN 156.12(2015):2449-2457.
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