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Was it a pain or a sound? Across-species variability in sensory sensitivity
Hu, Li1,2,3,4; Xia, Xiaolei L.1,2; Peng, Weiwei W.1,2; Su, Wenxin X.1,2; Luo, Fei4; Yuan, Hong1,2; Chen, Antao T.1,2; Liang, Meng3; Iannetti, Giandomenico3
2015-12-01
发表期刊PAIN
ISSN0304-3959
文章类型Article
卷号156期号:12页码:2449-2457
摘要Natural selection has shaped the physiological properties of sensory systems across species, yielding large variations in their sensitivity. Here, we used laser stimulation of skin nociceptors, a widely used technique to investigate pain in rats and humans, to provide a vivid example of how ignoring these variations can lead to serious misconceptions in sensory neuroscience. In 6 experiments, we characterized and compared the physiological properties of the electrocortical responses elicited by laser stimulation in rats and humans. We recorded the electroencephalogram from the surface of the brain in freely moving rats and from the scalp in healthy humans. Laser stimuli elicited 2 temporally distinct responses, traditionally interpreted as reflecting the concomitant activation of different populations of nociceptors with different conduction velocities: small-myelinated Ad-fibres and unmyelinated C-fibres. Our results show that this interpretation is valid in humans, but not in rats. Indeed, the early response recorded in rats does not reflect the activation of the somatosensory system, but of the auditory system by laser-generated ultrasounds. These results have wide implications: retrospectively, as they prompt for a reconsideration of a large number of previous interpretations of electrocortical rat recordings in basic, preclinical, and pharmacological research, and prospectively, as they will allow recording truly pain-related cortical responses in rats.
关键词Sensory sensitivity A delta-fibres C-fibres Electroencephalogram (EEG) Rats Humans
DOI10.1097/j.pain.0000000000000316
收录类别SCI
语种英语
WOS研究方向Anesthesiology ; Neurosciences & Neurology
WOS类目Anesthesiology ; Clinical Neurology ; Neurosciences
WOS记录号WOS:000365598300010
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]PRIMARY SOMATOSENSORY CORTEX ; LASER-EVOKED-POTENTIALS ; FIELD POTENTIALS ; CO2-LASER STIMULATION ; INFRARED-LASER ; A-DELTA ; STIMULUS SALIENCY ; BRAIN POTENTIALS ; CONSCIOUS RATS ; HEAT STIMULI
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15361
专题中国科学院心理健康重点实验室
作者单位1.Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing 400715, Peoples R China
2.Southwest Univ, Fac Psychol, Chongqing 400715, Peoples R China
3.UCL, Dept Neurosci Physiol & Pharmacol, London, England
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Hu, Li,Xia, Xiaolei L.,Peng, Weiwei W.,et al. Was it a pain or a sound? Across-species variability in sensory sensitivity[J]. PAIN,2015,156(12):2449-2457.
APA Hu, Li.,Xia, Xiaolei L..,Peng, Weiwei W..,Su, Wenxin X..,Luo, Fei.,...&Iannetti, Giandomenico.(2015).Was it a pain or a sound? Across-species variability in sensory sensitivity.PAIN,156(12),2449-2457.
MLA Hu, Li,et al."Was it a pain or a sound? Across-species variability in sensory sensitivity".PAIN 156.12(2015):2449-2457.
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