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The neural basis of impulsive discounting in pathological gamblers
Miedl, Stephan F.1; Wiswede, Daniel2; Marco-Pallares, Josep3,4; Ye, Zheng5; Fehr, Thorsten6; Herrmann, Manfred6; Muente, Thomas F.2,7
2015-12-01
Source PublicationBRAIN IMAGING AND BEHAVIOR
ISSN1931-7557
SubtypeArticle
Volume9Issue:4Pages:887-898
AbstractPathological gambling is thought to result from a shift of balance between two competing neurobiological mechanisms: on the one hand the reward system involved in the regulation of the urge to get rewards and on the other hand the top-down control system. Fifteen pathological gamblers (PG) and fifteen healthy controls (HC) were studied in an event-related functional magnetic resonance imaging experiment where participants had to choose either a smaller, but immediately available monetary reward (SIR) or a larger delayed reward (LDR). We examined contrasts between LDR and SIR decisions. Additionally, we contrasted choices near the individual indifference point (indifferent decisions) and clear SIR or LDR choices (sure decisions). Behavioral data confirmed former results of steeper discount rates in PG. Contrasting choices of LDR vs. SIR showed widespread bilateral activations in PG, including postcentral gyrus, thalamus, superior/medial frontal gyrus and cingulate gyrus, whereas HC demonstrated only focal left-sided pre/postcentral activity. Forgoing an immediate reward thus recruits a widespread brain network including typical control areas. Indifferent vs. sure decisions were associated with widespread activation in PG, including the bilateral fronto-parietal cortex, insula, anterior cingulate gyrus, and striatum, whereas in HC, only bilateral frontal cortex and insula were activated. The reverse contrast demonstrated more activity for sure decisions in the cingulate gyrus, insula, and medial frontal gyrus in HC, whereas PG showed inferior parietal and superior temporal activity. The present study demonstrates that pathological gambling is associated with a shift in the interplay between a prefrontal-parietal control network and a brain network involved in immediate reward consumption.
KeywordDelay discounting Intertemporal choice Pathological gambling fMRI Reward
DOI10.1007/s11682-015-9352-1
Indexed BySCI ; SSCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000365755500022
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordCATECHOL-O-METHYLTRANSFERASE ; INTERTEMPORAL CHOICE ; DELAYED REWARDS ; DECISION-MAKING ; GAMBLING SEVERITY ; SUBJECTIVE VALUE ; BRAIN ACTIVITY ; HIGH-RATES ; PROBABILITY ; ALCOHOL
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Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15368
Collection健康与遗传心理学研究室
Affiliation1.Salzburg Univ, Dept Psychol, A-5020 Salzburg, Austria
2.Univ Lubeck, Dept Neurol, D-23538 Lubeck, Germany
3.Inst Invest Biomed Bellvitge IDIBELL, Barcelona, Spain
4.Univ Barcelona, Dept Basic Psychol, Barcelona, Germany
5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
6.Univ Bremen, Dept Neuropsychol, D-28359 Bremen, Germany
7.Univ Lubeck, Inst Psychol 2, Lubeck, Germany
Recommended Citation
GB/T 7714
Miedl, Stephan F.,Wiswede, Daniel,Marco-Pallares, Josep,et al. The neural basis of impulsive discounting in pathological gamblers[J]. BRAIN IMAGING AND BEHAVIOR,2015,9(4):887-898.
APA Miedl, Stephan F..,Wiswede, Daniel.,Marco-Pallares, Josep.,Ye, Zheng.,Fehr, Thorsten.,...&Muente, Thomas F..(2015).The neural basis of impulsive discounting in pathological gamblers.BRAIN IMAGING AND BEHAVIOR,9(4),887-898.
MLA Miedl, Stephan F.,et al."The neural basis of impulsive discounting in pathological gamblers".BRAIN IMAGING AND BEHAVIOR 9.4(2015):887-898.
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