Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder

doi:10.1016/j.pscychresns.2015.10.005

	Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder
	Peng, Ziwen 1,2,3; Li, Gang 1; Shi, Feng 1; Shi, Changzheng 4; Yang, Qiong 5; Chan, Raymond C. K.6 ; Shen, Dinggang 1,2,7
摘要	Obsessive-compulsive disorder (OCD) is considered to be associated with atypical brain asymmetry. However, no study has examined the asymmetry in OCD from the perspective of cortical morphometry. This study is aimed to describe the characteristics of cortical asymmetry in OCD patients, and to investigate whether these features exist in their unaffected siblings - a vital step in identifying putative endophenotypes for OCD. A total of 48 subjects (16 OCD patients, 16 unaffected siblings, and 16 matched controls) were recruited who had complete magnetic resonance imaging scans. Left-right hemispheric asymmetries of cortical thickness were measured using a surface-based threshold-free cluster enhancement method. OCD patients and siblings both showed leftward asymmetries of cortical thickness in the anterior cingulate cortex (ACC), which showed a significant positive correlation with compulsive subscale scores. In addition, siblings and healthy controls showed significantly decreased leftward asymmetries in the orbitofrontal cortex (OFC), and the decreased leftward bias in the OFC was accompanied by lower scales on the Yale-Brown Obsessive-Compulsive Scale. To sum up, leftward asymmetries of cortical thickness in the ACC may represent an endophenotype of increased hereditary risk for OCD, while decreased leftward asymmetries of cortical thickness in the OFC may represent a protective factor. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
关键词	Cortical thickness Obsessive-compulsive disorder Endophenotype Hemispheric asymmetry Siblings
	2015-12-30
语种	英语
DOI	10.1016/j.pscychresns.2015.10.005
发表期刊	PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN	0925-4927
卷号	234 期号:3 页码:346-351
期刊论文类型	Article
收录类别	SCI
WOS关键词	SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; HEMISPHERIC ASYMMETRIES ; ANTERIOR CINGULATE ; MATTER ABNORMALITIES ; BRAIN ; INVENTORY ; THICKNESS ; ATTENTION ; VERSION
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Neuroimaging ; Psychiatry
WOS记录号	WOS:000366011200009
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15382
专题	中国科学院心理健康重点实验室
作者单位	1.S China Normal Univ, Sch Psychol, Ctr Studies Psychol Applicat, Guangzhou, Guangdong, Peoples R China 2.Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA 3.Univ N Carolina, BRIC, Chapel Hill, NC 27599 USA 4.Jinan Univ, Affiliated Hosp 1, Med Imaging Ctr, Guangzhou, Guangdong, Peoples R China 5.Guangzhou Psychiat Hosp, Guangzhou, Guangdong, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 7.Korea Univ, Dept Brain & Cognit Engn, Seoul, South Korea
推荐引用方式 GB/T 7714	Peng, Ziwen,Li, Gang,Shi, Feng,et al. Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,234(3):346-351.
APA	Peng, Ziwen.,Li, Gang.,Shi, Feng.,Shi, Changzheng.,Yang, Qiong.,...&Shen, Dinggang.(2015).Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder.PSYCHIATRY RESEARCH-NEUROIMAGING,234(3),346-351.
MLA	Peng, Ziwen,et al."Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder".PSYCHIATRY RESEARCH-NEUROIMAGING 234.3(2015):346-351.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS_000366011200009.（698KB）	期刊论文	出版稿	暂不开放	CC BY-NC-SA	请求全文