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Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder
Peng, Ziwen1,2,3; Li, Gang1; Shi, Feng1; Shi, Changzheng4; Yang, Qiong5; Chan, Raymond C. K.6; Shen, Dinggang1,2,7
2015-12-30
发表期刊PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
文章类型Article
卷号234期号:3页码:346-351
摘要Obsessive-compulsive disorder (OCD) is considered to be associated with atypical brain asymmetry. However, no study has examined the asymmetry in OCD from the perspective of cortical morphometry. This study is aimed to describe the characteristics of cortical asymmetry in OCD patients, and to investigate whether these features exist in their unaffected siblings - a vital step in identifying putative endophenotypes for OCD. A total of 48 subjects (16 OCD patients, 16 unaffected siblings, and 16 matched controls) were recruited who had complete magnetic resonance imaging scans. Left-right hemispheric asymmetries of cortical thickness were measured using a surface-based threshold-free cluster enhancement method. OCD patients and siblings both showed leftward asymmetries of cortical thickness in the anterior cingulate cortex (ACC), which showed a significant positive correlation with compulsive subscale scores. In addition, siblings and healthy controls showed significantly decreased leftward asymmetries in the orbitofrontal cortex (OFC), and the decreased leftward bias in the OFC was accompanied by lower scales on the Yale-Brown Obsessive-Compulsive Scale. To sum up, leftward asymmetries of cortical thickness in the ACC may represent an endophenotype of increased hereditary risk for OCD, while decreased leftward asymmetries of cortical thickness in the OFC may represent a protective factor. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
关键词Cortical thickness Obsessive-compulsive disorder Endophenotype Hemispheric asymmetry Siblings
DOI10.1016/j.pscychresns.2015.10.005
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Clinical Neurology ; Neuroimaging ; Psychiatry
WOS记录号WOS:000366011200009
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; HEMISPHERIC ASYMMETRIES ; ANTERIOR CINGULATE ; MATTER ABNORMALITIES ; BRAIN ; INVENTORY ; THICKNESS ; ATTENTION ; VERSION
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15382
专题中国科学院心理健康重点实验室
作者单位1.S China Normal Univ, Sch Psychol, Ctr Studies Psychol Applicat, Guangzhou, Guangdong, Peoples R China
2.Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
3.Univ N Carolina, BRIC, Chapel Hill, NC 27599 USA
4.Jinan Univ, Affiliated Hosp 1, Med Imaging Ctr, Guangzhou, Guangdong, Peoples R China
5.Guangzhou Psychiat Hosp, Guangzhou, Guangdong, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
7.Korea Univ, Dept Brain & Cognit Engn, Seoul, South Korea
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Peng, Ziwen,Li, Gang,Shi, Feng,et al. Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,234(3):346-351.
APA Peng, Ziwen.,Li, Gang.,Shi, Feng.,Shi, Changzheng.,Yang, Qiong.,...&Shen, Dinggang.(2015).Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder.PSYCHIATRY RESEARCH-NEUROIMAGING,234(3),346-351.
MLA Peng, Ziwen,et al."Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder".PSYCHIATRY RESEARCH-NEUROIMAGING 234.3(2015):346-351.
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