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题名:
Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder
作者: Peng, Ziwen1,2,3; Li, Gang1; Shi, Feng1; Shi, Changzheng4; Yang, Qiong5; Chen, ChuQiao(陈楚侨)6; Shen, Dinggang1,2,7
文章类型: Article
关键词: Cortical thickness ; Obsessive-compulsive disorder ; Endophenotype ; Hemispheric asymmetry ; Siblings
刊名: PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN号: 0925-4927
出版日期: 2015-12-30
卷号: 234, 期号:3, 页码:346-351
收录类别: SCI
英文摘要: Obsessive-compulsive disorder (OCD) is considered to be associated with atypical brain asymmetry. However, no study has examined the asymmetry in OCD from the perspective of cortical morphometry. This study is aimed to describe the characteristics of cortical asymmetry in OCD patients, and to investigate whether these features exist in their unaffected siblings - a vital step in identifying putative endophenotypes for OCD. A total of 48 subjects (16 OCD patients, 16 unaffected siblings, and 16 matched controls) were recruited who had complete magnetic resonance imaging scans. Left-right hemispheric asymmetries of cortical thickness were measured using a surface-based threshold-free cluster enhancement method. OCD patients and siblings both showed leftward asymmetries of cortical thickness in the anterior cingulate cortex (ACC), which showed a significant positive correlation with compulsive subscale scores. In addition, siblings and healthy controls showed significantly decreased leftward asymmetries in the orbitofrontal cortex (OFC), and the decreased leftward bias in the OFC was accompanied by lower scales on the Yale-Brown Obsessive-Compulsive Scale. To sum up, leftward asymmetries of cortical thickness in the ACC may represent an endophenotype of increased hereditary risk for OCD, while decreased leftward asymmetries of cortical thickness in the OFC may represent a protective factor. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
语种: 英语
WOS记录号: WOS:000366011200009
DOI标识: 10.1016/j.pscychresns.2015.10.005
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Clinical Neurology ; Neuroimaging ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; HEMISPHERIC ASYMMETRIES ; ANTERIOR CINGULATE ; MATTER ABNORMALITIES ; BRAIN ; INVENTORY ; THICKNESS ; ATTENTION ; VERSION
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内容类型: 期刊论文
URI标识: http://ir.psych.ac.cn/handle/311026/15382
Appears in Collections:中国科学院心理健康重点实验室_期刊论文

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作者单位: 1.S China Normal Univ, Sch Psychol, Ctr Studies Psychol Applicat, Guangzhou, Guangdong, Peoples R China
2.Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
3.Univ N Carolina, BRIC, Chapel Hill, NC 27599 USA
4.Jinan Univ, Affiliated Hosp 1, Med Imaging Ctr, Guangzhou, Guangdong, Peoples R China
5.Guangzhou Psychiat Hosp, Guangzhou, Guangdong, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
7.Korea Univ, Dept Brain & Cognit Engn, Seoul, South Korea

Recommended Citation:
Peng, Ziwen,Li, Gang,Shi, Feng,et al. Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,234(3):346-351.
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