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Effects of repeated quetiapine treatment on conditioned avoidance responding in rats
Gao, Jun1,2,3; Feng, Min3,4; Swalve, Natashia3; Davis, Collin3; Sui, Nan4; Li, Ming3
2015-12-15
发表期刊EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
文章类型Article
卷号769期号:0页码:154-161
摘要The present study characterized the behavioral mechanisms of avoidance-disruptive effect of quetiapine in the conditioned avoidance response test under two behavioral testing (2 warning signals vs. 1 warning signal) and two drug administration conditions (subcutaneous vs. intravenous). In Experiments 1 and 2, well-trained adult male Sprague-Dawley rats were tested under the subcutaneous (s.c.) quetiapine treatment (5.0, 15.0, 25.0, 50.0 mg/kg) for 7 days in a novel procedure consisting of two conditioned stimuli (CS) (white noise serving as C51 and pure tone as C52). Only the highest dose (50.0 mg/kg) produced a persistent suppression of the avoidance response without impairing the escape response. The magnitude of suppression of the C51 avoidance was similar to that of C52 avoidance. No significant group difference was found in the quetiapine (15.0 mg/kg, s.c.) challenge test, indicating a lack of a long-term quetiapine effect. In Experiment 3, well-trained rats were tested under the intravenous (i.v.) quetiapine treatment (3.0, 9.0, 15.0 mg/kg) for 5 days and challenged with quetiapine (6.0 mg/kg, i.v. followed by 9.0 mg/kg, s.c.). Only the white noise was used as the CS. Similar to what was being observed in Experiments 1 and 2, intravenously administered quetiapine dose-dependently suppressed avoidance responding during the drug test days, but did not alter drug sensitivity in the challenge days. Thus, quetiapine does not appear to show a preferential inhibition of the avoidance response to a less salient stimulus; and prior quetiapine treatment (s.c. and iv.) does not cause a sensitization or tolerance to quetiapine. (C) 2015 Elsevier B.V. All rights reserved.
关键词Quetiapine CS1 and CS2 Conditioned avoidance response Sensitization Tolerance
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Pharmacology & Pharmacy
WOS记录号WOS:000366137800019
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]DOPAMINE-D-2 RECEPTOR OCCUPANCY ; ANTIPSYCHOTIC-DRUGS ; BEHAVIORAL MECHANISMS ; MOTIVATIONAL SALIENCE ; CLOZAPINE TOLERANCE ; ANIMAL-MODELS ; TIME-COURSE ; SCHIZOPHRENIA ; SENSITIZATION ; OLANZAPINE
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15386
专题中国科学院心理健康重点实验室
作者单位1.Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing, Peoples R China
2.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
3.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Gao, Jun,Feng, Min,Swalve, Natashia,et al. Effects of repeated quetiapine treatment on conditioned avoidance responding in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2015,769(0):154-161.
APA Gao, Jun,Feng, Min,Swalve, Natashia,Davis, Collin,Sui, Nan,&Li, Ming.(2015).Effects of repeated quetiapine treatment on conditioned avoidance responding in rats.EUROPEAN JOURNAL OF PHARMACOLOGY,769(0),154-161.
MLA Gao, Jun,et al."Effects of repeated quetiapine treatment on conditioned avoidance responding in rats".EUROPEAN JOURNAL OF PHARMACOLOGY 769.0(2015):154-161.
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