Effects of repeated quetiapine treatment on conditioned avoidance responding in rats

	Effects of repeated quetiapine treatment on conditioned avoidance responding in rats
	Gao, Jun1,2,3 ; Feng, Min3,4 ; Swalve, Natashia 3; Davis, Collin 3; Sui, Nan4 ; Li, Ming 3
摘要	The present study characterized the behavioral mechanisms of avoidance-disruptive effect of quetiapine in the conditioned avoidance response test under two behavioral testing (2 warning signals vs. 1 warning signal) and two drug administration conditions (subcutaneous vs. intravenous). In Experiments 1 and 2, well-trained adult male Sprague-Dawley rats were tested under the subcutaneous (s.c.) quetiapine treatment (5.0, 15.0, 25.0, 50.0 mg/kg) for 7 days in a novel procedure consisting of two conditioned stimuli (CS) (white noise serving as C51 and pure tone as C52). Only the highest dose (50.0 mg/kg) produced a persistent suppression of the avoidance response without impairing the escape response. The magnitude of suppression of the C51 avoidance was similar to that of C52 avoidance. No significant group difference was found in the quetiapine (15.0 mg/kg, s.c.) challenge test, indicating a lack of a long-term quetiapine effect. In Experiment 3, well-trained rats were tested under the intravenous (i.v.) quetiapine treatment (3.0, 9.0, 15.0 mg/kg) for 5 days and challenged with quetiapine (6.0 mg/kg, i.v. followed by 9.0 mg/kg, s.c.). Only the white noise was used as the CS. Similar to what was being observed in Experiments 1 and 2, intravenously administered quetiapine dose-dependently suppressed avoidance responding during the drug test days, but did not alter drug sensitivity in the challenge days. Thus, quetiapine does not appear to show a preferential inhibition of the avoidance response to a less salient stimulus; and prior quetiapine treatment (s.c. and iv.) does not cause a sensitization or tolerance to quetiapine. (C) 2015 Elsevier B.V. All rights reserved.
关键词	Quetiapine CS1 and CS2 Conditioned avoidance response Sensitization Tolerance
	2015-12-15
语种	英语
发表期刊	EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN	0014-2999
卷号	769 期号:0 页码:154-161
期刊论文类型	Article
收录类别	SCI
WOS关键词	DOPAMINE-D-2 RECEPTOR OCCUPANCY ; ANTIPSYCHOTIC-DRUGS ; BEHAVIORAL MECHANISMS ; MOTIVATIONAL SALIENCE ; CLOZAPINE TOLERANCE ; ANIMAL-MODELS ; TIME-COURSE ; SCHIZOPHRENIA ; SENSITIZATION ; OLANZAPINE
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:000366137800019
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15386
专题	中国科学院心理健康重点实验室
作者单位	1.Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing, Peoples R China 2.Southwest Univ, Fac Psychol, Chongqing, Peoples R China 3.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Gao, Jun,Feng, Min,Swalve, Natashia,et al. Effects of repeated quetiapine treatment on conditioned avoidance responding in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2015,769(0):154-161.
APA	Gao, Jun,Feng, Min,Swalve, Natashia,Davis, Collin,Sui, Nan,&Li, Ming.(2015).Effects of repeated quetiapine treatment on conditioned avoidance responding in rats.EUROPEAN JOURNAL OF PHARMACOLOGY,769(0),154-161.
MLA	Gao, Jun,et al."Effects of repeated quetiapine treatment on conditioned avoidance responding in rats".EUROPEAN JOURNAL OF PHARMACOLOGY 769.0(2015):154-161.

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