Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice

	Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice
	Wu, Beibei 1,4; Wei, Yan 1; Wang, Yujing 1,4; Su, Tao 1; Zhou, Lei 5; Liu, Ying1 ; He, Rongqiao 1,2,3
摘要	In addition to D-Glucose, D-Ribose is also abnormally elevated in the urine of type 2 diabetic patients, establishing a positive correlation between the concentration of uric D-Ribose and the severity of diabetes. Intraperitoneal injection of D-Ribose causes memory loss and brain inflammation in mice. To simulate a chronic progression of age-related cognitive impairment, we orally administered D-Ribose by gavage at both a low and high dose to 8 week-old male C57BL/6J mice daily for a total of 6 months, followed by behavioral, histological and biochemical analysis. We found that long-term oral administration of D-Ribose impairs spatial learning and memory, accompanied by anxiety-like behavior. Tau was hyperphosphorylated at AT8, S396, S214 and T181 in the brain. A beta-like deposition was also found in the hippocampus for the high dose group. D-Glucose-gavaged mice did not show significant memory loss and anxiety-like behavior under the same experimental conditions. These results demonstrate that a long-term oral administration of D-Ribose not only induces memory loss with anxiety-like behavior, but also elevates A beta-like deposition and Tau hyperphosphorylation, presenting D-Ribose-gavaged mouse as a model for agerelated cognitive impairment and diabetic encephalopathy.
关键词	D-ribose Memory Impairment Tau Hyperphosphorylation a Beta-like Deposition Anxiety-like Behavior Gerotarget
	2015-10-27
语种	英语
发表期刊	ONCOTARGET
ISSN	1949-2553
卷号	6 期号:33 页码:34128-34142
期刊论文类型	Article
收录类别	SCI
WOS关键词	AMYLOID PRECURSOR PROTEIN ; GLYCATION END-PRODUCTS ; TYPE-2 DIABETES-MELLITUS ; ALZHEIMERS-DISEASE ; COGNITIVE IMPAIRMENT ; PHOSPHORYLATED-TAU ; INBRED MICE ; INSULIN ; NEURONS ; CELLS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000366107200021
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15391
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Biophys, Ctr Expt Anim, Core Facil Prot Res, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wu, Beibei,Wei, Yan,Wang, Yujing,et al. Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice[J]. ONCOTARGET,2015,6(33):34128-34142.
APA	Wu, Beibei.,Wei, Yan.,Wang, Yujing.,Su, Tao.,Zhou, Lei.,...&He, Rongqiao.(2015).Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice.ONCOTARGET,6(33),34128-34142.
MLA	Wu, Beibei,et al."Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice".ONCOTARGET 6.33(2015):34128-34142.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Gavage of D-Ribose i（3398KB）	期刊论文	作者接受稿	暂不开放	CC BY-NC-SA	请求全文