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Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice
Wu, Beibei1,4; Wei, Yan1; Wang, Yujing1,4; Su, Tao1; Zhou, Lei5; Liu, Ying1; He, Rongqiao1,2,3
2015-10-27
Source PublicationONCOTARGET
ISSN1949-2553
SubtypeArticle
Volume6Issue:33Pages:34128-34142
AbstractIn addition to D-Glucose, D-Ribose is also abnormally elevated in the urine of type 2 diabetic patients, establishing a positive correlation between the concentration of uric D-Ribose and the severity of diabetes. Intraperitoneal injection of D-Ribose causes memory loss and brain inflammation in mice. To simulate a chronic progression of age-related cognitive impairment, we orally administered D-Ribose by gavage at both a low and high dose to 8 week-old male C57BL/6J mice daily for a total of 6 months, followed by behavioral, histological and biochemical analysis. We found that long-term oral administration of D-Ribose impairs spatial learning and memory, accompanied by anxiety-like behavior. Tau was hyperphosphorylated at AT8, S396, S214 and T181 in the brain. A beta-like deposition was also found in the hippocampus for the high dose group. D-Glucose-gavaged mice did not show significant memory loss and anxiety-like behavior under the same experimental conditions. These results demonstrate that a long-term oral administration of D-Ribose not only induces memory loss with anxiety-like behavior, but also elevates A beta-like deposition and Tau hyperphosphorylation, presenting D-Ribose-gavaged mouse as a model for agerelated cognitive impairment and diabetic encephalopathy.
KeywordD-ribose Memory Impairment Tau Hyperphosphorylation a Beta-like Deposition Anxiety-like Behavior Gerotarget
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000366107200021
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordAMYLOID PRECURSOR PROTEIN ; GLYCATION END-PRODUCTS ; TYPE-2 DIABETES-MELLITUS ; ALZHEIMERS-DISEASE ; COGNITIVE IMPAIRMENT ; PHOSPHORYLATED-TAU ; INBRED MICE ; INSULIN ; NEURONS ; CELLS
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15391
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Biophys, Ctr Expt Anim, Core Facil Prot Res, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Wu, Beibei,Wei, Yan,Wang, Yujing,et al. Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice[J]. ONCOTARGET,2015,6(33):34128-34142.
APA Wu, Beibei.,Wei, Yan.,Wang, Yujing.,Su, Tao.,Zhou, Lei.,...&He, Rongqiao.(2015).Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice.ONCOTARGET,6(33),34128-34142.
MLA Wu, Beibei,et al."Gavage of D-Ribose induces A beta-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice".ONCOTARGET 6.33(2015):34128-34142.
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