Heritability and familiality of neurological soft signs: evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives

doi:10.1017/S0033291715001580

	Heritability and familiality of neurological soft signs: evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives
	Xu, T.1 ; Wang, Y.1 ; Li, Z.1,2 ; Huang, J.1 ; Lui, S. S. Y.1,3; Tan, S. -P.4; Yu, X.5,6,7; Cheung, E. F. C.3; He, M. -G.8,9; Ott, J.10; Gur, R. E.11,12; Chan, R. C. K.1
第一作者	Xu, T. ; Wang, Y. ; Li, Z.
通讯作者邮箱	rckchan@psych.ac.cn
心理所单位排序	1
摘要	Background. Neurological soft signs (NSS) have long been considered potential endophenotypes for schizophrenia. However, few studies have investigated the heritability and familiality of NSS. The present study examined the heritability and familiality of NSS in healthy twins and patient-relative pairs. Method. The abridged version of the Cambridge Neurological Inventory was administered to 267 pairs of monozygotic twins, 124 pairs of dizygotic twins, and 75 pairs of patients with schizophrenia and their non-psychotic first-degree relatives. Results. NSS were found to have moderate but significant heritability in the healthy twin sample. Moreover, patients with schizophrenia correlated closely with their first-degree relatives on NSS. Conclusions. Taken together, the findings provide evidence on the heritability and familiality of NSS in the Han Chinese population.
关键词	Endophenotypes familiality healthy twins heritability neurological soft signs
	2016
语种	英语
DOI	10.1017/S0033291715001580
发表期刊	PSYCHOLOGICAL MEDICINE
ISSN	0033-2917
卷号	46 期号:1 页码:117-123
期刊论文类型	Article
收录类别	SCI ; SSCI ; SSCI
WOS关键词	MINOR PHYSICAL ANOMALIES ; ABNORMALITIES ; ENDOPHENOTYPES ; DISORDERS ; METAANALYSIS ; INVENTORY ; FEATURES
WOS标题词	Social Sciences ; Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Psychology ; Psychiatry
WOS类目	Psychology, Clinical ; Psychiatry ; Psychology
WOS记录号	WOS:000366651100010
Q分类	Q1
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15428
专题	中国科学院心理健康重点实验室
通讯作者	Chan, R. C. K.
作者单位	1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 4.Beijing Huilongguan Hosp, Beijing, Peoples R China 5.Peking Univ, Hosp 6, Beijing 100871, Peoples R China 6.Peking Univ Mental Hlth, Beijing, Peoples R China 7.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China 8.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510275, Guangdong, Peoples R China 9.Univ Melbourne, Ctr Eye Res Australia, Melbourne, Vic 3010, Australia 10.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Stat Genet Lab, Beijing 100101, Peoples R China 11.Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA 12.Philadelphia Vet Adm Med Ctr, Philadelphia, PA USA
推荐引用方式 GB/T 7714	Xu, T.,Wang, Y.,Li, Z.,et al. Heritability and familiality of neurological soft signs: evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives[J]. PSYCHOLOGICAL MEDICINE,2016,46(1):117-123.
APA	Xu, T..,Wang, Y..,Li, Z..,Huang, J..,Lui, S. S. Y..,...&Chan, R. C. K..(2016).Heritability and familiality of neurological soft signs: evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives.PSYCHOLOGICAL MEDICINE,46(1),117-123.
MLA	Xu, T.,et al."Heritability and familiality of neurological soft signs: evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives".PSYCHOLOGICAL MEDICINE 46.1(2016):117-123.

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