PSYCH OpenIR  > 中国科学院心理健康重点实验室
Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats
Wang, T.1; Hu, X.1; Liang, S.1; Li, W.1; Wu, X.1; Wang, L.2; Jin, F.1
2015
发表期刊BENEFICIAL MICROBES
ISSN1876-2883
文章类型Article
卷号6期号:5页码:707-717
摘要Gut microbiota play a vital role in maintaining the health of the host. Many factors affect gut microbiota; application of broad range antibiotics disturb microbiota, while probiotic application protects the microbiota. To investigate how probiotics alter the physiological and psychological changes induced by antibiotics, we tested the performance of ampicillin-treated rats in the presence or absence of Lactobacillus fermentum strain NS9, in elevated plus maze and Morris water maze. The results showed that NS9 normalised the composition of gut microbiota and alleviated the ampicillin-induced inflammation in the colon. The levels of the mineralocorticoid and N-methyl-D-aspartate receptors were also elevated in the hippocampus of the ampillicin+ NS9 treated group. NS9 administration also reduced the anxiety-like behaviour and alleviated the ampicillin-induced impairment in memory retention. These findings suggest that NS9 is beneficial to the host, because it restores the physiological and psychological abnormalities induced by ampicillin. Our results highlight how gut contents regulate the brain, and shed light on the clinical applications of probiotics to treat the side effect of antibiotics and mental disorders.
关键词Gut Microbiota Probiotic Inflammation Behaviour Hypothalamic-pituitary-adrenal Axis
DOI10.3920/BM2014.0177
收录类别SCI
语种英语
WOS研究方向Microbiology ; Nutrition & Dietetics
WOS类目Microbiology ; Nutrition & Dietetics
WOS记录号WOS:000367306800011
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]REAL-TIME PCR ; INTESTINAL MICROBIOTA ; GUT MICROBIOTA ; MATERNAL SEPARATION ; LIPID-METABOLISM ; GENE-EXPRESSION ; SPATIAL MEMORY ; BRAIN ; BEHAVIOR ; MICE
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15433
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Hangzhou Normal Univ, Inst Ageing Res, Hangzhou 311121, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714
Wang, T.,Hu, X.,Liang, S.,et al. Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats[J]. BENEFICIAL MICROBES,2015,6(5):707-717.
APA Wang, T..,Hu, X..,Liang, S..,Li, W..,Wu, X..,...&Jin, F..(2015).Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats.BENEFICIAL MICROBES,6(5),707-717.
MLA Wang, T.,et al."Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats".BENEFICIAL MICROBES 6.5(2015):707-717.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Lactobacillus fermen(488KB)期刊论文作者接受稿暂不开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, T.]的文章
[Hu, X.]的文章
[Liang, S.]的文章
百度学术
百度学术中相似的文章
[Wang, T.]的文章
[Hu, X.]的文章
[Liang, S.]的文章
必应学术
必应学术中相似的文章
[Wang, T.]的文章
[Hu, X.]的文章
[Liang, S.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。