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Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats
Wang, T.1; Hu, X.1; Liang, S.1; Li, W.1; Wu, X.1; Wang, L.2; Jin, F.1
2015
Source PublicationBENEFICIAL MICROBES
ISSN1876-2883
SubtypeArticle
Volume6Issue:5Pages:707-717
AbstractGut microbiota play a vital role in maintaining the health of the host. Many factors affect gut microbiota; application of broad range antibiotics disturb microbiota, while probiotic application protects the microbiota. To investigate how probiotics alter the physiological and psychological changes induced by antibiotics, we tested the performance of ampicillin-treated rats in the presence or absence of Lactobacillus fermentum strain NS9, in elevated plus maze and Morris water maze. The results showed that NS9 normalised the composition of gut microbiota and alleviated the ampicillin-induced inflammation in the colon. The levels of the mineralocorticoid and N-methyl-D-aspartate receptors were also elevated in the hippocampus of the ampillicin+ NS9 treated group. NS9 administration also reduced the anxiety-like behaviour and alleviated the ampicillin-induced impairment in memory retention. These findings suggest that NS9 is beneficial to the host, because it restores the physiological and psychological abnormalities induced by ampicillin. Our results highlight how gut contents regulate the brain, and shed light on the clinical applications of probiotics to treat the side effect of antibiotics and mental disorders.
KeywordGut Microbiota Probiotic Inflammation Behaviour Hypothalamic-pituitary-adrenal Axis
DOI10.3920/BM2014.0177
Indexed BySCI
Language英语
WOS Research AreaMicrobiology ; Nutrition & Dietetics
WOS SubjectMicrobiology ; Nutrition & Dietetics
WOS IDWOS:000367306800011
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordREAL-TIME PCR ; INTESTINAL MICROBIOTA ; GUT MICROBIOTA ; MATERNAL SEPARATION ; LIPID-METABOLISM ; GENE-EXPRESSION ; SPATIAL MEMORY ; BRAIN ; BEHAVIOR ; MICE
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15433
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Hangzhou Normal Univ, Inst Ageing Res, Hangzhou 311121, Zhejiang, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, T.,Hu, X.,Liang, S.,et al. Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats[J]. BENEFICIAL MICROBES,2015,6(5):707-717.
APA Wang, T..,Hu, X..,Liang, S..,Li, W..,Wu, X..,...&Jin, F..(2015).Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats.BENEFICIAL MICROBES,6(5),707-717.
MLA Wang, T.,et al."Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats".BENEFICIAL MICROBES 6.5(2015):707-717.
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