Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats

doi:10.3920/BM2014.0177

	Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats
	Wang, T.1 ; Hu, X.1 ; Liang, S.1 ; Li, W.1 ; Wu, X.1; Wang, L.2; Jin, F.1
摘要	Gut microbiota play a vital role in maintaining the health of the host. Many factors affect gut microbiota; application of broad range antibiotics disturb microbiota, while probiotic application protects the microbiota. To investigate how probiotics alter the physiological and psychological changes induced by antibiotics, we tested the performance of ampicillin-treated rats in the presence or absence of Lactobacillus fermentum strain NS9, in elevated plus maze and Morris water maze. The results showed that NS9 normalised the composition of gut microbiota and alleviated the ampicillin-induced inflammation in the colon. The levels of the mineralocorticoid and N-methyl-D-aspartate receptors were also elevated in the hippocampus of the ampillicin+ NS9 treated group. NS9 administration also reduced the anxiety-like behaviour and alleviated the ampicillin-induced impairment in memory retention. These findings suggest that NS9 is beneficial to the host, because it restores the physiological and psychological abnormalities induced by ampicillin. Our results highlight how gut contents regulate the brain, and shed light on the clinical applications of probiotics to treat the side effect of antibiotics and mental disorders.
关键词	Gut Microbiota Probiotic Inflammation Behaviour Hypothalamic-pituitary-adrenal Axis
	2015
语种	英语
DOI	10.3920/BM2014.0177
发表期刊	BENEFICIAL MICROBES
ISSN	1876-2883
卷号	6 期号:5 页码:707-717
期刊论文类型	Article
收录类别	SCI
WOS关键词	REAL-TIME PCR ; INTESTINAL MICROBIOTA ; GUT MICROBIOTA ; MATERNAL SEPARATION ; LIPID-METABOLISM ; GENE-EXPRESSION ; SPATIAL MEMORY ; BRAIN ; BEHAVIOR ; MICE
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Microbiology ; Nutrition & Dietetics
WOS类目	Microbiology ; Nutrition & Dietetics
WOS记录号	WOS:000367306800011
引用统计	被引频次：154[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15433
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Hangzhou Normal Univ, Inst Ageing Res, Hangzhou 311121, Zhejiang, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Wang, T.,Hu, X.,Liang, S.,et al. Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats[J]. BENEFICIAL MICROBES,2015,6(5):707-717.
APA	Wang, T..,Hu, X..,Liang, S..,Li, W..,Wu, X..,...&Jin, F..(2015).Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats.BENEFICIAL MICROBES,6(5),707-717.
MLA	Wang, T.,et al."Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats".BENEFICIAL MICROBES 6.5(2015):707-717.

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