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Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese
Fang, Kechi; Zhang, Kunlin; Wang, Jing
2015-12-21
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
SubtypeArticle
Volume5
AbstractPrimary Sjogren's syndrome (pSS) is a complex autoimmune disorder. So far, genetic research in pSS has lagged far behind and the underlying biological mechanism is unclear. Further exploring existing genome-wide association study (GWAS) data is urgently expected to uncover disease-related gene combination patterns. Herein, we conducted a network-based analysis by integrating pSS GWAS in Han Chinese with a protein-protein interactions network to identify pSS candidate genes. After module detection and evaluation, 8 dense modules covering 40 genes were obtained for further functional annotation. Additional 31 MHC genes with significant gene-level P-values (sigMHC-gene) were also remained. The combined module genes and sigMHC-genes, a total of 71 genes, were denoted as pSS candidate genes. Of these pSS candidates, 14 genes had been reported to be associated with any of pSS, RA, and SLE, including STAT4, GTF2I, HLA-DPB1, HLA-DRB1, PTTG1, HLA-DQB1, MBL2, TAP2, CFLAR, NFKBIE, HLA-DRA, APOM, HLA-DQA2 and NOTCH4. This is the first report of the network-assisted analysis for pSS GWAS data to explore combined gene patterns associated with pSS. Our study suggests that network-assisted analysis is a useful approach to gaining further insights into the biology of associated genes and providing important clues for future research into pSS etiology.
DOI10.1038/srep18855
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000367076000001
WOS HeadingsScience & Technology
WOS KeywordGENOME-WIDE ASSOCIATION ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; PROTEIN-INTERACTION NETWORKS ; RHEUMATOID-ARTHRITIS ; KAPPA-B ; IDENTIFIES 9 ; CLASS-II ; GENE ; SUSCEPTIBILITY ; LOCI
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15437
Collection中国科学院心理健康重点实验室
AffiliationChinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Fang, Kechi,Zhang, Kunlin,Wang, Jing. Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese[J]. SCIENTIFIC REPORTS,2015,5.
APA Fang, Kechi,Zhang, Kunlin,&Wang, Jing.(2015).Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese.SCIENTIFIC REPORTS,5.
MLA Fang, Kechi,et al."Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese".SCIENTIFIC REPORTS 5(2015).
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