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Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese
Fang, Kechi; Zhang, Kunlin; Wang, Jing
2015-12-21
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
文章类型Article
卷号5
摘要Primary Sjogren's syndrome (pSS) is a complex autoimmune disorder. So far, genetic research in pSS has lagged far behind and the underlying biological mechanism is unclear. Further exploring existing genome-wide association study (GWAS) data is urgently expected to uncover disease-related gene combination patterns. Herein, we conducted a network-based analysis by integrating pSS GWAS in Han Chinese with a protein-protein interactions network to identify pSS candidate genes. After module detection and evaluation, 8 dense modules covering 40 genes were obtained for further functional annotation. Additional 31 MHC genes with significant gene-level P-values (sigMHC-gene) were also remained. The combined module genes and sigMHC-genes, a total of 71 genes, were denoted as pSS candidate genes. Of these pSS candidates, 14 genes had been reported to be associated with any of pSS, RA, and SLE, including STAT4, GTF2I, HLA-DPB1, HLA-DRB1, PTTG1, HLA-DQB1, MBL2, TAP2, CFLAR, NFKBIE, HLA-DRA, APOM, HLA-DQA2 and NOTCH4. This is the first report of the network-assisted analysis for pSS GWAS data to explore combined gene patterns associated with pSS. Our study suggests that network-assisted analysis is a useful approach to gaining further insights into the biology of associated genes and providing important clues for future research into pSS etiology.
DOI10.1038/srep18855
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000367076000001
WOS标题词Science & Technology
关键词[WOS]GENOME-WIDE ASSOCIATION ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; PROTEIN-INTERACTION NETWORKS ; RHEUMATOID-ARTHRITIS ; KAPPA-B ; IDENTIFIES 9 ; CLASS-II ; GENE ; SUSCEPTIBILITY ; LOCI
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15437
专题中国科学院心理健康重点实验室
作者单位Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Fang, Kechi,Zhang, Kunlin,Wang, Jing. Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese[J]. SCIENTIFIC REPORTS,2015,5.
APA Fang, Kechi,Zhang, Kunlin,&Wang, Jing.(2015).Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese.SCIENTIFIC REPORTS,5.
MLA Fang, Kechi,et al."Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese".SCIENTIFIC REPORTS 5(2015).
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