Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese

doi:10.1038/srep18855

	Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese
	Fang, Kechi; Zhang, Kunlin; Wang, Jing
摘要	Primary Sjogren's syndrome (pSS) is a complex autoimmune disorder. So far, genetic research in pSS has lagged far behind and the underlying biological mechanism is unclear. Further exploring existing genome-wide association study (GWAS) data is urgently expected to uncover disease-related gene combination patterns. Herein, we conducted a network-based analysis by integrating pSS GWAS in Han Chinese with a protein-protein interactions network to identify pSS candidate genes. After module detection and evaluation, 8 dense modules covering 40 genes were obtained for further functional annotation. Additional 31 MHC genes with significant gene-level P-values (sigMHC-gene) were also remained. The combined module genes and sigMHC-genes, a total of 71 genes, were denoted as pSS candidate genes. Of these pSS candidates, 14 genes had been reported to be associated with any of pSS, RA, and SLE, including STAT4, GTF2I, HLA-DPB1, HLA-DRB1, PTTG1, HLA-DQB1, MBL2, TAP2, CFLAR, NFKBIE, HLA-DRA, APOM, HLA-DQA2 and NOTCH4. This is the first report of the network-assisted analysis for pSS GWAS data to explore combined gene patterns associated with pSS. Our study suggests that network-assisted analysis is a useful approach to gaining further insights into the biology of associated genes and providing important clues for future research into pSS etiology.
	2015-12-21
语种	英语
DOI	10.1038/srep18855
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	5
期刊论文类型	Article
收录类别	SCI
WOS关键词	GENOME-WIDE ASSOCIATION ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; PROTEIN-INTERACTION NETWORKS ; RHEUMATOID-ARTHRITIS ; KAPPA-B ; IDENTIFIES 9 ; CLASS-II ; GENE ; SUSCEPTIBILITY ; LOCI
WOS标题词	Science & Technology
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000367076000001
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/15437
专题	中国科学院心理健康重点实验室
作者单位	Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Fang, Kechi,Zhang, Kunlin,Wang, Jing. Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese[J]. SCIENTIFIC REPORTS,2015,5.
APA	Fang, Kechi,Zhang, Kunlin,&Wang, Jing.(2015).Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese.SCIENTIFIC REPORTS,5.
MLA	Fang, Kechi,et al."Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese".SCIENTIFIC REPORTS 5(2015).

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