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Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors
Zhang, Xiaoyu1,2; Zhang, Jianxin1; Wang, Li1; Li, Rui1; Zhang, Wencai1
2016-02-04
发表期刊PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
文章类型Article
卷号65期号:0页码:208-214
摘要Posttraumatic stress disorder (PTSD) is linked to abnormal amygdala activities. This study measured amygdala functional connectivity using DSM-5 criteria. There were 33 participants in the PTSD group and 33 participants in a trauma-exposed control (TEC) group, who did not have PTSD according to the PTSD checklist of the DSM-5 (PCL-5). Our findings are as follows: (1) In the PTSD group, the amygdala had increased positive connectivity with the medial prefrontal cortex (mPFC) and hippocampus, and decreased positive connectivity with the inferior mPFC and insula. The amygdala had increased negative connectivity with the orbital prefrontal cortex and decreased negative connectivity with the insula in comparison with TEC group. (2) PCL of all participants was correlated with the connectivity between the amygdala and the mPFC, hippocampus, and insula. These regions overlapped with those identified in the between-group comparisons. However, there was no association between PCL of the PTSD group and connectivity in these regions. Abnormal functional connectivity between the amygdala and mPFC subdivisions, hippocampus, and insula reveals their importance in PTSD pathogenesis. (C) 2015 Elsevier Inc. All rights reserved.
关键词PTSD DSM-5 Resting-state functional connectivity Amygdala Medial prefrontal cortex
DOI10.1016/j.pnpbp.2015.10.003
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000366709200024
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]POSTTRAUMATIC-STRESS-DISORDER ; PREFRONTAL CORTEX ; NEUROCIRCUITRY MODELS ; FMRI ; FLUCTUATIONS ; TOMOGRAPHY ; COGNITION ; SYMPTOMS ; INSIGHTS ; EMOTION
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15441
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.UCAS, Beijing 101408, Peoples R China
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Zhang, Xiaoyu,Zhang, Jianxin,Wang, Li,et al. Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2016,65(0):208-214.
APA Zhang, Xiaoyu,Zhang, Jianxin,Wang, Li,Li, Rui,&Zhang, Wencai.(2016).Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,65(0),208-214.
MLA Zhang, Xiaoyu,et al."Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 65.0(2016):208-214.
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