中国科学院心理研究所机构知识库

目的　应用与Stroop字色干扰测验相似的Simon任务和事件相关设计fMRI技术 ,探讨高血压对注意功能的影响及其相关的神经生物学基础。方法　采用Siemens公司Sonata 1 5T磁共振成像系统 ,对 12位无神经体征 ,年龄在 5 0～ 6 5岁的中老年原发高血压患者 [血压≥ 14 0

To study the characteristic brain activation involved in attention in hypertension patients by performing the Simon task which is similar to stroop task , and by using eventrelated functional MRI (fMRI) . Methods: The study sample consisted of 2 groups : 12 stroke2 and dementia2free hypertension patients aged 50 to 65 years , and 12 matched healthy old subjects. fMRI wasscanned on a Sonata 1. 5 T scanner (Siemens) while they were performing attention tasks. The t-test was used to analyze the behavioral data between the two groups. Image data were motion corrected and spatially normalized according to the standard coordinates, and spatially smoothed with isotopic Guassian Kernel.Activation maps for attention conditions were generated respectively by deconvolve analysis. The general linear test was used to compare the cortex activation pattern and different active areas between tasks and groups. Results: There were no significant differences between hypertension patients [ (547 ±271) ms ,(78 ±25) %] and control group [ (529 ±321) ms , (89 ±8) %] in reaction times and accuracy when performing attention tasks ( t = 0. 870 , P = 0. 865 ; t = - 1. 597 , P = 0. 121) . But the standard error of mean of the patient′s accuracy rate (6. 51) was significantly higher than that of the control group (2. 22) .Functional imaging data showed significantly greater activation in the patients compared with control group while performing the same task , especially in the prefrontal cortex (BA 6 , 9 , and 10) . Conclusion: fMRI appears to be more sensitive than neurological and neuropsychological evaluations in early hypertension associated cognitive impairments.