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Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia
Jiang, L.1,2; Xu, Y.3; Zhu, X-T1,2,4; Yang, Z.1,2; Li, H-J1,2; Zuo, X-N1,2,5
2015-05-12
发表期刊TRANSLATIONAL PSYCHIATRY
ISSN2158-3188
文章类型Article
卷号5期号:5页码:e566
摘要Schizophrenia is increasingly thought of as a brain network or connectome disorder and is associated with neurodevelopmental processes. Previous studies have suggested the important role of anatomical distance in developing a connectome with optimized performance regarding both the cost and efficiency of information processing. Distance-related disturbances during development have not been investigated in schizophrenia. To test the distance-related miswiring profiles of connectomes in schizophrenia, we acquired resting-state images from 20 adulthood-onset (AOS) and 26 early-onset schizophrenia (EOS) patients, as well as age-matched healthy controls. All patients were drug naive and had experienced their first psychotic episode. A novel threshold-free surface-based analytic framework was developed to examine local-to-remote functional connectivity profiles in both AOS and EOS patients. We observed consistent increases of local connectivity across both EOS and AOS patients in the right superior frontal gyrus, where the connectivity strength was correlated with a positive syndrome score in AOS patients. In contrast, EOS but not AOS patients exhibited reduced local connectivity within the right postcentral gyrus and the left middle occipital cortex. These regions' remote connectivity with their interhemispheric areas and brain network hubs was altered. Diagnosis-age interactions were detectable for both local and remote connectivity profiles. The functional covariance between local and remote homotopic connectivity was present in typically developing controls, but was absent in EOS patients. These findings suggest that a distance-dependent miswiring pattern may be one of the key neurodevelopmental features of the abnormal connectome organization in schizophrenia.
DOI10.1038/tp.2015.59
收录类别SCI ; SSCI
语种英语
项目资助者National Key Basic Research and Development (973) Program(2015CB351702) ; National Natural Science Foundation(81220108014) ; Startup Foundation for Young Talents of the Institute of Psychology(Y1CX222005) ; Hundred Talents Program and the Key Research Program of the Chinese Academy of Sciences(KSZD-EW-TZ-002) ; Program for New Century Excellent Talents (NCET) in University ; Natural Science Foundation of China(11204369 ; 81171409 ; 81471740)
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000367657200003
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]RESTING-STATE FMRI ; BRAIN FUNCTIONAL NETWORKS ; REGIONAL HOMOGENEITY ; CHILDHOOD-ONSET ; 1ST-EPISODE SCHIZOPHRENIA ; WHITE-MATTER ; LIFE-SPAN ; INTERHEMISPHERIC COORDINATION ; PARANOID SCHIZOPHRENIA ; 1ST-DEGREE RELATIVES
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19449
专题中国科学院行为科学重点实验室
作者单位1.Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Southwest Univ, Fac Psychol, Beibei, Peoples R China
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Jiang, L.,Xu, Y.,Zhu, X-T,et al. Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2015,5(5):e566.
APA Jiang, L.,Xu, Y.,Zhu, X-T,Yang, Z.,Li, H-J,&Zuo, X-N.(2015).Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia.TRANSLATIONAL PSYCHIATRY,5(5),e566.
MLA Jiang, L.,et al."Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia".TRANSLATIONAL PSYCHIATRY 5.5(2015):e566.
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