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Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia
Jiang, L.1,2; Xu, Y.3; Zhu, X-T1,2,4; Yang, Z.1,2; Li, H-J1,2; Zuo, X-N1,2,5
2015-05-12
Source PublicationTRANSLATIONAL PSYCHIATRY
ISSN2158-3188
SubtypeArticle
Volume5Issue:5Pages:e566
AbstractSchizophrenia is increasingly thought of as a brain network or connectome disorder and is associated with neurodevelopmental processes. Previous studies have suggested the important role of anatomical distance in developing a connectome with optimized performance regarding both the cost and efficiency of information processing. Distance-related disturbances during development have not been investigated in schizophrenia. To test the distance-related miswiring profiles of connectomes in schizophrenia, we acquired resting-state images from 20 adulthood-onset (AOS) and 26 early-onset schizophrenia (EOS) patients, as well as age-matched healthy controls. All patients were drug naive and had experienced their first psychotic episode. A novel threshold-free surface-based analytic framework was developed to examine local-to-remote functional connectivity profiles in both AOS and EOS patients. We observed consistent increases of local connectivity across both EOS and AOS patients in the right superior frontal gyrus, where the connectivity strength was correlated with a positive syndrome score in AOS patients. In contrast, EOS but not AOS patients exhibited reduced local connectivity within the right postcentral gyrus and the left middle occipital cortex. These regions' remote connectivity with their interhemispheric areas and brain network hubs was altered. Diagnosis-age interactions were detectable for both local and remote connectivity profiles. The functional covariance between local and remote homotopic connectivity was present in typically developing controls, but was absent in EOS patients. These findings suggest that a distance-dependent miswiring pattern may be one of the key neurodevelopmental features of the abnormal connectome organization in schizophrenia.
DOI10.1038/tp.2015.59
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Key Basic Research and Development (973) Program(2015CB351702) ; National Natural Science Foundation(81220108014) ; Startup Foundation for Young Talents of the Institute of Psychology(Y1CX222005) ; Hundred Talents Program and the Key Research Program of the Chinese Academy of Sciences(KSZD-EW-TZ-002) ; Program for New Century Excellent Talents (NCET) in University ; Natural Science Foundation of China(11204369 ; 81171409 ; 81471740)
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000367657200003
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordRESTING-STATE FMRI ; BRAIN FUNCTIONAL NETWORKS ; REGIONAL HOMOGENEITY ; CHILDHOOD-ONSET ; 1ST-EPISODE SCHIZOPHRENIA ; WHITE-MATTER ; LIFE-SPAN ; INTERHEMISPHERIC COORDINATION ; PARANOID SCHIZOPHRENIA ; 1ST-DEGREE RELATIVES
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Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19449
Collection中国科学院行为科学重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Southwest Univ, Fac Psychol, Beibei, Peoples R China
Recommended Citation
GB/T 7714
Jiang, L.,Xu, Y.,Zhu, X-T,et al. Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2015,5(5):e566.
APA Jiang, L.,Xu, Y.,Zhu, X-T,Yang, Z.,Li, H-J,&Zuo, X-N.(2015).Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia.TRANSLATIONAL PSYCHIATRY,5(5),e566.
MLA Jiang, L.,et al."Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia".TRANSLATIONAL PSYCHIATRY 5.5(2015):e566.
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