Institutional Repository of Key Laboratory of Behavioral Science, CAS
Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia | |
Jiang, L.1,2; Xu, Y.3; Zhu, X-T1,2,4; Yang, Z.1,2; Li, H-J1,2; Zuo, X-N1,2,5 | |
心理所单位排序 | 1 |
摘要 | Schizophrenia is increasingly thought of as a brain network or connectome disorder and is associated with neurodevelopmental processes. Previous studies have suggested the important role of anatomical distance in developing a connectome with optimized performance regarding both the cost and efficiency of information processing. Distance-related disturbances during development have not been investigated in schizophrenia. To test the distance-related miswiring profiles of connectomes in schizophrenia, we acquired resting-state images from 20 adulthood-onset (AOS) and 26 early-onset schizophrenia (EOS) patients, as well as age-matched healthy controls. All patients were drug naive and had experienced their first psychotic episode. A novel threshold-free surface-based analytic framework was developed to examine local-to-remote functional connectivity profiles in both AOS and EOS patients. We observed consistent increases of local connectivity across both EOS and AOS patients in the right superior frontal gyrus, where the connectivity strength was correlated with a positive syndrome score in AOS patients. In contrast, EOS but not AOS patients exhibited reduced local connectivity within the right postcentral gyrus and the left middle occipital cortex. These regions' remote connectivity with their interhemispheric areas and brain network hubs was altered. Diagnosis-age interactions were detectable for both local and remote connectivity profiles. The functional covariance between local and remote homotopic connectivity was present in typically developing controls, but was absent in EOS patients. These findings suggest that a distance-dependent miswiring pattern may be one of the key neurodevelopmental features of the abnormal connectome organization in schizophrenia. |
2015-05-12 | |
语种 | 英语 |
DOI | 10.1038/tp.2015.59 |
发表期刊 | TRANSLATIONAL PSYCHIATRY |
ISSN | 2158-3188 |
卷号 | 5期号:5页码:e566 |
期刊论文类型 | Article |
收录类别 | SCI ; SSCI ; SSCI |
WOS关键词 | RESTING-STATE FMRI ; BRAIN FUNCTIONAL NETWORKS ; REGIONAL HOMOGENEITY ; CHILDHOOD-ONSET ; 1ST-EPISODE SCHIZOPHRENIA ; WHITE-MATTER ; LIFE-SPAN ; INTERHEMISPHERIC COORDINATION ; PARANOID SCHIZOPHRENIA ; 1ST-DEGREE RELATIVES |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000367657200003 |
资助机构 | National Key Basic Research and Development (973) Program(2015CB351702) ; National Natural Science Foundation(81220108014) ; Startup Foundation for Young Talents of the Institute of Psychology(Y1CX222005) ; Program for New Century Excellent Talents (NCET) in University ; Natural Science Foundation of China(11204369 ; 81171409 ; 81471740) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/19449 |
专题 | 中国科学院行为科学重点实验室 认知与发展心理学研究室 健康与遗传心理学研究室 |
通讯作者 | Zuo, X-N |
作者单位 | 1.Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 3.Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Southwest Univ, Fac Psychol, Beibei, Peoples R China |
第一作者单位 | 中国科学院行为科学重点实验室; 管理支撑系统 |
通讯作者单位 | 中国科学院行为科学重点实验室; 管理支撑系统 |
推荐引用方式 GB/T 7714 | Jiang, L.,Xu, Y.,Zhu, X-T,et al. Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2015,5(5):e566. |
APA | Jiang, L.,Xu, Y.,Zhu, X-T,Yang, Z.,Li, H-J,&Zuo, X-N.(2015).Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia.TRANSLATIONAL PSYCHIATRY,5(5),e566. |
MLA | Jiang, L.,et al."Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia".TRANSLATIONAL PSYCHIATRY 5.5(2015):e566. |
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