Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi

doi:10.1038/tp.2015.32

PSYCH OpenIR > 健康与遗传心理学研究室

	Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi
	Nemoda, Z.1,2; Massart, R.1,2; Suderman, M.1,2,3; Hallett, M.3; Li, T.4; Coote, M.4; Cody, N.1; Sun, Z. S.5; Soares, C. N.4,6,7; Turecki, G.8; Steiner, M.4,6,7; Szyf, M.1,2,3
摘要	Depression affects 10-15% of pregnant women and has been associated with preterm delivery and later developmental, behavioural and learning disabilities. We tested the hypothesis that maternal depression is associated with DNA methylation alterations in maternal T lymphocytes, neonatal cord blood T lymphocytes and adult offspring hippocampi. Genome-wide DNA methylation of CD3+ T lymphocytes isolated from 38 antepartum maternal and 44 neonatal cord blood samples were analyzed using Illumina Methylation 450 K microarrays. Previously obtained methylation data sets using methylated DNA immunoprecipitation and array-hybridization of 62 postmortem hippocampal samples of adult males were re-analyzed to test associations with history of maternal depression. We found 145 (false discovery rate (FDR) q < 0.05) and 2520 (FDR q < 0.1) differentially methylated CG-sites in cord blood T lymphocytes of neonates from the maternal depression group as compared with the control group. However, no significant DNA methylation differences were detected in the antepartum maternal T lymphocytes of our preliminary data set. We also detected 294 differentially methylated probes (FDR q < 0.1) in hippocampal samples associated with history of maternal depression. We observed a significant overlap (P = 0.002) of 33 genes with changes in DNA methylation in T lymphocytes of neonates and brains of adult offspring. Many of these genes are involved in immune system functions. Our results show that DNA methylation changes in offspring associated with maternal depression are detectable at birth in the immune system and persist to adulthood in the brain. This is consistent with the hypothesis that system-wide epigenetic changes are involved in life-long responses to maternal depression in the offspring.
	2015-04-07
语种	英语
DOI	10.1038/tp.2015.32
发表期刊	TRANSLATIONAL PSYCHIATRY
ISSN	2158-3188
卷号	5 期号:0 页码:e545
期刊论文类型	Article
收录类别	SCI
WOS关键词	INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW ; RECEPTOR GENE NR3C1 ; GLUCOCORTICOID-RECEPTOR ; EPIGENETIC REGULATION ; POSTNATAL DEPRESSION ; REGULATORY ELEMENTS ; DSM-IV ; PREGNANCY ; SCALE ; LIFE
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000367655200005
资助机构	Canadian Institutes of Health Research (CIHR)(CCM-104889) ; Marie Curie International Outgoing Fellowship within the Seventh European Community Framework Programme(276107)
引用统计	被引频次：88[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19450
专题	健康与遗传心理学研究室
作者单位	1.McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3G 1Y6, Canada 2.McGill Univ, Sackler Program Epigenet & Psychobiol, Montreal, PQ, Canada 3.McGill Univ, McGill Ctr Bioinformat, Montreal, PQ, Canada 4.St Josephs Healthcare, Womens Hlth Concerns Clin, Hamilton, ON, Canada 5.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China 6.McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON L8P 3B6, Canada 7.McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON L8P 3B6, Canada 8.Douglas Mental Hlth Univ Inst, McGill Grp Suicide Studies, Montreal, PQ, Canada
推荐引用方式 GB/T 7714	Nemoda, Z.,Massart, R.,Suderman, M.,et al. Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi[J]. TRANSLATIONAL PSYCHIATRY,2015,5(0):e545.
APA	Nemoda, Z..,Massart, R..,Suderman, M..,Hallett, M..,Li, T..,...&Szyf, M..(2015).Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi.TRANSLATIONAL PSYCHIATRY,5(0),e545.
MLA	Nemoda, Z.,et al."Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi".TRANSLATIONAL PSYCHIATRY 5.0(2015):e545.

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