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Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi
Nemoda, Z.1,2; Massart, R.1,2; Suderman, M.1,2,3; Hallett, M.3; Li, T.4; Coote, M.4; Cody, N.1; Sun, Z. S.5; Soares, C. N.4,6,7; Turecki, G.8; Steiner, M.4,6,7; Szyf, M.1,2,3
2015-04-07
Source PublicationTRANSLATIONAL PSYCHIATRY
ISSN2158-3188
SubtypeArticle
Volume5Issue:0Pages:e545
AbstractDepression affects 10-15% of pregnant women and has been associated with preterm delivery and later developmental, behavioural and learning disabilities. We tested the hypothesis that maternal depression is associated with DNA methylation alterations in maternal T lymphocytes, neonatal cord blood T lymphocytes and adult offspring hippocampi. Genome-wide DNA methylation of CD3+ T lymphocytes isolated from 38 antepartum maternal and 44 neonatal cord blood samples were analyzed using Illumina Methylation 450 K microarrays. Previously obtained methylation data sets using methylated DNA immunoprecipitation and array-hybridization of 62 postmortem hippocampal samples of adult males were re-analyzed to test associations with history of maternal depression. We found 145 (false discovery rate (FDR) q < 0.05) and 2520 (FDR q < 0.1) differentially methylated CG-sites in cord blood T lymphocytes of neonates from the maternal depression group as compared with the control group. However, no significant DNA methylation differences were detected in the antepartum maternal T lymphocytes of our preliminary data set. We also detected 294 differentially methylated probes (FDR q < 0.1) in hippocampal samples associated with history of maternal depression. We observed a significant overlap (P = 0.002) of 33 genes with changes in DNA methylation in T lymphocytes of neonates and brains of adult offspring. Many of these genes are involved in immune system functions. Our results show that DNA methylation changes in offspring associated with maternal depression are detectable at birth in the immune system and persist to adulthood in the brain. This is consistent with the hypothesis that system-wide epigenetic changes are involved in life-long responses to maternal depression in the offspring.
DOI10.1038/tp.2015.32
Indexed BySCI
Language英语
Funding OrganizationCanadian Institutes of Health Research (CIHR)(CCM-104889) ; Marie Curie International Outgoing Fellowship within the Seventh European Community Framework Programme(276107)
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000367655200005
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordINTERNATIONAL NEUROPSYCHIATRIC INTERVIEW ; RECEPTOR GENE NR3C1 ; GLUCOCORTICOID-RECEPTOR ; EPIGENETIC REGULATION ; POSTNATAL DEPRESSION ; REGULATORY ELEMENTS ; DSM-IV ; PREGNANCY ; SCALE ; LIFE
Citation statistics
Cited Times:44[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19450
Collection健康与遗传心理学研究室
Affiliation1.McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3G 1Y6, Canada
2.McGill Univ, Sackler Program Epigenet & Psychobiol, Montreal, PQ, Canada
3.McGill Univ, McGill Ctr Bioinformat, Montreal, PQ, Canada
4.St Josephs Healthcare, Womens Hlth Concerns Clin, Hamilton, ON, Canada
5.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China
6.McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON L8P 3B6, Canada
7.McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON L8P 3B6, Canada
8.Douglas Mental Hlth Univ Inst, McGill Grp Suicide Studies, Montreal, PQ, Canada
Recommended Citation
GB/T 7714
Nemoda, Z.,Massart, R.,Suderman, M.,et al. Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi[J]. TRANSLATIONAL PSYCHIATRY,2015,5(0):e545.
APA Nemoda, Z..,Massart, R..,Suderman, M..,Hallett, M..,Li, T..,...&Szyf, M..(2015).Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi.TRANSLATIONAL PSYCHIATRY,5(0),e545.
MLA Nemoda, Z.,et al."Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi".TRANSLATIONAL PSYCHIATRY 5.0(2015):e545.
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