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特质焦虑个体警觉网络的静息态与任务态 脑成像研究
Alternative TitleSalience network in trait anxiety: evidencesfrom resting-state and task-state fMRI
Thesis Advisor李雪冰
Degree Grantor中国科学院研究生院
Place of Conferral北京
Degree Discipline心理学
Keyword特质焦虑 警觉网络 静息态 任务态 脑成像
Other AbstractIn recent years, a growing number of studies have used functional MRI methods to explore the neurocognitive mechanism of anxiety from the perspective of brain networks. Those imaging studies reported several abnormal resting-state networks, including the central executive network, the ventral attention network, the salience network and emotionalprocessing network, all of which play important rolesin anxiety. However, few studies have examinedthe role of the salience network in anxiety. The salience network is important in salience processing and executive control, which areinvolved in the generation and maintenance of anxiety symptoms. Furthermore, the regions anchored in this network such as amygdala, anterior insula and dorsal anterior cingulatedcortex are involved in the emotional feeling, salience processing and response inhibition.However, no studies have examinedthe inter-network and intra-network functional connectionof the salience network. Furthermore, alteration of anticipation of uncertainty is regarded as a core feature of anxiety disorders, several abnormalcognitive processes including inflated estimationof threat cost and probability, hypervigilance, heightened reactivity to threat, behavioral and cognitiveavoidance, which are all involved in the anticipationof uncertainty. The brain regions which anchoredin the SN(e.g.amygdala, insula and dACC) and prefrontal cortex activatedin those processes. However, no direct study has explored the role of anticipation in trait anxiety and what neural circuits play roles in the interactionbetween anxiety and anticipation.
In the present thesis, two studies were used to explore the interesting issues mentioned before. In the study one, the resting-state functional connectivity wasused one, we found that no difference of FCin the salience network between the two groups, however, the high anxious group showsthe distributed increased FCbetween the SNand other brain systems such as the executive control network, the default mode network. In the study two, ROI analysis found that amygdalaand dACC show greater activation during the uncertainty condition compared the certaintyone. In whole brain analysis, we found the interactioneffect on inferiorfrontal gyrus,dorsal medialprefrontalcortex and medial temporal gyrus. Those results suggest that duringresting-state, the high anxious group hadabnormal FCbetween the SN and the distributed networks, which play important roles in salience processing and cognitive control. In the uncertainty situation, the high anxious participants show greater activationsin those regions, which may indicate that the high anxious participants usedmore cognitive effort to process uncertainty.
Subject Area基础心理学
Document Type学位论文
Recommended Citation
GB/T 7714
耿海洋. 特质焦虑个体警觉网络的静息态与任务态 脑成像研究[D]. 北京. 中国科学院研究生院,2015.
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