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The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder
Jin, J.1,2,3; Liu, L.1,2,3; Gao, Q.1,2,3; Chan, R. C. K.4; Li, H.1,2,3; Chen, Y.1,2,3; Wang, Y.1,2,3; Qian, Q.1,2,3
2016-02-01
Source PublicationGENES BRAIN AND BEHAVIOR
ISSN1601-1848
SubtypeArticle
Volume15Issue:2Pages:271-279
AbstractChildren with attention-deficit/hyperactivity disorder (ADHD) usually display deficits in executive function (EF), which are primarily mediated by prefrontal cortex (PFC). The functional polymorphism of catechol-O-methyltransferase (COMT), Val158Met (rs4680), leads to observed polymorphic differences in the degradation of dopamine within PFC. This study aimed to explore the effect of rs4680 on EF using case-control design. In addition, considering the dynamic development of EF, we also attempted to investigate whether this genetic influence changes during development or not. A total of 597 ADHD children and 154 unaffected controls were recruited. The EF was evaluated using Rey-Osterrieth complex figure test (RCFT), trail making test (TMT) and Stroop color and word test for working memory, shifting and inhibition. Association between genotype and EF was analyzed using analysis of covariance (ancova). The results showed significant interaction effect of genotype and ADHD diagnosis on RCFT performance (P<0.001). However, the associated genotypes between ADHD and controls were divergent. In ADHD, the Met carriers performed better than the Val homozygotes on detail immediate [(10.38 +/- 6.90) vs. (9.33 +/- 6.92), P=0.007] and detail delay [(9.96 +/- 6.86) vs. (8.86 +/- 6.89), P=0.004], while Val homozygotes showed better performance compared with Met carrier controls [for detail immediate (14.55 +/- 6.18) vs. (11.10 +/- 6.45), P<0.001; for detail delay (14.31 +/- 5.96) vs. (11.31 +/- 6.96), P=0.001]. We did not find significant interaction between genetic variant and development. COMTVal158Met (rs4680) may have divergent effect on working memory in ADHD children compared with healthy controls.
KeywordADHD COMT development executive function Val158Met
DOI10.1111/gbb.12270
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Development Program of China(2014CB846104) ; National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2015BAI13B01) ; National Natural Sciences Foundation of China(81571340 ; Program for New Century Excellent Talents in University(NCET-11-0013) ; 81301171)
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000369768400006
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordCATECHOL-O-METHYLTRANSFERASE ; DEFICIT HYPERACTIVITY DISORDER ; 22Q11.2 DELETION SYNDROME ; CARDIO-FACIAL SYNDROME ; COGNITIVE FUNCTION ; WORKING-MEMORY ; VAL(158)MET POLYMORPHISM ; PREFRONTAL CORTEX ; NUCLEUS-ACCUMBENS ; GENOTYPE
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Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19566
Collection中国科学院心理健康重点实验室
Affiliation1.Peking Univ, Hosp 6, Inst Mental Hlth, 51 Hua Yuan Bei Lu, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, 51 Hua Yuan Bei Lu, Beijing 100191, Peoples R China
3.Peking Univ, Key Lab Mental Hlth, Minist Hlth, 51 Hua Yuan Bei Lu, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
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Jin, J.,Liu, L.,Gao, Q.,et al. The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder[J]. GENES BRAIN AND BEHAVIOR,2016,15(2):271-279.
APA Jin, J..,Liu, L..,Gao, Q..,Chan, R. C. K..,Li, H..,...&Qian, Q..(2016).The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder.GENES BRAIN AND BEHAVIOR,15(2),271-279.
MLA Jin, J.,et al."The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder".GENES BRAIN AND BEHAVIOR 15.2(2016):271-279.
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