PSYCH OpenIR  > 中国科学院行为科学重点实验室
Lifespan anxiety is reflected in human amygdala cortical connectivity
He, Ye1,2,3,4; Xu, Ting1,2,3; Zhang, Wei5; Zuo, Xi-Nian1,2,3,6,7
2016-03-01
Source PublicationHUMAN BRAIN MAPPING
ISSN1065-9471
SubtypeArticle
Volume37Issue:3Pages:1178-1193
AbstractThe amygdala plays a pivotal role in processing anxiety and connects to large-scale brain networks. However, intrinsic functional connectivity (iFC) between amygdala and these networks has rarely been examined in relation to anxiety, especially across the lifespan. We employed resting-state functional MRI data from 280 healthy adults (18-83.5 yrs) to elucidate the relationship between anxiety and amygdala iFC with common cortical networks including the visual network, somatomotor network, dorsal attention network, ventral attention network, limbic network, frontoparietal network, and default network. Global and network-specific iFC were separately computed as mean iFC of amygdala with the entire cerebral cortex and each cortical network. We detected negative correlation between global positive amygdala iFC and trait anxiety. Network-specific associations between amygdala iFC and anxiety were also detectable. Specifically, the higher iFC strength between the left amygdala and the limbic network predicted lower state anxiety. For the trait anxiety, left amygdala anxiety-connectivity correlation was observed in both somatomotor and dorsal attention networks, whereas the right amygdala anxiety-connectivity correlation was primarily distributed in the frontoparietal and ventral attention networks. Ventral attention network exhibited significant anxiety-gender interactions on its iFC with amygdala. Together with findings from additional vertex-wise analysis, these data clearly indicated that both low-level sensory networks and high-level associative networks could contribute to detectable predictions of anxiety behaviors by their iFC profiles with the amygdala. This set of systems neuroscience findings could lead to novel functional network models on neural correlates of human anxiety and provide targets for novel treatment strategies on anxiety disorders. Hum Brain Mapp 37:1178-1193, 2016. (c) 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
Keywordanxiety amygdala functional connectivity fMRI connectomics
DOI10.1002/hbm.23094
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program (973 Program)(2015CB351702) ; National Natural Science Foundation of China(81171409 ; Major Joint Fund for International Cooperation and Exchange of the National Natural Science Foundation(81220108014) ; National Social Science Foundation(14ZDB161) ; Chinese Academy of Sciences(KSZD-EW-TZ-002) ; 81471740)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000370243600025
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordRESTING-STATE FMRI ; INTRINSIC FUNCTIONAL CONNECTIVITY ; PREFRONTAL CORTEX ACTIVATION ; VOXEL-BASED MORPHOMETRY ; TRAIT ANXIETY ; INDIVIDUAL-DIFFERENCES ; FEARFUL FACES ; ANGRY FACES ; STRUCTURAL CONNECTIVITY ; ONSET SCHIZOPHRENIA
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19571
Collection中国科学院行为科学重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Beijing 100101, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100101, Peoples R China
5.Capital Med Univ, Beijing Friendship Hosp, Dept Rehabil Med, Beijing 100050, Peoples R China
6.Southwest Univ, Fac Psychol, Chongqing 400715, Beibei, Peoples R China
7.Guangxi Teachers Educ Univ, Sch Educ Sci, Dept Psychol, Nanning 530001, Guangxi, Peoples R China
Recommended Citation
GB/T 7714
He, Ye,Xu, Ting,Zhang, Wei,et al. Lifespan anxiety is reflected in human amygdala cortical connectivity[J]. HUMAN BRAIN MAPPING,2016,37(3):1178-1193.
APA He, Ye,Xu, Ting,Zhang, Wei,&Zuo, Xi-Nian.(2016).Lifespan anxiety is reflected in human amygdala cortical connectivity.HUMAN BRAIN MAPPING,37(3),1178-1193.
MLA He, Ye,et al."Lifespan anxiety is reflected in human amygdala cortical connectivity".HUMAN BRAIN MAPPING 37.3(2016):1178-1193.
Files in This Item:
File Name/Size DocType Version Access License
Lifespan anxiety is (868KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[He, Ye]'s Articles
[Xu, Ting]'s Articles
[Zhang, Wei]'s Articles
Baidu academic
Similar articles in Baidu academic
[He, Ye]'s Articles
[Xu, Ting]'s Articles
[Zhang, Wei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[He, Ye]'s Articles
[Xu, Ting]'s Articles
[Zhang, Wei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Lifespan anxiety is reflected in human amygdala cortical connectivity.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.