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Lifespan anxiety is reflected in human amygdala cortical connectivity
He, Ye1,2,3,4; Xu, Ting1,2,3; Zhang, Wei5; Zuo, Xi-Nian1,2,3,6,7
2016-03-01
发表期刊HUMAN BRAIN MAPPING
ISSN1065-9471
文章类型Article
卷号37期号:3页码:1178-1193
摘要The amygdala plays a pivotal role in processing anxiety and connects to large-scale brain networks. However, intrinsic functional connectivity (iFC) between amygdala and these networks has rarely been examined in relation to anxiety, especially across the lifespan. We employed resting-state functional MRI data from 280 healthy adults (18-83.5 yrs) to elucidate the relationship between anxiety and amygdala iFC with common cortical networks including the visual network, somatomotor network, dorsal attention network, ventral attention network, limbic network, frontoparietal network, and default network. Global and network-specific iFC were separately computed as mean iFC of amygdala with the entire cerebral cortex and each cortical network. We detected negative correlation between global positive amygdala iFC and trait anxiety. Network-specific associations between amygdala iFC and anxiety were also detectable. Specifically, the higher iFC strength between the left amygdala and the limbic network predicted lower state anxiety. For the trait anxiety, left amygdala anxiety-connectivity correlation was observed in both somatomotor and dorsal attention networks, whereas the right amygdala anxiety-connectivity correlation was primarily distributed in the frontoparietal and ventral attention networks. Ventral attention network exhibited significant anxiety-gender interactions on its iFC with amygdala. Together with findings from additional vertex-wise analysis, these data clearly indicated that both low-level sensory networks and high-level associative networks could contribute to detectable predictions of anxiety behaviors by their iFC profiles with the amygdala. This set of systems neuroscience findings could lead to novel functional network models on neural correlates of human anxiety and provide targets for novel treatment strategies on anxiety disorders. Hum Brain Mapp 37:1178-1193, 2016. (c) 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
关键词anxiety amygdala functional connectivity fMRI connectomics
DOI10.1002/hbm.23094
收录类别SCI
语种英语
项目资助者National Basic Research Program (973 Program)(2015CB351702) ; National Natural Science Foundation of China(81171409 ; Major Joint Fund for International Cooperation and Exchange of the National Natural Science Foundation(81220108014) ; National Social Science Foundation(14ZDB161) ; Chinese Academy of Sciences(KSZD-EW-TZ-002) ; 81471740)
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000370243600025
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]RESTING-STATE FMRI ; INTRINSIC FUNCTIONAL CONNECTIVITY ; PREFRONTAL CORTEX ACTIVATION ; VOXEL-BASED MORPHOMETRY ; TRAIT ANXIETY ; INDIVIDUAL-DIFFERENCES ; FEARFUL FACES ; ANGRY FACES ; STRUCTURAL CONNECTIVITY ; ONSET SCHIZOPHRENIA
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19571
专题中国科学院行为科学重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Beijing 100101, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100101, Peoples R China
5.Capital Med Univ, Beijing Friendship Hosp, Dept Rehabil Med, Beijing 100050, Peoples R China
6.Southwest Univ, Fac Psychol, Chongqing 400715, Beibei, Peoples R China
7.Guangxi Teachers Educ Univ, Sch Educ Sci, Dept Psychol, Nanning 530001, Guangxi, Peoples R China
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GB/T 7714
He, Ye,Xu, Ting,Zhang, Wei,et al. Lifespan anxiety is reflected in human amygdala cortical connectivity[J]. HUMAN BRAIN MAPPING,2016,37(3):1178-1193.
APA He, Ye,Xu, Ting,Zhang, Wei,&Zuo, Xi-Nian.(2016).Lifespan anxiety is reflected in human amygdala cortical connectivity.HUMAN BRAIN MAPPING,37(3),1178-1193.
MLA He, Ye,et al."Lifespan anxiety is reflected in human amygdala cortical connectivity".HUMAN BRAIN MAPPING 37.3(2016):1178-1193.
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