The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model

doi:10.1007/s10964-015-0378-x

	The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model
	Zhang, Leilei 1; Li, Zhi 2; Chen, Jie1 ; Li, Xinying1 ; Zhang, Jianxin1 ; Belsky, Jay 2
摘要	Although depressive symptoms are common during adolescence, little research has examined gene-environment interaction on youth depression. This study chose the brain-derived neurotrophic factor (BDNF) gene, tested the interaction between a functional polymorphism resulting amino acid substitution of valine (Val) to methionine (Met) in the proBDNF protein at codon 66 (Val66Met), and maternal parenting on youth depressive symptoms in a sample of 780 community adolescents of Chinese Han ethnicity (aged 11-17, M = 13.6, 51.3 % females). Participants reported their depressive symptoms and perceived maternal parenting. Results indicated the BDNF Val66Met polymorphism significantly moderated the influence of maternal warmth-reasoning, but not harshness-hostility, on youth depressive symptoms. Confirmatory model evaluation indicated that the interaction effect involving warmth-reasoning conformed to the differential-susceptibility rather than diathesis-stress model of person-X-environment interaction. Thus, Val carriers experienced less depressive symptoms than Met homozygotes when mothering was more positive but more symptoms when mothering was less positive. The findings provided evidence in support of the differential susceptibility hypothesis of youth depressive symptoms and shed light on the importance of examining the gene-environment interaction from a developmental perspective.
关键词	Adolescent depressive symptoms BDNF Val66Met polymorphism Differential susceptibility Gene-environment interaction Maternal parenting
	2016-03-01
语种	英语
DOI	10.1007/s10964-015-0378-x
发表期刊	JOURNAL OF YOUTH AND ADOLESCENCE
ISSN	0047-2891
卷号	45 期号:3 页码:471-483
期刊论文类型	Article
收录类别	SSCI
WOS关键词	GENE-ENVIRONMENT INTERACTION ; STRESSFUL LIFE EVENTS ; HPA-AXIS REACTIVITY ; CONDUCT PROBLEMS ; MAJOR DEPRESSION ; MOLECULAR-GENETICS ; MISSING DATA ; METAANALYSIS ; CHILDREN ; BEHAVIORS
WOS标题词	Social Sciences
WOS研究方向	Psychology
WOS类目	Psychology, Developmental
WOS记录号	WOS:000370072000004
资助机构	National Natural Science Foundation of China(31300841) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; BeTwiSt of Institute of Psychology, Chinese Academy of Sciences
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19572
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Univ Calif Davis, Dept Human Ecol, Davis, CA 95616 USA
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Zhang, Leilei,Li, Zhi,Chen, Jie,et al. The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model[J]. JOURNAL OF YOUTH AND ADOLESCENCE,2016,45(3):471-483.
APA	Zhang, Leilei,Li, Zhi,Chen, Jie,Li, Xinying,Zhang, Jianxin,&Belsky, Jay.(2016).The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model.JOURNAL OF YOUTH AND ADOLESCENCE,45(3),471-483.
MLA	Zhang, Leilei,et al."The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model".JOURNAL OF YOUTH AND ADOLESCENCE 45.3(2016):471-483.

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