PSYCH OpenIR  > 中国科学院心理健康重点实验室
The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model
Zhang, Leilei1; Li, Zhi2; Chen, Jie1; Li, Xinying1; Zhang, Jianxin1; Belsky, Jay2
2016-03-01
发表期刊JOURNAL OF YOUTH AND ADOLESCENCE
ISSN0047-2891
文章类型Article
卷号45期号:3页码:471-483
摘要Although depressive symptoms are common during adolescence, little research has examined gene-environment interaction on youth depression. This study chose the brain-derived neurotrophic factor (BDNF) gene, tested the interaction between a functional polymorphism resulting amino acid substitution of valine (Val) to methionine (Met) in the proBDNF protein at codon 66 (Val66Met), and maternal parenting on youth depressive symptoms in a sample of 780 community adolescents of Chinese Han ethnicity (aged 11-17, M = 13.6, 51.3 % females). Participants reported their depressive symptoms and perceived maternal parenting. Results indicated the BDNF Val66Met polymorphism significantly moderated the influence of maternal warmth-reasoning, but not harshness-hostility, on youth depressive symptoms. Confirmatory model evaluation indicated that the interaction effect involving warmth-reasoning conformed to the differential-susceptibility rather than diathesis-stress model of person-X-environment interaction. Thus, Val carriers experienced less depressive symptoms than Met homozygotes when mothering was more positive but more symptoms when mothering was less positive. The findings provided evidence in support of the differential susceptibility hypothesis of youth depressive symptoms and shed light on the importance of examining the gene-environment interaction from a developmental perspective.
关键词Adolescent depressive symptoms BDNF Val66Met polymorphism Differential susceptibility Gene-environment interaction Maternal parenting
DOI10.1007/s10964-015-0378-x
收录类别SSCI
语种英语
项目资助者National Natural Science Foundation of China(31300841) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; BeTwiSt of Institute of Psychology, Chinese Academy of Sciences
WOS研究方向Psychology
WOS类目Psychology, Developmental
WOS记录号WOS:000370072000004
WOS标题词Social Sciences
关键词[WOS]GENE-ENVIRONMENT INTERACTION ; STRESSFUL LIFE EVENTS ; HPA-AXIS REACTIVITY ; CONDUCT PROBLEMS ; MAJOR DEPRESSION ; MOLECULAR-GENETICS ; MISSING DATA ; METAANALYSIS ; CHILDREN ; BEHAVIORS
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19572
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Calif Davis, Dept Human Ecol, Davis, CA 95616 USA
推荐引用方式
GB/T 7714
Zhang, Leilei,Li, Zhi,Chen, Jie,et al. The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model[J]. JOURNAL OF YOUTH AND ADOLESCENCE,2016,45(3):471-483.
APA Zhang, Leilei,Li, Zhi,Chen, Jie,Li, Xinying,Zhang, Jianxin,&Belsky, Jay.(2016).The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model.JOURNAL OF YOUTH AND ADOLESCENCE,45(3),471-483.
MLA Zhang, Leilei,et al."The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model".JOURNAL OF YOUTH AND ADOLESCENCE 45.3(2016):471-483.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
The BDNF Val66Met Po(538KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Leilei]的文章
[Li, Zhi]的文章
[Chen, Jie]的文章
百度学术
百度学术中相似的文章
[Zhang, Leilei]的文章
[Li, Zhi]的文章
[Chen, Jie]的文章
必应学术
必应学术中相似的文章
[Zhang, Leilei]的文章
[Li, Zhi]的文章
[Chen, Jie]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。