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The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model
Zhang, Leilei1; Li, Zhi2; Chen, Jie1; Li, Xinying1; Zhang, Jianxin1; Belsky, Jay2
2016-03-01
Source PublicationJOURNAL OF YOUTH AND ADOLESCENCE
ISSN0047-2891
SubtypeArticle
Volume45Issue:3Pages:471-483
AbstractAlthough depressive symptoms are common during adolescence, little research has examined gene-environment interaction on youth depression. This study chose the brain-derived neurotrophic factor (BDNF) gene, tested the interaction between a functional polymorphism resulting amino acid substitution of valine (Val) to methionine (Met) in the proBDNF protein at codon 66 (Val66Met), and maternal parenting on youth depressive symptoms in a sample of 780 community adolescents of Chinese Han ethnicity (aged 11-17, M = 13.6, 51.3 % females). Participants reported their depressive symptoms and perceived maternal parenting. Results indicated the BDNF Val66Met polymorphism significantly moderated the influence of maternal warmth-reasoning, but not harshness-hostility, on youth depressive symptoms. Confirmatory model evaluation indicated that the interaction effect involving warmth-reasoning conformed to the differential-susceptibility rather than diathesis-stress model of person-X-environment interaction. Thus, Val carriers experienced less depressive symptoms than Met homozygotes when mothering was more positive but more symptoms when mothering was less positive. The findings provided evidence in support of the differential susceptibility hypothesis of youth depressive symptoms and shed light on the importance of examining the gene-environment interaction from a developmental perspective.
KeywordAdolescent depressive symptoms BDNF Val66Met polymorphism Differential susceptibility Gene-environment interaction Maternal parenting
DOI10.1007/s10964-015-0378-x
Indexed BySSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31300841) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; BeTwiSt of Institute of Psychology, Chinese Academy of Sciences
WOS Research AreaPsychology
WOS SubjectPsychology, Developmental
WOS IDWOS:000370072000004
WOS HeadingsSocial Sciences
WOS KeywordGENE-ENVIRONMENT INTERACTION ; STRESSFUL LIFE EVENTS ; HPA-AXIS REACTIVITY ; CONDUCT PROBLEMS ; MAJOR DEPRESSION ; MOLECULAR-GENETICS ; MISSING DATA ; METAANALYSIS ; CHILDREN ; BEHAVIORS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19572
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Calif Davis, Dept Human Ecol, Davis, CA 95616 USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang, Leilei,Li, Zhi,Chen, Jie,et al. The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model[J]. JOURNAL OF YOUTH AND ADOLESCENCE,2016,45(3):471-483.
APA Zhang, Leilei,Li, Zhi,Chen, Jie,Li, Xinying,Zhang, Jianxin,&Belsky, Jay.(2016).The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model.JOURNAL OF YOUTH AND ADOLESCENCE,45(3),471-483.
MLA Zhang, Leilei,et al."The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model".JOURNAL OF YOUTH AND ADOLESCENCE 45.3(2016):471-483.
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