Institutional Repository of Key Laboratory of Mental Health, CAS
Neural Correlates of Prospective Memory Impairments in Schizophrenia | |
Chen, Xing-jie1,2; Wang, Ya1; Wang, Yi1; Yang, Tian-xiao1; Zou, Lai-quan1,2; Huang, Jia1; Li, Feng-hua3; Chen, An-tao3; Wang, Wei-hong3; Zheng, Han-feng4; Cheung, Eric F. C.5; Shum, David H. K.6; Chan, Raymond C. K.1 | |
第一作者 | Chen, Xing-jie |
通讯作者邮箱 | wangya@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Objective: Prospective memory (PM) refers to the ability to remember to carry out intended actions after a delay. PM impairments are common in schizophrenia patients and are thought to be related to their prefrontal cortex dysfunction; however, this has not yet been examined directly in the research literature. The current study aimed to examine abnormalities in brain activation during PM task performance in schizophrenia patients. Method: Twenty-two schizophrenia patients and 25 matched healthy controls were scanned in a 3-T MRI machine while performing a PM task. Results: The results showed that compared to the healthy controls, schizophrenia patients performed significantly worse on the PM task. Furthermore, they exhibited decreased brain activation in frontal cortex including the right superior frontal gyri (Brodmann area 10), and other related brain areas like the anterior cingulate gyrus, parietal and temporal cortex, including precuneus, and some subcortext, including parahippocampal gyrus and putamen. Conclusions: These findings confirm the involvement and importance of the prefrontal cortex in PM and show evidence of hypofrontality in schizophrenia patients while performing a PM task. |
关键词 | functional imaging hypofrontality prospective memory schizophrenia |
2016-02-01 | |
语种 | 英语 |
DOI | 10.1037/neu0000225 |
发表期刊 | NEUROPSYCHOLOGY |
ISSN | 0894-4105 |
卷号 | 30期号:2页码:169-180 |
收录类别 | SCI ; SSCI |
WOS关键词 | ROSTRAL PREFRONTAL CORTEX ; WORKING-MEMORY ; EXECUTIVE FUNCTION ; FUNCTIONAL CONNECTIVITY ; DELAYED INTENTIONS ; BRAIN VOLUME ; 1ST-EPISODE SCHIZOPHRENIA ; EPISODIC MEMORY ; GYRUS VOLUME ; FMRI |
WOS标题词 | Social Sciences ; Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Psychology ; Neurosciences & Neurology |
WOS类目 | Psychology, Clinical ; Neurosciences ; Psychology |
WOS记录号 | WOS:000370070600004 |
WOS分区 | Q1 |
Q分类 | Q1 |
资助机构 | National Science Foundation of China(30900403 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(113000C136) ; Youth Innovation Promotion Association Funding of Chinese Academy of Sciences(Y1CX131003) ; Knowledge Innovation Project of the Chinese Academy of Sciences(KSCX2-EW-J-8) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/19575 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wang, Ya |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Southwest Univ, Georgetown, TX USA 4.Beibei 2 Peoples Hosp, Beibei Mental Hlth Ctr, Chongqing, Peoples R China 5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 6.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Program, Nathan, Qld 4111, Australia |
第一作者单位 | 认知与发展心理学研究室 |
通讯作者单位 | 认知与发展心理学研究室 |
推荐引用方式 GB/T 7714 | Chen, Xing-jie,Wang, Ya,Wang, Yi,et al. Neural Correlates of Prospective Memory Impairments in Schizophrenia[J]. NEUROPSYCHOLOGY,2016,30(2):169-180. |
APA | Chen, Xing-jie.,Wang, Ya.,Wang, Yi.,Yang, Tian-xiao.,Zou, Lai-quan.,...&Chan, Raymond C. K..(2016).Neural Correlates of Prospective Memory Impairments in Schizophrenia.NEUROPSYCHOLOGY,30(2),169-180. |
MLA | Chen, Xing-jie,et al."Neural Correlates of Prospective Memory Impairments in Schizophrenia".NEUROPSYCHOLOGY 30.2(2016):169-180. |
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