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Neural Correlates of Prospective Memory Impairments in Schizophrenia
Chen, Xing-jie1,2; Wang, Ya1; Wang, Yi1; Yang, Tian-xiao1; Zou, Lai-quan1,2; Huang, Jia1; Li, Feng-hua3; Chen, An-tao3; Wang, Wei-hong3; Zheng, Han-feng4; Cheung, Eric F. C.5; Shum, David H. K.6; Chan, Raymond C. K.1
2016-02-01
Source PublicationNEUROPSYCHOLOGY
ISSN0894-4105
SubtypeArticle
Volume30Issue:2Pages:169-180
AbstractObjective: Prospective memory (PM) refers to the ability to remember to carry out intended actions after a delay. PM impairments are common in schizophrenia patients and are thought to be related to their prefrontal cortex dysfunction; however, this has not yet been examined directly in the research literature. The current study aimed to examine abnormalities in brain activation during PM task performance in schizophrenia patients. Method: Twenty-two schizophrenia patients and 25 matched healthy controls were scanned in a 3-T MRI machine while performing a PM task. Results: The results showed that compared to the healthy controls, schizophrenia patients performed significantly worse on the PM task. Furthermore, they exhibited decreased brain activation in frontal cortex including the right superior frontal gyri (Brodmann area 10), and other related brain areas like the anterior cingulate gyrus, parietal and temporal cortex, including precuneus, and some subcortext, including parahippocampal gyrus and putamen. Conclusions: These findings confirm the involvement and importance of the prefrontal cortex in PM and show evidence of hypofrontality in schizophrenia patients while performing a PM task.
Keywordfunctional imaging hypofrontality prospective memory schizophrenia
DOI10.1037/neu0000225
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Science Foundation of China(30900403 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(113000C136) ; Youth Innovation Promotion Association Funding of Chinese Academy of Sciences(Y1CX131003) ; Knowledge Innovation Project of the Chinese Academy of Sciences(KSCX2-EW-J-8) ; "Strategic Priority Research Program (B)" of the Chinese Academy of Sciences(XDB02030002) ; CAS/SAFEA International Partnership Programme for Creative Research Teams(Y2CX131003) ; 81088001 ; 91132701)
WOS Research AreaPsychology ; Neurosciences & Neurology
WOS SubjectPsychology, Clinical ; Neurosciences ; Psychology
WOS IDWOS:000370070600004
WOS HeadingsSocial Sciences ; Science & Technology ; Life Sciences & Biomedicine
WOS KeywordROSTRAL PREFRONTAL CORTEX ; WORKING-MEMORY ; EXECUTIVE FUNCTION ; FUNCTIONAL CONNECTIVITY ; DELAYED INTENTIONS ; BRAIN VOLUME ; 1ST-EPISODE SCHIZOPHRENIA ; EPISODIC MEMORY ; GYRUS VOLUME ; FMRI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19575
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Southwest Univ, Georgetown, TX USA
4.Beibei 2 Peoples Hosp, Beibei Mental Hlth Ctr, Chongqing, Peoples R China
5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
6.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Program, Nathan, Qld 4111, Australia
Recommended Citation
GB/T 7714
Chen, Xing-jie,Wang, Ya,Wang, Yi,et al. Neural Correlates of Prospective Memory Impairments in Schizophrenia[J]. NEUROPSYCHOLOGY,2016,30(2):169-180.
APA Chen, Xing-jie.,Wang, Ya.,Wang, Yi.,Yang, Tian-xiao.,Zou, Lai-quan.,...&Chan, Raymond C. K..(2016).Neural Correlates of Prospective Memory Impairments in Schizophrenia.NEUROPSYCHOLOGY,30(2),169-180.
MLA Chen, Xing-jie,et al."Neural Correlates of Prospective Memory Impairments in Schizophrenia".NEUROPSYCHOLOGY 30.2(2016):169-180.
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