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Laser-evoked cortical responses in freely-moving rats reflect the activation of C-fibre afferent pathways
Xia, X. L.1,3; Peng, W. W.1,3; Iannetti, G. D.2; Hu, L.1,2,3
2016-03-01
发表期刊NEUROIMAGE
ISSN1053-8119
文章类型Article
卷号128期号:0页码:209-217
摘要The limited success of translating basic animal findings into effective clinical treatments of pain can be partly ascribed to the use of sub-optimal models. Murine models of pain often consist in recording (1) threshold responses (like the tail-flick reflex) elicited by (2) non-nociceptive specific inputs in (3) anaesthetized animals. The direct cortical recording of laser-evoked potentials (LEPs) elicited by stimuli of graded energies in freely-moving rodents avoids these three important pitfalls, and has thus the potential of improving such translation. Murine LEPs are classically reported to consist of two distinct components, reflecting the activity of Ad-and C-fibre afferent pathways. However, we have recently demonstrated that the so-called "Ad-LEPs" in fact reflect the activation of the auditory system by laser-generated ultrasounds. Here we used ongoing white noise to avoid the confound represented by the early auditory response, and thereby comprehensively characterized the physiological properties of C-fibre LEPs recorded directly from the exposed surface of the rat brain. Stimulus-response functions indicated that response amplitude is positively related to the stimulus energy, as well as to nocifensive behavioral score. When displayed using average reference, murine LEPs consist of three distinct deflections, whose polarity, order, and topography are surprisingly similar to human LEPs. The scalp topography of the early N1 wave is somatotopically-organized, likely reflecting the activity of the primary somatosensory cortex, while topographies of the later N2 and P2 waves are more centrally distributed. These results indicate that recording LEPs in freely-moving rats is a valid model to improve the translation of animal results to human physiology and pathophysiology. (C) 2016 The Authors. Published by Elsevier Inc.
关键词Pain Electrocorticography (ECoG) Animal models Ad-fibres C-fibres Laser-evoked potentials (LEPs)
DOI10.1016/j.neuroimage.2015.12.042
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31200856 ; Wellcome Trust (COLL JLARAXR) ; 31471082)
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000370386000019
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]PRIMARY SOMATOSENSORY CORTEX ; NOXIOUS MECHANICAL STIMULATION ; TAIL-FLICK REFLEX ; ANESTHETIZED RATS ; A-DELTA ; FIELD POTENTIALS ; THERMAL-STIMULATION ; SKIN TEMPERATURE ; CONSCIOUS RATS ; HAIRY SKIN
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19582
专题健康与遗传心理学研究室
作者单位1.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
2.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England
3.Southwest Univ, Fac Psychol, Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China
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Xia, X. L.,Peng, W. W.,Iannetti, G. D.,et al. Laser-evoked cortical responses in freely-moving rats reflect the activation of C-fibre afferent pathways[J]. NEUROIMAGE,2016,128(0):209-217.
APA Xia, X. L.,Peng, W. W.,Iannetti, G. D.,&Hu, L..(2016).Laser-evoked cortical responses in freely-moving rats reflect the activation of C-fibre afferent pathways.NEUROIMAGE,128(0),209-217.
MLA Xia, X. L.,et al."Laser-evoked cortical responses in freely-moving rats reflect the activation of C-fibre afferent pathways".NEUROIMAGE 128.0(2016):209-217.
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