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Laser-evoked cortical responses in freely-moving rats reflect the activation of C-fibre afferent pathways
Xia, X. L.1,3; Peng, W. W.1,3; Iannetti, G. D.2; Hu, L.1,2,3
2016-03-01
Source PublicationNEUROIMAGE
ISSN1053-8119
SubtypeArticle
Volume128Issue:0Pages:209-217
AbstractThe limited success of translating basic animal findings into effective clinical treatments of pain can be partly ascribed to the use of sub-optimal models. Murine models of pain often consist in recording (1) threshold responses (like the tail-flick reflex) elicited by (2) non-nociceptive specific inputs in (3) anaesthetized animals. The direct cortical recording of laser-evoked potentials (LEPs) elicited by stimuli of graded energies in freely-moving rodents avoids these three important pitfalls, and has thus the potential of improving such translation. Murine LEPs are classically reported to consist of two distinct components, reflecting the activity of Ad-and C-fibre afferent pathways. However, we have recently demonstrated that the so-called "Ad-LEPs" in fact reflect the activation of the auditory system by laser-generated ultrasounds. Here we used ongoing white noise to avoid the confound represented by the early auditory response, and thereby comprehensively characterized the physiological properties of C-fibre LEPs recorded directly from the exposed surface of the rat brain. Stimulus-response functions indicated that response amplitude is positively related to the stimulus energy, as well as to nocifensive behavioral score. When displayed using average reference, murine LEPs consist of three distinct deflections, whose polarity, order, and topography are surprisingly similar to human LEPs. The scalp topography of the early N1 wave is somatotopically-organized, likely reflecting the activity of the primary somatosensory cortex, while topographies of the later N2 and P2 waves are more centrally distributed. These results indicate that recording LEPs in freely-moving rats is a valid model to improve the translation of animal results to human physiology and pathophysiology. (C) 2016 The Authors. Published by Elsevier Inc.
KeywordPain Electrocorticography (ECoG) Animal models Ad-fibres C-fibres Laser-evoked potentials (LEPs)
DOI10.1016/j.neuroimage.2015.12.042
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31200856 ; Wellcome Trust (COLL JLARAXR) ; 31471082)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000370386000019
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordPRIMARY SOMATOSENSORY CORTEX ; NOXIOUS MECHANICAL STIMULATION ; TAIL-FLICK REFLEX ; ANESTHETIZED RATS ; A-DELTA ; FIELD POTENTIALS ; THERMAL-STIMULATION ; SKIN TEMPERATURE ; CONSCIOUS RATS ; HAIRY SKIN
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19582
Collection健康与遗传心理学研究室
Affiliation1.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
2.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England
3.Southwest Univ, Fac Psychol, Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China
Recommended Citation
GB/T 7714
Xia, X. L.,Peng, W. W.,Iannetti, G. D.,et al. Laser-evoked cortical responses in freely-moving rats reflect the activation of C-fibre afferent pathways[J]. NEUROIMAGE,2016,128(0):209-217.
APA Xia, X. L.,Peng, W. W.,Iannetti, G. D.,&Hu, L..(2016).Laser-evoked cortical responses in freely-moving rats reflect the activation of C-fibre afferent pathways.NEUROIMAGE,128(0),209-217.
MLA Xia, X. L.,et al."Laser-evoked cortical responses in freely-moving rats reflect the activation of C-fibre afferent pathways".NEUROIMAGE 128.0(2016):209-217.
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