Region-specific roles of the prelimbic cortex, the dorsal CA1, the ventral DG and ventral CA1 of the hippocampus in the fear return evoked by a sub-conditioning procedure in rats

doi:10.1016/j.nlm.2015.12.006

	Region-specific roles of the prelimbic cortex, the dorsal CA1, the ventral DG and ventral CA1 of the hippocampus in the fear return evoked by a sub-conditioning procedure in rats
	Fu, Juan 1,2,3; Xing, Xiaoli4 ; Han, Mengfi 1,2; Xu, Na 1,2; Piao, Chengji 1; Zhang, Yue 1,2; Zheng, Xigeng1
摘要	The return of learned fear is an important issue in anxiety disorder research since an analogous process may contribute to long-term fear maintenance or clinical relapse. A number of studies demonstrate that mPFC and hippocampus are important in the modulation of post-extinction re-expression of fear memory. However, the region-specific role of these structures in the fear return evoked by a sub-threshold conditioning (SC) is not known. In the present experiments, we first examined specific roles of the pre limbic cortex (PL), the dorsal hippocampus (DH, the dorsal CA1 area in particular), the ventral hippocampus (the ventral dentate gyrus (vDG) and the ventral CA1 area in particular) in this fear return process. Then we examined the role of connections between PL and vCA1 with this behavioral approach. Rats were subjected to five tone-shock pairings (1.0-mA shock) to induce conditioned fear (freezing), followed by three fear extinction sessions (25 tone-alone trials each session). After a post-test for extinction memory, some rats were retrained with the SC procedure to reinstate tone-evoked freezing. Rat groups were injected with low doses of the GABAA agonist muscimol to selectively inactivate PL, DH, vDG, or vCA1 120 min before the fear return test. A disconnection paradigm with ipsilateral or contralateral muscimol injection of the PL and the vCA1 was used to examine the role of this pathway in the fear return. We found that transient inactivation of these areas significantly impaired fear return (freezing): inactivation of the prelimbic cortex blocked SC-evoked fear return in particular but did not influence fear expression in general; inactivation of the DH area impaired fear return, but had no effect on the extinction retrieval process; both ventral DG and ventral CA1 are required for the return of extinguished fear whereas only ventral DG is required for the extinction retrieval. These findings suggest that PL, DH, vDG, and vCA1 all contribute to the fear return and connections between PL and vCA1 may be involved in the modulation of this process. (c) 2016 Elsevier Inc. All rights reserved.
关键词	Fear return Sub-conditioning procedure Prelimbic cortex Hippocampus
	2016-02-01
语种	英语
DOI	10.1016/j.nlm.2015.12.006
发表期刊	NEUROBIOLOGY OF LEARNING AND MEMORY
ISSN	1074-7427
卷号	128 期号:0 页码:80-91
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	MEDIAL PREFRONTAL CORTEX ; LONG-TERM POTENTIATION ; PHASEOLUS-VULGARIS-LEUKOAGGLUTININ ; CONTEXTUAL FEAR ; EXTINGUISHED FEAR ; INACTIVATION DISRUPTS ; BASOLATERAL AMYGDALA ; SPONTANEOUS-RECOVERY ; INFRALIMBIC CORTEX ; MEMORY RETRIEVAL
WOS标题词	Science & Technology ; Social Sciences ; Life Sciences & Biomedicine
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology ; Psychology
WOS类目	Behavioral Sciences ; Neurosciences ; Psychology ; Psychology, Multidisciplinary
WOS记录号	WOS:000370393200010
资助机构	Chinese Natural Science Foundation(30971057) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; Chinese Academy of Sciences(KSCX2-EW-J-8 ; Natural Science Foundation of Shandong Province(ZR2015CL025) ; Binzhou Science and Technology Development Project(2014ZC0328) ; KJZD-EW-L04-2)
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19584
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Lincui Rd 16, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Binzhou Univ, Dept Life Sci, Binzhou, Shandong, Peoples R China 4.Henan Univ, Sch Educ Sci, Kaifeng, Henan Province, Peoples R China
推荐引用方式 GB/T 7714	Fu, Juan,Xing, Xiaoli,Han, Mengfi,et al. Region-specific roles of the prelimbic cortex, the dorsal CA1, the ventral DG and ventral CA1 of the hippocampus in the fear return evoked by a sub-conditioning procedure in rats[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2016,128(0):80-91.
APA	Fu, Juan.,Xing, Xiaoli.,Han, Mengfi.,Xu, Na.,Piao, Chengji.,...&Zheng, Xigeng.(2016).Region-specific roles of the prelimbic cortex, the dorsal CA1, the ventral DG and ventral CA1 of the hippocampus in the fear return evoked by a sub-conditioning procedure in rats.NEUROBIOLOGY OF LEARNING AND MEMORY,128(0),80-91.
MLA	Fu, Juan,et al."Region-specific roles of the prelimbic cortex, the dorsal CA1, the ventral DG and ventral CA1 of the hippocampus in the fear return evoked by a sub-conditioning procedure in rats".NEUROBIOLOGY OF LEARNING AND MEMORY 128.0(2016):80-91.

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