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Region-specific roles of the prelimbic cortex, the dorsal CA1, the ventral DG and ventral CA1 of the hippocampus in the fear return evoked by a sub-conditioning procedure in rats
Fu, Juan1,2,3; Xing, Xiaoli4; Han, Mengfi1,2; Xu, Na1,2; Piao, Chengji1; Zhang, Yue1,2; Zheng, Xigeng1
AbstractThe return of learned fear is an important issue in anxiety disorder research since an analogous process may contribute to long-term fear maintenance or clinical relapse. A number of studies demonstrate that mPFC and hippocampus are important in the modulation of post-extinction re-expression of fear memory. However, the region-specific role of these structures in the fear return evoked by a sub-threshold conditioning (SC) is not known. In the present experiments, we first examined specific roles of the pre limbic cortex (PL), the dorsal hippocampus (DH, the dorsal CA1 area in particular), the ventral hippocampus (the ventral dentate gyrus (vDG) and the ventral CA1 area in particular) in this fear return process. Then we examined the role of connections between PL and vCA1 with this behavioral approach. Rats were subjected to five tone-shock pairings (1.0-mA shock) to induce conditioned fear (freezing), followed by three fear extinction sessions (25 tone-alone trials each session). After a post-test for extinction memory, some rats were retrained with the SC procedure to reinstate tone-evoked freezing. Rat groups were injected with low doses of the GABAA agonist muscimol to selectively inactivate PL, DH, vDG, or vCA1 120 min before the fear return test. A disconnection paradigm with ipsilateral or contralateral muscimol injection of the PL and the vCA1 was used to examine the role of this pathway in the fear return. We found that transient inactivation of these areas significantly impaired fear return (freezing): inactivation of the prelimbic cortex blocked SC-evoked fear return in particular but did not influence fear expression in general; inactivation of the DH area impaired fear return, but had no effect on the extinction retrieval process; both ventral DG and ventral CA1 are required for the return of extinguished fear whereas only ventral DG is required for the extinction retrieval. These findings suggest that PL, DH, vDG, and vCA1 all contribute to the fear return and connections between PL and vCA1 may be involved in the modulation of this process. (c) 2016 Elsevier Inc. All rights reserved.
KeywordFear return Sub-conditioning procedure Prelimbic cortex Hippocampus
2016-02-01
Language英语
DOI10.1016/j.nlm.2015.12.006
Source PublicationNEUROBIOLOGY OF LEARNING AND MEMORY
ISSN1074-7427
Volume128Issue:0Pages:80-91
SubtypeArticle
Indexed BySCI ; SSCI
WOS KeywordMEDIAL PREFRONTAL CORTEX ; LONG-TERM POTENTIATION ; PHASEOLUS-VULGARIS-LEUKOAGGLUTININ ; CONTEXTUAL FEAR ; EXTINGUISHED FEAR ; INACTIVATION DISRUPTS ; BASOLATERAL AMYGDALA ; SPONTANEOUS-RECOVERY ; INFRALIMBIC CORTEX ; MEMORY RETRIEVAL
WOS HeadingsScience & Technology ; Social Sciences ; Life Sciences & Biomedicine
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology ; Psychology
WOS SubjectBehavioral Sciences ; Neurosciences ; Psychology ; Psychology, Multidisciplinary
WOS IDWOS:000370393200010
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19584
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Lincui Rd 16, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Binzhou Univ, Dept Life Sci, Binzhou, Shandong, Peoples R China
4.Henan Univ, Sch Educ Sci, Kaifeng, Henan Province, Peoples R China
Recommended Citation
GB/T 7714
Fu, Juan,Xing, Xiaoli,Han, Mengfi,et al. Region-specific roles of the prelimbic cortex, the dorsal CA1, the ventral DG and ventral CA1 of the hippocampus in the fear return evoked by a sub-conditioning procedure in rats[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2016,128(0):80-91.
APA Fu, Juan.,Xing, Xiaoli.,Han, Mengfi.,Xu, Na.,Piao, Chengji.,...&Zheng, Xigeng.(2016).Region-specific roles of the prelimbic cortex, the dorsal CA1, the ventral DG and ventral CA1 of the hippocampus in the fear return evoked by a sub-conditioning procedure in rats.NEUROBIOLOGY OF LEARNING AND MEMORY,128(0),80-91.
MLA Fu, Juan,et al."Region-specific roles of the prelimbic cortex, the dorsal CA1, the ventral DG and ventral CA1 of the hippocampus in the fear return evoked by a sub-conditioning procedure in rats".NEUROBIOLOGY OF LEARNING AND MEMORY 128.0(2016):80-91.
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