Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats

doi:10.3389/fnmol.2015.00049

	Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats
	Wang, Qiong1 ; Shao, Feng 1; Wang, Weiwen2
摘要	Early life adversity, such as postnatal maternal separation (MS), play a central role in the development of psychopathologies during individual ontogeny. In this study, we investigated the effects of repeated MS (4 h per day from postnatal day (PND) 1-21) on the brain -derived neurotrophic factor (BDNF) expression in the medial prefrontal cortex (mPFC), the nucleus accumbens (NAc) and the hippocampus of male and female juvenile (PND 21), adolescent (PND 35) and young adult (PND 56) Wistar rats. The results indicated that MS increased BDNF in the CA1 and the dentate gyrus (DG) of adolescent rats as well as in the DG of young adult rats. However, the expression of BDNF in the mPFC in the young adult rats was decreased by MS. Additionally, in the hippocampus, there was decreased BDNF expression with age in both the MS and non separated rats. However, in the mPFC, the BDNF expression was increased with age in the non separated rats, nevertheless, the BDNF expression was significantly decreased in the MS young adult rats. In the NAc, the BDNF expression was increased with age in the male non -maternal separation (NMS) rats, and the young adult female MS rats had less BDNF expression than the adolescent female MS rats. The present study shows unique age differently changes on a molecular level induced by MS and advances the use of MS as a valid animal model to detect the underlying neurobiological mechanisms of mental disorders.
关键词	Maternal Separation Brain-derived Neurotrophic Factor (Bdnf) Medial Prefrontal Cortex (Mpfc) Hippocampus
	2015-09-01
语种	英语
DOI	10.3389/fnmol.2015.00049
发表期刊	FRONTIERS IN MOLECULAR NEUROSCIENCE
ISSN	1662-5099
卷号	8 期号:0 页码:49
期刊论文类型	Article
收录类别	SCI
WOS关键词	PREFRONTAL CORTEX ; BDNF EXPRESSION ; ADULT-RATS ; SOCIAL-ISOLATION ; PREPULSE INHIBITION ; NUCLEUS-ACCUMBENS ; SUBSTANTIA-NIGRA ; STRESS-RESPONSE ; WISTAR RATS ; DEPRIVATION
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000370543200001
资助机构	National Natural Science Foundation of China(31470988 ; Chinese Academy of Sciences(KJZD-LW-L04) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; 81471122)
引用统计	被引频次：37[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19585
专题	中国科学院心理健康重点实验室
作者单位	1.Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qiong,Shao, Feng,Wang, Weiwen. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE,2015,8(0):49.
APA	Wang, Qiong,Shao, Feng,&Wang, Weiwen.(2015).Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats.FRONTIERS IN MOLECULAR NEUROSCIENCE,8(0),49.
MLA	Wang, Qiong,et al."Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats".FRONTIERS IN MOLECULAR NEUROSCIENCE 8.0(2015):49.

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