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Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats
Wang, Qiong1; Shao, Feng1; Wang, Weiwen2
2015-09-01
Source PublicationFRONTIERS IN MOLECULAR NEUROSCIENCE
ISSN1662-5099
SubtypeArticle
Volume8Issue:0Pages:49
AbstractEarly life adversity, such as postnatal maternal separation (MS), play a central role in the development of psychopathologies during individual ontogeny. In this study, we investigated the effects of repeated MS (4 h per day from postnatal day (PND) 1-21) on the brain -derived neurotrophic factor (BDNF) expression in the medial prefrontal cortex (mPFC), the nucleus accumbens (NAc) and the hippocampus of male and female juvenile (PND 21), adolescent (PND 35) and young adult (PND 56) Wistar rats. The results indicated that MS increased BDNF in the CA1 and the dentate gyrus (DG) of adolescent rats as well as in the DG of young adult rats. However, the expression of BDNF in the mPFC in the young adult rats was decreased by MS. Additionally, in the hippocampus, there was decreased BDNF expression with age in both the MS and non separated rats. However, in the mPFC, the BDNF expression was increased with age in the non separated rats, nevertheless, the BDNF expression was significantly decreased in the MS young adult rats. In the NAc, the BDNF expression was increased with age in the male non -maternal separation (NMS) rats, and the young adult female MS rats had less BDNF expression than the adolescent female MS rats. The present study shows unique age differently changes on a molecular level induced by MS and advances the use of MS as a valid animal model to detect the underlying neurobiological mechanisms of mental disorders.
KeywordMaternal Separation Brain-derived Neurotrophic Factor (Bdnf) Medial Prefrontal Cortex (Mpfc) Hippocampus
DOI10.3389/fnmol.2015.00049
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31470988 ; Chinese Academy of Sciences(KJZD-LW-L04) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; 81471122)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000370543200001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordPREFRONTAL CORTEX ; BDNF EXPRESSION ; ADULT-RATS ; SOCIAL-ISOLATION ; PREPULSE INHIBITION ; NUCLEUS-ACCUMBENS ; SUBSTANTIA-NIGRA ; STRESS-RESPONSE ; WISTAR RATS ; DEPRIVATION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19585
Collection中国科学院心理健康重点实验室
Affiliation1.Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qiong,Shao, Feng,Wang, Weiwen. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE,2015,8(0):49.
APA Wang, Qiong,Shao, Feng,&Wang, Weiwen.(2015).Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats.FRONTIERS IN MOLECULAR NEUROSCIENCE,8(0),49.
MLA Wang, Qiong,et al."Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats".FRONTIERS IN MOLECULAR NEUROSCIENCE 8.0(2015):49.
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