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Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats
Wang, Qiong1; Shao, Feng1; Wang, Weiwen2
2015-09-01
发表期刊FRONTIERS IN MOLECULAR NEUROSCIENCE
ISSN1662-5099
文章类型Article
卷号8期号:0页码:49
摘要Early life adversity, such as postnatal maternal separation (MS), play a central role in the development of psychopathologies during individual ontogeny. In this study, we investigated the effects of repeated MS (4 h per day from postnatal day (PND) 1-21) on the brain -derived neurotrophic factor (BDNF) expression in the medial prefrontal cortex (mPFC), the nucleus accumbens (NAc) and the hippocampus of male and female juvenile (PND 21), adolescent (PND 35) and young adult (PND 56) Wistar rats. The results indicated that MS increased BDNF in the CA1 and the dentate gyrus (DG) of adolescent rats as well as in the DG of young adult rats. However, the expression of BDNF in the mPFC in the young adult rats was decreased by MS. Additionally, in the hippocampus, there was decreased BDNF expression with age in both the MS and non separated rats. However, in the mPFC, the BDNF expression was increased with age in the non separated rats, nevertheless, the BDNF expression was significantly decreased in the MS young adult rats. In the NAc, the BDNF expression was increased with age in the male non -maternal separation (NMS) rats, and the young adult female MS rats had less BDNF expression than the adolescent female MS rats. The present study shows unique age differently changes on a molecular level induced by MS and advances the use of MS as a valid animal model to detect the underlying neurobiological mechanisms of mental disorders.
关键词Maternal Separation Brain-derived Neurotrophic Factor (Bdnf) Medial Prefrontal Cortex (Mpfc) Hippocampus
DOI10.3389/fnmol.2015.00049
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31470988 ; Chinese Academy of Sciences(KJZD-LW-L04) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; 81471122)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000370543200001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]PREFRONTAL CORTEX ; BDNF EXPRESSION ; ADULT-RATS ; SOCIAL-ISOLATION ; PREPULSE INHIBITION ; NUCLEUS-ACCUMBENS ; SUBSTANTIA-NIGRA ; STRESS-RESPONSE ; WISTAR RATS ; DEPRIVATION
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19585
专题中国科学院心理健康重点实验室
作者单位1.Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Wang, Qiong,Shao, Feng,Wang, Weiwen. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE,2015,8(0):49.
APA Wang, Qiong,Shao, Feng,&Wang, Weiwen.(2015).Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats.FRONTIERS IN MOLECULAR NEUROSCIENCE,8(0),49.
MLA Wang, Qiong,et al."Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats".FRONTIERS IN MOLECULAR NEUROSCIENCE 8.0(2015):49.
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