rVarBase: an updated database for regulatory features of human variants

doi:10.1093/nar/gkv1107

	rVarBase: an updated database for regulatory features of human variants
	Guo, Liyuan1 ; Du, Yang 1,2; Qu, Susu 1,2; Wang, Jing1
摘要	We present here the rVarBase database (http://rv.psych.ac.cn), an updated version of the rSNPBase database, to provide reliable and detailed regulatory annotations for known and novel human variants. This update expands the database to include additional types of human variants, such as copy number variations (CNVs) and novel variants, and include additional types of regulatory features. Now rVarBase annotates variants in three dimensions: chromatin states of the surrounding regions, overlapped regulatory elements and variants' potential target genes. Two new types of regulatory elements (lncRNAs and miRNA target sites) have been introduced to provide additional annotation. Detailed information about variants' overlapping transcription factor binding sites (TFBSs) (often less than 15 bp) within experimentally supported TF-binding regions (similar to 150 bp) is provided, along with the binding motifs of matched TF families. Additional types of extended variants and variant-associated phenotypes were also added. In addition to the enrichment in data content, an element-centric search module was added, and the web interface was refined. In summary, rVarBase hosts more types of human variants and includes more types of up-to-date regulatory information to facilitate in-depth functional research and to provide practical clues for experimental design.
	2016-01-04
语种	英语
DOI	10.1093/nar/gkv1107
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
卷号	44 期号:D1 页码:D888-D893
期刊论文类型	Article
收录类别	SCI
WOS关键词	GENOMIC STRUCTURAL VARIATION ; GENE-EXPRESSION ; HUMAN-DISEASE ; INTEGRATIVE ANALYSIS ; ASSOCIATIONS ; RESOURCE ; TARGETS ; ANNOTATION ; INSIGHTS ; PROJECT
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000371261700126
资助机构	Key Laboratory of Mental Health, Institute of Psychology ; Chinese Academy of Sciences ; CAS/SAFEA International Partnership Program for Creative Research Teams(Y2CX131003) ; Chinese Academy of Sciences(KSCX2-EW-J-8) ; National Natural Science Foundation of China(81201046)
引用统计	被引频次：44[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19689
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Guo, Liyuan,Du, Yang,Qu, Susu,et al. rVarBase: an updated database for regulatory features of human variants[J]. NUCLEIC ACIDS RESEARCH,2016,44(D1):D888-D893.
APA	Guo, Liyuan,Du, Yang,Qu, Susu,&Wang, Jing.(2016).rVarBase: an updated database for regulatory features of human variants.NUCLEIC ACIDS RESEARCH,44(D1),D888-D893.
MLA	Guo, Liyuan,et al."rVarBase: an updated database for regulatory features of human variants".NUCLEIC ACIDS RESEARCH 44.D1(2016):D888-D893.

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