PSYCH OpenIR  > 中国科学院心理健康重点实验室
rVarBase: an updated database for regulatory features of human variants
Guo, Liyuan1; Du, Yang1,2; Qu, Susu1,2; Wang, Jing1
2016-01-04
Source PublicationNUCLEIC ACIDS RESEARCH
ISSN0305-1048
SubtypeArticle
Volume44Issue:D1Pages:D888-D893
AbstractWe present here the rVarBase database (http://rv.psych.ac.cn), an updated version of the rSNPBase database, to provide reliable and detailed regulatory annotations for known and novel human variants. This update expands the database to include additional types of human variants, such as copy number variations (CNVs) and novel variants, and include additional types of regulatory features. Now rVarBase annotates variants in three dimensions: chromatin states of the surrounding regions, overlapped regulatory elements and variants' potential target genes. Two new types of regulatory elements (lncRNAs and miRNA target sites) have been introduced to provide additional annotation. Detailed information about variants' overlapping transcription factor binding sites (TFBSs) (often less than 15 bp) within experimentally supported TF-binding regions (similar to 150 bp) is provided, along with the binding motifs of matched TF families. Additional types of extended variants and variant-associated phenotypes were also added. In addition to the enrichment in data content, an element-centric search module was added, and the web interface was refined. In summary, rVarBase hosts more types of human variants and includes more types of up-to-date regulatory information to facilitate in-depth functional research and to provide practical clues for experimental design.
DOI10.1093/nar/gkv1107
Indexed BySCI
Language英语
Funding OrganizationKey Laboratory of Mental Health, Institute of Psychology ; Chinese Academy of Sciences ; CAS/SAFEA International Partnership Program for Creative Research Teams(Y2CX131003) ; Chinese Academy of Sciences(KSCX2-EW-J-8) ; National Natural Science Foundation of China(81201046)
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000371261700126
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordGENOMIC STRUCTURAL VARIATION ; GENE-EXPRESSION ; HUMAN-DISEASE ; INTEGRATIVE ANALYSIS ; ASSOCIATIONS ; RESOURCE ; TARGETS ; ANNOTATION ; INSIGHTS ; PROJECT
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19689
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Guo, Liyuan,Du, Yang,Qu, Susu,et al. rVarBase: an updated database for regulatory features of human variants[J]. NUCLEIC ACIDS RESEARCH,2016,44(D1):D888-D893.
APA Guo, Liyuan,Du, Yang,Qu, Susu,&Wang, Jing.(2016).rVarBase: an updated database for regulatory features of human variants.NUCLEIC ACIDS RESEARCH,44(D1),D888-D893.
MLA Guo, Liyuan,et al."rVarBase: an updated database for regulatory features of human variants".NUCLEIC ACIDS RESEARCH 44.D1(2016):D888-D893.
Files in This Item:
File Name/Size DocType Version Access License
rVarBase_ an updated(3164KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo, Liyuan]'s Articles
[Du, Yang]'s Articles
[Qu, Susu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo, Liyuan]'s Articles
[Du, Yang]'s Articles
[Qu, Susu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo, Liyuan]'s Articles
[Du, Yang]'s Articles
[Qu, Susu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: rVarBase_ an updated database for regulatory features of human variants.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.