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Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats
Liu, Peng1,2; Zhang, JianJun1; Li, Ming3; Sui, Nan1
First AuthorLiu, Peng ; Zhang, JianJun
2016-03-15
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
SubtypeArticle
Volume10Issue:50Pages:1-10
QuartileQ1
Contribution Rank1
Abstract

5-aza-2'-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases (DNMTs), has been implicated in aversive memory and the function of brain region involved in processing emotion. However, little is known about the role of 5-aza in the reconsolidation of opiate withdrawal memory. In the present study, using the morphine-naloxone induced conditioned place aversion (CPA) model in rats, we injected 5-aza into agranular insular (AI), granular insular (GI), basolateral amygdala (BLA) and central amygdala (CeA) immediately after the memory retrieval and tested the behavioral consequences at 24 h, 7 and 14 days after retrieval test. We found that 5-aza injection into AI disrupted the reconsolidation of morphine-associated withdrawal memory, but 5-aza injection into GI had no impact on the reconsolidation. Meanwhile, 5-aza injection into BLA but not CeA attenuated the withdrawal memory trace 14 days later. However, 5-aza administration to rats, in the absence of memory reactivation, had no effect on morphine-associated withdrawal memory. These findings suggest that 5-aza interferes with the reconsolidation of opiate withdrawal memory, and the roles of insular and amygdala in reconsolidation are distinctive.

KeywordDNA methylation 5-aza-2 '-deoxycytidine morphine addiction conditioned place aversion insular amygdala
DOI10.3389/fnbeh.2016.00050
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program(2015CB553501) ; National Natural Science Foundation(91332115 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; 31170988 ; 31400880 ; 31428008)
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000371975300001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordINDUCED PLACE PREFERENCE ; LONG-TERM-MEMORY ; SYNAPTIC PLASTICITY ; LATERAL AMYGDALA ; DNA METHYLATION ; FEAR MEMORY ; DRUG MEMORY ; CORTEX ; DISRUPTION ; RETRIEVAL
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19698
Collection中国科学院心理健康重点实验室
Corresponding AuthorSui, Nan
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Liu, Peng,Zhang, JianJun,Li, Ming,et al. Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2016,10(50):1-10.
APA Liu, Peng,Zhang, JianJun,Li, Ming,&Sui, Nan.(2016).Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,10(50),1-10.
MLA Liu, Peng,et al."Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 10.50(2016):1-10.
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