PSYCH OpenIR  > 中国科学院心理健康重点实验室
Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats
Liu, Peng1,2; Zhang, JianJun1; Li, Ming3; Sui, Nan1
第一作者Liu, Peng ; Zhang, JianJun
2016-03-15
发表期刊FRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
文章类型Article
卷号10期号:50页码:1-10
Q分类Q1
产权排序1
摘要

5-aza-2'-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases (DNMTs), has been implicated in aversive memory and the function of brain region involved in processing emotion. However, little is known about the role of 5-aza in the reconsolidation of opiate withdrawal memory. In the present study, using the morphine-naloxone induced conditioned place aversion (CPA) model in rats, we injected 5-aza into agranular insular (AI), granular insular (GI), basolateral amygdala (BLA) and central amygdala (CeA) immediately after the memory retrieval and tested the behavioral consequences at 24 h, 7 and 14 days after retrieval test. We found that 5-aza injection into AI disrupted the reconsolidation of morphine-associated withdrawal memory, but 5-aza injection into GI had no impact on the reconsolidation. Meanwhile, 5-aza injection into BLA but not CeA attenuated the withdrawal memory trace 14 days later. However, 5-aza administration to rats, in the absence of memory reactivation, had no effect on morphine-associated withdrawal memory. These findings suggest that 5-aza interferes with the reconsolidation of opiate withdrawal memory, and the roles of insular and amygdala in reconsolidation are distinctive.

关键词DNA methylation 5-aza-2 '-deoxycytidine morphine addiction conditioned place aversion insular amygdala
DOI10.3389/fnbeh.2016.00050
收录类别SCI
语种英语
项目资助者National Basic Research Program(2015CB553501) ; National Natural Science Foundation(91332115 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; 31170988 ; 31400880 ; 31428008)
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000371975300001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]INDUCED PLACE PREFERENCE ; LONG-TERM-MEMORY ; SYNAPTIC PLASTICITY ; LATERAL AMYGDALA ; DNA METHYLATION ; FEAR MEMORY ; DRUG MEMORY ; CORTEX ; DISRUPTION ; RETRIEVAL
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19698
专题中国科学院心理健康重点实验室
通讯作者Sui, Nan
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
推荐引用方式
GB/T 7714
Liu, Peng,Zhang, JianJun,Li, Ming,et al. Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2016,10(50):1-10.
APA Liu, Peng,Zhang, JianJun,Li, Ming,&Sui, Nan.(2016).Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,10(50),1-10.
MLA Liu, Peng,et al."Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 10.50(2016):1-10.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2016 fnbeh Distincti(2216KB)期刊论文出版稿暂不开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Peng]的文章
[Zhang, JianJun]的文章
[Li, Ming]的文章
百度学术
百度学术中相似的文章
[Liu, Peng]的文章
[Zhang, JianJun]的文章
[Li, Ming]的文章
必应学术
必应学术中相似的文章
[Liu, Peng]的文章
[Zhang, JianJun]的文章
[Li, Ming]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。