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Frequency-Dependent Brain Regional Homogeneity Alterations in Patients with Mild Cognitive Impairment during Working Memory State Relative to Resting State
Wang, Pengyun1; Li, Rui1; Yu, Jing2; Huang, Zirui3; Li, Juan1
第一作者Wang, Pengyun
2016-03-24
发表期刊FRONTIERS IN AGING NEUROSCIENCE
ISSN1663-4365
文章类型Article
卷号8期号:0页码:60
Q分类Q1
产权排序1
摘要

Several studies have reported working memory deficits in patients with mild cognitive impairment (MCI). However, previous studies investigating the neural mechanisms of MCI have primarily focused on brain activity alterations during working memory tasks. No study to date has compared brain network alterations in the working memory state between MCI patients and normal control (NC) subjects. Therefore, using the index of regional homogeneity (ReHo), we explored brain network impairments in MCI patients during a working memory task relative to the resting state, and identified frequency dependent effects in separate frequency bands. Our results indicate that, in MCI patients, ReHo is altered in the posterior cingulate cortex (PCC) in the slow-3 band (0.073-0.198 Hz), and in the bottom of the right occipital lobe and part of the right cerebellum, the right thalamus, a diffusing region in the bilateral prefrontal cortex (PFC), the left and right parietal occipital regions, and the right angular gyrus in the slow-5 band (0.01-0.027 Hz). Furthermore, in NCs, the value of ReHo in clusters belonging to the default mode network (DMN) decreased, while the value of ReHo in clusters belonging to the attentional network increased during the task state. However, this pattern was reversed in MCI patients, and was associated with decreased working memory performance. In addition, we identified altered functional connectivity of the above mentioned regions with other parts of the brain in MCI patients. This is the first study to compare frequency-dependent alterations of ReHo in MCI patients between resting and working memory states. The results provide a new perspective regarding the neural mechanisms of working memory deficits in MCI patients, and extend our knowledge of altered brain patterns in resting and task-evoked states.

关键词mild cognitive impairment working memory state regional homogeneity frequency bands
DOI10.3389/fnagi.2016.00060
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31271108 ; National Science and Technology Pillar Program of China(2009BAI77B03) ; Knowledge Innovation Project of the Chinese Academy of Sciences(KSCX2-EW-J-8) ; CAS/SAFEA International Partnership Program for Creative Research Team(Y2CX131003) ; Institute of psychology, Chinese Academy of Sciences(1110000038 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2014ZK02 ; 30911120494 ; Y3CX151005) ; KLMH2014ZG10) ; 31070916 ; 31400895)
WOS研究方向Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目Geriatrics & Gerontology ; Neurosciences
WOS记录号WOS:000372589300001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; TASK ; NETWORKS ; OSCILLATIONS ; ATTENTION ; DEMENTIA ; SYNCHRONIZATION ; PATTERNS ; CORTEX
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19700
专题中国科学院心理健康重点实验室
通讯作者Li, Juan
作者单位1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
3.Univ Ottawa, Inst Mental Hlth Res, Ottawa, ON, Canada
推荐引用方式
GB/T 7714
Wang, Pengyun,Li, Rui,Yu, Jing,et al. Frequency-Dependent Brain Regional Homogeneity Alterations in Patients with Mild Cognitive Impairment during Working Memory State Relative to Resting State[J]. FRONTIERS IN AGING NEUROSCIENCE,2016,8(0):60.
APA Wang, Pengyun,Li, Rui,Yu, Jing,Huang, Zirui,&Li, Juan.(2016).Frequency-Dependent Brain Regional Homogeneity Alterations in Patients with Mild Cognitive Impairment during Working Memory State Relative to Resting State.FRONTIERS IN AGING NEUROSCIENCE,8(0),60.
MLA Wang, Pengyun,et al."Frequency-Dependent Brain Regional Homogeneity Alterations in Patients with Mild Cognitive Impairment during Working Memory State Relative to Resting State".FRONTIERS IN AGING NEUROSCIENCE 8.0(2016):60.
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