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BDNF Val66Met 基因多态性和母亲教养 对青少年抑郁症状的影响
Alternative TitleEffect of Maternal Parenting Styles and BDNF Val66Met Polymorphism on Adolescents Depressive Symptoms
Thesis Advisor李新影
Degree Grantor中国科学院研究生院
Place of Conferral北京
Degree Discipline心理学
Keyword青少年 抑郁症状 母亲教养 行为遗传学
既有研究ᨀ示,在青少年抑郁症状的发生机制中,既有环境因素的影响作用,又有遗传因素贡献的个体差异。本研究从母亲教养这一重要的环境变量入手,通过因子分析将母亲教养ᨀ炼出正性教养与负性教养两因子,并从维度说与模式说两个角度分别探讨了母亲教养因子与组合而成的母亲教养模式对青少年抑郁症状的相关与因果关系。在此基础上,从行为遗传学视角引入BDNF Val66Met基因多态性这一遗传易感性因素,考察遗传环境的交互作用。通过G×E Interaction的模式,进一步检验“素质-压力模型”与“差异易感性模型”。
(2)母亲正性教养与BDNF Val66Met基因多态性对青少年抑郁症状有显著地交互作用,交互模式符合“差异易感性模型”,Val等位基因为“可塑性基因”。
(3)母亲正性教养、负性教养、BDNF Val66Met基因型的三项交互项显著,而基因型与母亲正性教养的交互作用仅在高水平母亲负性教养下显著。
Other Abstract Adolescence is an inevitable “risky”  period for individuals, with full opportunities  of  both rapid growth and  intense crises. To the age of 18, nearly quarter of teens experience significantly clinical depressive symptoms, including depressed mood, sleep disorder, et al. Concerning learning disabilities, suicide intention, and clinical MDD in adulthood, depressive symptom is called for abundant researches  on its occurrence and mechanism for further prevention of  depression.
Based on the knowledge that both environment and genetics contribute to  the variance, the present study intended to investigate how maternal parenting and BDNF Val66Met polymorphism would influence adolescents depressive symptoms. Firstly, with factor analysis of maternal  parenting dimensions, we got 2 main factors——Mother Positive & Mother Negative.Then, effect of maternal parenting on child depressive symptoms were explored by correlation and regression tests from both factor and pattern perspectives.
Thirdly, utilizing behavioral genetic methods, we  demonstrated the interaction between maternal parenting and genetic factor.
The main findings were listed below:
1. Mother Positive,Mother Negative, Maternal Parenting Pattern are all significant indicators to adolescent depressive symptoms. Mother  Positive is negatively correlated with depressive symptoms, while Mother Negative is correlated positively.Among all the 4 patterns of maternal parenting, the type of “Warm”, with higher level of MP and lower level of MN, scored significantly lowest in CDI.
2. There is a significant interaction between Mother Positive and BDNF Val66Met Polymorphism on adolescent depressive symptoms. And the pattern fits “Differential Susceptibility Model” better, while Val allele acts as susceptible gene.
3. A three-way interaction is also detected among Mother Positive, Mother Negative, and BDNF Val66Met polymorphism on CDI scores. Furthermore, Interaction between MP and polymorphism is only observed under lower level of Mother  Negative circumstance. 
Subject Area行为遗传学
Document Type学位论文
Recommended Citation
GB/T 7714
张璠. BDNF Val66Met 基因多态性和母亲教养 对青少年抑郁症状的影响[D]. 北京. 中国科学院研究生院,2015.
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