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抑郁易感与应激抵抗的多巴胺神经机制
Alternative TitleResearch on the role of dopamine in depressionsusceptibilityand stress resilience
郑伦
Subtype博士
Thesis Advisor郑希耕
2011-12
Degree Grantor中国科学院研究生院
Place of Conferral北京
Degree Discipline心理学
Keyword抑郁 应激抵抗 抑郁易感 慢性不确定性应激 强迫游泳 多巴胺
Abstract众多临床和基础研究提示,在相同应激处理下,部分个体会罹患精神疾病,部分个体通过有效的调控机制,可以在应激结束后及时终止应激反应,恢复内平衡状态。为探讨多巴胺系统在抑郁易感与应激抵抗中的作用,进一步明确多巴胺在抑郁发生中的病理生理机制,采用国际上通用的“慢性不确定性应激”以及“强迫游泳”动物模型,考察在急性强迫游泳处理下,漂浮样被动应对方式对于不确定性慢性应激处理后的快感缺失是否具有预测作用;以及多巴胺第2、3受体亚型激动剂Ropinirole对于漂浮行为和快感缺失行为的调节作用及其伏核神经机制。
主要结果如下:
1  15分钟强迫游泳前处理中最后5分钟的漂浮行为可以作为筛选动物抑郁样行为的重要指标;
2  在急性强迫游泳处理下以“漂浮行为”作为应对方式的易感动物,在随后的慢性不确定性应激处理下更容易出现快感缺失;
3  一周大体注射或糖水偏爱测试前30分钟伏核脑区注射Ropinirole,都可以有效逆转快感缺失动物的糖水偏爱值;
4 一周大体注射或强迫游泳测试前30分钟伏核脑区注射Ropinirole具有减少急性强迫游泳处理下易感动物漂浮行为的作用。
以上结果提示,急性应激处理下表现出“行为绝望样”的“状态性抑郁”动物在慢性不确定性应激处理下更容易出现“快感缺失”的“体质性抑郁”。这说明漂浮行为作为一种被动防御方式,是易感个体在急性应激下倾向于采用的防御应对方式;同时这类动物在长期应激处理下更容易出现快感缺失。此外,多巴胺2、3受体亚型在漂浮行为和快感缺失中发挥重要作用。
Other AbstractMental disorders have known environmental causes,but there is heterogeneity in the response to each causal factor, which gene–environment findings attribute to genetic differences. Resilience can be viewed as a defence mechanism, which enables people to thrive in the face of adversity.The present study aims to explore the dopamine mechanismof stress resilienceand depressionsusceptibility. Then, by using chronic unpredictablestressand forced swin stress animal model, we explored the relationship of immobile behaviorwith anhedonia.In order to further investigate the role of dopamine in behavioral despairand anhedonia,by usingbehavioral pharmacologymethods,we examined the roleof D2/3receptor on immobile and anhedonia. The main results are follows:
1.Theimmobile behaviorof the last 5min of pretestis the importantbehavioral indicatorof identifyingdepressionsusceptibilityduring forced swim test.
2.The decreased sucrose preference after CUS treatment can,at least in part, be attributed to the passive defenseduring acute forced swimstress.
3.D2/3 receptor agonistRopiniroleincreased sucrose preference of stressed rats whichexhibitanhedoniaafter CUS treatment.
4.D2/3 receptor agonistRopiniroledecreased immobile of stressed rats after FST treatment..
Subject Area医学心理学
Language中文
Document Type学位论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19784
Collection健康与遗传心理学研究室
Affiliation中国科学院心理研究所
Recommended Citation
GB/T 7714
郑伦. 抑郁易感与应激抵抗的多巴胺神经机制[D]. 北京. 中国科学院研究生院,2011.
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