人脑局部功能一致性:毕生发展和智力关联

PSYCH OpenIR > 认知与发展心理学研究室

	人脑局部功能一致性:毕生发展和智力关联
其他题名	Local Functional Homogeneity of the Human Brain: Lifespan Development and Intelligence Association
	张喆
	2014
摘要	人脑局部功能一致性刻画脑功能活动同步强度，反映脑功能活动空间分布边界。基于皮层的局部功能一致性测量的是皮层上一个顶点与其相邻点之间血氧依赖水平(BOLD)信号活动的肯德尔系数，是对灰质神经元活动的间接测量。局部功能一致性指标不仅具有很高的重测信度，而且有着重要的神经生物学意义和结构基础;它能够反映大脑皮层处理信息的复杂程度或功能加工等级。目前尚缺乏对局部功能一致性的毕生发展和行为关联的研究。本论文包括两个研究，一是局部功能一致性的毕生发展轨线，二是局部功能一致性与智力的关联。结果发现:1)在双侧颗上回，局部功能一致性与年龄呈线性正相关，随着毕生进程，该区域局部功能一致性升高;在双侧前扣带回、内侧额上回、右侧前中央沟上部、脑岛，则呈现与年龄的线性负相关，随着年龄的增长，这些区域局部功能一致性显著降低;2)男性的额下回、前中央沟下部和颗上回局部功能一致性显著高于女性，女性则在下顶沟、后扣带回和楔前叶表现出更高的局部功能一致性;3)在右侧枕上回和楔叶回，男女表现出不同的毕生发展轨线，女性这些区域的局部功能一致性随年龄变高，而男性则正好相反;4)双侧中央沟和中央后回的局部功能一致性呈现倒U型毕生发展轨线，而右侧梭状回的局部功能功能一致性的毕生发展则符合U型变化轨线;5)左侧额中回和额上回的局部功能一致性与总智商负相关，言语智商与局部功能一致性在中央运动皮层成负相关，而与右侧额中回和双侧缘上回的局部功能一致性呈正相关。本研究为深入理解人脑局部功能活动的毕生发展、性别差异及其与智力的关系提供了初步的实验室数据。
其他摘要	Human brain's local functional homogeneity characterizes the strength of regionally functional synchronization, and reflects the boundary of functionally heterogeneous regions. Surface-based regional homogeneity (2dReHo) measures the neural activity in gray matter, and it defines the Kendall's coefficient of a given vertex and its nearest neighbors. 2dReHo has been demonstrated highly test-retest reliable, and been with the neurobiological significance and structural basis. It represents the complexity or functional hierarchy of information processing. Few studies have investigated the lifespan development of 2dReHo and its behavior associations. This study aimed to examine the lifespan development trajectories of 2dReHo by using both linear and quadratic models as well as the intelligence association of 2dReHo. The results showed that, 1) Positive correlations between age and 2dReHo across the lifespan (6一85 years) were detected in bilateral superior temporal gyros, which means 2dReHo in these regions increase with age; Regions showed reduced 2dReHo with age include bilateral anterior cingulate, medial superior frontal gyros, right superior part of precentral sulcus, and insular 2) Men showed higher 2dReHo in the inferior frontal gyros, inferior part of precentral sulcus and superior temporal gyros, while women have higher 2dReHo in inferior parietal sulcus, posterior cingulate gyros and precuneus; 3) Different lifespan development trajectories of 2dReHo were found in right occipital gyros and cuneus gyros. Female showed increased 2dReHo in these regions while male presented opposite trend; 4) Negative quadratic trajectories (the inverted U-shaped curve) of 2dReHo was observed in the regions of bilateral central sulcus and postcentral gyros. We also found a positive quadratic trajectory (the U一shaped curve) in the right fusiform gyros; 5) 2dReHo in the left superior and middle frontal gyros showed negative correlations with FSIQ whereas the verbal IQ exhibited negative correlation with 2dReHo in central motor cortex and positive correlations in the right middle frontal gyros and bilateral superamarginal gyros. This study provided some preliminary laboratory data for further understanding of human brain's local functional activity, its lifespan development trajectory, gender difference, and the association with intelligence.
学科领域	认知神经科学
关键词	局部功能一致性毕生发展智力静息态功能磁共振
学位类型	硕士
语种	中文
学位专业	认知神经科学
学位授予单位	中国科学院大学
学位授予地点	北京
文献类型	学位论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19800
专题	认知与发展心理学研究室
作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	张喆. 人脑局部功能一致性:毕生发展和智力关联[D]. 北京. 中国科学院大学,2014.

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