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Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews
Duan, Ying1,2; Shen, Fang1; Gu, Tingting1,2; Sui, Nan1
2016-06-07
发表期刊FRONTIERS IN PSYCHOLOGY
ISSN1664-1078
文章类型Article
卷号7期号:0页码:816
摘要Drug addiction is viewed as a maladaptive memory induced by contextual cues even in the abstinent state. However, the variations of hedonia and appetite induced by the context during the abstinence have been neglected. To distinguish the representative behaviors between hedonia and appetite, micro-behaviors in abstinent animal such as psycho-activity and drug seeking behaviors were observed in morphine conditioned place preference (CPP). To confirm the different effects of reward between drug and natural reward, a palatable food CPP paradigm was compared in current work. After a 10-day training in CPP with morphine or food, the preference was tested on day 1, 14, 28, and the changes of micro-behaviors were analyzed further. Our data showed that tree shrews treated with morphine performed more jumps on day 1 and more visits to saline paired side on day 28, which indicated a featured behavioral transition from psycho-activity to seeking behavior during drug abstinence. Meanwhile, food conditioned animals only displayed obvious seeking behaviors in the three tests. The results suggest that the variations of micro-behaviors could imply such a transition from hedonic response to appetitive behaviors during morphine abstinence, which provided a potential behavioral basis for further neural mechanism studies.
关键词Tree Shrews Addiction Morphine Cpp Micro-behaviors Transition Palatable Food
DOI10.3389/fpsyg.2016.00816
收录类别SSCI
语种英语
项目资助者National Basic Research Program Grants(2015CB553501) ; National Natural Science Foundation(31170988) ; Natural Science Foundation Major Research Plan program(91332115) ; Natural Science Foundation Youth program(31500893) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS研究方向Psychology
WOS类目Psychology, Multidisciplinary
WOS记录号WOS:000377254100001
WOS标题词Social Sciences
关键词[WOS]CONDITIONED PLACE PREFERENCE ; GOAL-DIRECTED BEHAVIORS ; NUCLEUS-ACCUMBENS ; GLUTAMATE TRANSMISSION ; INCENTIVE SALIENCE ; COCAINE ADDICTION ; REWARD CIRCUITRY ; DRUG-ADDICTION ; NEURAL SYSTEMS ; FOOD REWARD
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19942
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
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Duan, Ying,Shen, Fang,Gu, Tingting,et al. Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews[J]. FRONTIERS IN PSYCHOLOGY,2016,7(0):816.
APA Duan, Ying,Shen, Fang,Gu, Tingting,&Sui, Nan.(2016).Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews.FRONTIERS IN PSYCHOLOGY,7(0),816.
MLA Duan, Ying,et al."Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews".FRONTIERS IN PSYCHOLOGY 7.0(2016):816.
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