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Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews | |
Duan, Ying1,2; Shen, Fang1; Gu, Tingting1,2; Sui, Nan1 | |
摘要 | Drug addiction is viewed as a maladaptive memory induced by contextual cues even in the abstinent state. However, the variations of hedonia and appetite induced by the context during the abstinence have been neglected. To distinguish the representative behaviors between hedonia and appetite, micro-behaviors in abstinent animal such as psycho-activity and drug seeking behaviors were observed in morphine conditioned place preference (CPP). To confirm the different effects of reward between drug and natural reward, a palatable food CPP paradigm was compared in current work. After a 10-day training in CPP with morphine or food, the preference was tested on day 1, 14, 28, and the changes of micro-behaviors were analyzed further. Our data showed that tree shrews treated with morphine performed more jumps on day 1 and more visits to saline paired side on day 28, which indicated a featured behavioral transition from psycho-activity to seeking behavior during drug abstinence. Meanwhile, food conditioned animals only displayed obvious seeking behaviors in the three tests. The results suggest that the variations of micro-behaviors could imply such a transition from hedonic response to appetitive behaviors during morphine abstinence, which provided a potential behavioral basis for further neural mechanism studies. |
关键词 | Tree Shrews Addiction Morphine Cpp Micro-behaviors Transition Palatable Food |
2016-06-07 | |
语种 | 英语 |
DOI | 10.3389/fpsyg.2016.00816 |
发表期刊 | FRONTIERS IN PSYCHOLOGY |
ISSN | 1664-1078 |
卷号 | 7期号:0页码:816 |
期刊论文类型 | Article |
收录类别 | SSCI |
WOS关键词 | CONDITIONED PLACE PREFERENCE ; GOAL-DIRECTED BEHAVIORS ; NUCLEUS-ACCUMBENS ; GLUTAMATE TRANSMISSION ; INCENTIVE SALIENCE ; COCAINE ADDICTION ; REWARD CIRCUITRY ; DRUG-ADDICTION ; NEURAL SYSTEMS ; FOOD REWARD |
WOS标题词 | Social Sciences |
WOS研究方向 | Psychology |
WOS类目 | Psychology, Multidisciplinary |
WOS记录号 | WOS:000377254100001 |
资助机构 | National Basic Research Program Grants(2015CB553501) ; National Natural Science Foundation(31170988) ; Natural Science Foundation Major Research Plan program(91332115) ; Natural Science Foundation Youth program(31500893) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/19942 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室; 中国科学院心理研究所 |
推荐引用方式 GB/T 7714 | Duan, Ying,Shen, Fang,Gu, Tingting,et al. Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews[J]. FRONTIERS IN PSYCHOLOGY,2016,7(0):816. |
APA | Duan, Ying,Shen, Fang,Gu, Tingting,&Sui, Nan.(2016).Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews.FRONTIERS IN PSYCHOLOGY,7(0),816. |
MLA | Duan, Ying,et al."Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews".FRONTIERS IN PSYCHOLOGY 7.0(2016):816. |
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Addiction_ From Cont(1076KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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