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Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews
Duan, Ying1,2; Shen, Fang1; Gu, Tingting1,2; Sui, Nan1
AbstractDrug addiction is viewed as a maladaptive memory induced by contextual cues even in the abstinent state. However, the variations of hedonia and appetite induced by the context during the abstinence have been neglected. To distinguish the representative behaviors between hedonia and appetite, micro-behaviors in abstinent animal such as psycho-activity and drug seeking behaviors were observed in morphine conditioned place preference (CPP). To confirm the different effects of reward between drug and natural reward, a palatable food CPP paradigm was compared in current work. After a 10-day training in CPP with morphine or food, the preference was tested on day 1, 14, 28, and the changes of micro-behaviors were analyzed further. Our data showed that tree shrews treated with morphine performed more jumps on day 1 and more visits to saline paired side on day 28, which indicated a featured behavioral transition from psycho-activity to seeking behavior during drug abstinence. Meanwhile, food conditioned animals only displayed obvious seeking behaviors in the three tests. The results suggest that the variations of micro-behaviors could imply such a transition from hedonic response to appetitive behaviors during morphine abstinence, which provided a potential behavioral basis for further neural mechanism studies.
KeywordTree Shrews Addiction Morphine Cpp Micro-behaviors Transition Palatable Food
2016-06-07
Language英语
DOI10.3389/fpsyg.2016.00816
Source PublicationFRONTIERS IN PSYCHOLOGY
ISSN1664-1078
Volume7Issue:0Pages:816
SubtypeArticle
Indexed BySSCI
WOS KeywordCONDITIONED PLACE PREFERENCE ; GOAL-DIRECTED BEHAVIORS ; NUCLEUS-ACCUMBENS ; GLUTAMATE TRANSMISSION ; INCENTIVE SALIENCE ; COCAINE ADDICTION ; REWARD CIRCUITRY ; DRUG-ADDICTION ; NEURAL SYSTEMS ; FOOD REWARD
WOS HeadingsSocial Sciences
WOS Research AreaPsychology
WOS SubjectPsychology, Multidisciplinary
WOS IDWOS:000377254100001
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19942
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS;  Institute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Duan, Ying,Shen, Fang,Gu, Tingting,et al. Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews[J]. FRONTIERS IN PSYCHOLOGY,2016,7(0):816.
APA Duan, Ying,Shen, Fang,Gu, Tingting,&Sui, Nan.(2016).Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews.FRONTIERS IN PSYCHOLOGY,7(0),816.
MLA Duan, Ying,et al."Addiction: From Context-Induced Hedonia to Appetite, Based on Transition of Micro-behaviors in Morphine Abstinent Tree Shrews".FRONTIERS IN PSYCHOLOGY 7.0(2016):816.
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