Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System

doi:10.1155/2016/6530364

	Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System
	Li, Jian 1; Liu, Qian-tong 1; Chen, Yi 1; Liu, Jie 1; Shi, Jin-li 1; Liu, Yong 1; Guo, Jian-you2
摘要	Quercitrin is a well-known flavonoid that is contained in Flos Albiziae, which has been used for the treatment of anxiety. The present study investigated the anxiolytic-like effects of quercitrin in experimental models of anxiety. Compared with the control group, repeated treatment with quercitrin (5.0 and 10.0mg/kg/day, p.o.) for seven days significantly increased the percentage of entries into and time spent on the open arms of the elevated plus maze. In the light/dark box test, quercitrin exerted an anxiolytic-like effect at 5 and 10mg/kg. In the marble-burying test, quercitrin (5.0 and 10.0mg/kg) also exerted an anxiolytic-like effect. Furthermore, quercitrin did not affect spontaneous locomotor activity. The anxiolytic-like effects of quercitrin in the elevated plus maze and light/dark box test were blocked by the serotonin-1A (5-hydroxytryptamine-1A (5-HT1A)) receptor antagonist WAY-100635 (3.0 mg/kg, i.p.) but not by the gamma-aminobutyric acid-A (GABA(A)) receptor antagonist flumazenil (0.5 mg/kg, i.p.). The levels of brainmonoamines (5-HT and dopamine) and their metabolites (5-hydroxy-3-indoleacetic acid, 3,4-dihydroxyphenylacetic acid, and homovanillic acid) were decreased after quercitrin treatment. These data suggest that the anxiolytic-like effects of quercitrin might be mediated by 5-HT1A receptors but not by benzodiazepine site of GABA(A) receptors. The results of the neurochemical studies suggest that these effects are mediated by modulation of the levels of monoamine neurotransmitters.
	2016
语种	英语
DOI	10.1155/2016/6530364
发表期刊	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN	1741-427X
卷号	0 期号:0 页码:1-10
期刊论文类型	Article
收录类别	SCI
WOS关键词	ELEVATED PLUS-MAZE ; ALBIZZIA-JULIBRISSIN ; ANXIETY DISORDERS ; MICE ; RATS ; ANTAGONIST ; WAY-100635 ; GLYCOSIDES ; RESPONSES ; BEHAVIOR
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Integrative & Complementary Medicine
WOS类目	Integrative & Complementary Medicine
WOS记录号	WOS:000376946500001
资助机构	Ministry of Science and Technology(2012ZX09102201-018)
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19943
专题	中国科学院心理健康重点实验室
作者单位	1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Li, Jian,Liu, Qian-tong,Chen, Yi,et al. Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2016,0(0):1-10.
APA	Li, Jian.,Liu, Qian-tong.,Chen, Yi.,Liu, Jie.,Shi, Jin-li.,...&Guo, Jian-you.(2016).Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,0(0),1-10.
MLA	Li, Jian,et al."Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 0.0(2016):1-10.

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