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Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System
Li, Jian1; Liu, Qian-tong1; Chen, Yi1; Liu, Jie1; Shi, Jin-li1; Liu, Yong1; Guo, Jian-you2
2016
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
SubtypeArticle
Volume0Issue:0Pages:1-10
AbstractQuercitrin is a well-known flavonoid that is contained in Flos Albiziae, which has been used for the treatment of anxiety. The present study investigated the anxiolytic-like effects of quercitrin in experimental models of anxiety. Compared with the control group, repeated treatment with quercitrin (5.0 and 10.0mg/kg/day, p.o.) for seven days significantly increased the percentage of entries into and time spent on the open arms of the elevated plus maze. In the light/dark box test, quercitrin exerted an anxiolytic-like effect at 5 and 10mg/kg. In the marble-burying test, quercitrin (5.0 and 10.0mg/kg) also exerted an anxiolytic-like effect. Furthermore, quercitrin did not affect spontaneous locomotor activity. The anxiolytic-like effects of quercitrin in the elevated plus maze and light/dark box test were blocked by the serotonin-1A (5-hydroxytryptamine-1A (5-HT1A)) receptor antagonist WAY-100635 (3.0 mg/kg, i.p.) but not by the gamma-aminobutyric acid-A (GABA(A)) receptor antagonist flumazenil (0.5 mg/kg, i.p.). The levels of brainmonoamines (5-HT and dopamine) and their metabolites (5-hydroxy-3-indoleacetic acid, 3,4-dihydroxyphenylacetic acid, and homovanillic acid) were decreased after quercitrin treatment. These data suggest that the anxiolytic-like effects of quercitrin might be mediated by 5-HT1A receptors but not by benzodiazepine site of GABA(A) receptors. The results of the neurochemical studies suggest that these effects are mediated by modulation of the levels of monoamine neurotransmitters.
DOI10.1155/2016/6530364
Indexed BySCI
Language英语
Funding OrganizationMinistry of Science and Technology(2012ZX09102201-018)
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000376946500001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordELEVATED PLUS-MAZE ; ALBIZZIA-JULIBRISSIN ; ANXIETY DISORDERS ; MICE ; RATS ; ANTAGONIST ; WAY-100635 ; GLYCOSIDES ; RESPONSES ; BEHAVIOR
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19943
Collection中国科学院心理健康重点实验室
Affiliation1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Li, Jian,Liu, Qian-tong,Chen, Yi,et al. Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2016,0(0):1-10.
APA Li, Jian.,Liu, Qian-tong.,Chen, Yi.,Liu, Jie.,Shi, Jin-li.,...&Guo, Jian-you.(2016).Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,0(0),1-10.
MLA Li, Jian,et al."Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 0.0(2016):1-10.
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