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Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System
Li, Jian1; Liu, Qian-tong1; Chen, Yi1; Liu, Jie1; Shi, Jin-li1; Liu, Yong1; Guo, Jian-you2
2016
发表期刊EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
文章类型Article
卷号0期号:0页码:1-10
摘要Quercitrin is a well-known flavonoid that is contained in Flos Albiziae, which has been used for the treatment of anxiety. The present study investigated the anxiolytic-like effects of quercitrin in experimental models of anxiety. Compared with the control group, repeated treatment with quercitrin (5.0 and 10.0mg/kg/day, p.o.) for seven days significantly increased the percentage of entries into and time spent on the open arms of the elevated plus maze. In the light/dark box test, quercitrin exerted an anxiolytic-like effect at 5 and 10mg/kg. In the marble-burying test, quercitrin (5.0 and 10.0mg/kg) also exerted an anxiolytic-like effect. Furthermore, quercitrin did not affect spontaneous locomotor activity. The anxiolytic-like effects of quercitrin in the elevated plus maze and light/dark box test were blocked by the serotonin-1A (5-hydroxytryptamine-1A (5-HT1A)) receptor antagonist WAY-100635 (3.0 mg/kg, i.p.) but not by the gamma-aminobutyric acid-A (GABA(A)) receptor antagonist flumazenil (0.5 mg/kg, i.p.). The levels of brainmonoamines (5-HT and dopamine) and their metabolites (5-hydroxy-3-indoleacetic acid, 3,4-dihydroxyphenylacetic acid, and homovanillic acid) were decreased after quercitrin treatment. These data suggest that the anxiolytic-like effects of quercitrin might be mediated by 5-HT1A receptors but not by benzodiazepine site of GABA(A) receptors. The results of the neurochemical studies suggest that these effects are mediated by modulation of the levels of monoamine neurotransmitters.
DOI10.1155/2016/6530364
收录类别SCI
语种英语
项目资助者Ministry of Science and Technology(2012ZX09102201-018)
WOS研究方向Integrative & Complementary Medicine
WOS类目Integrative & Complementary Medicine
WOS记录号WOS:000376946500001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ELEVATED PLUS-MAZE ; ALBIZZIA-JULIBRISSIN ; ANXIETY DISORDERS ; MICE ; RATS ; ANTAGONIST ; WAY-100635 ; GLYCOSIDES ; RESPONSES ; BEHAVIOR
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19943
专题中国科学院心理健康重点实验室
作者单位1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Li, Jian,Liu, Qian-tong,Chen, Yi,et al. Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2016,0(0):1-10.
APA Li, Jian.,Liu, Qian-tong.,Chen, Yi.,Liu, Jie.,Shi, Jin-li.,...&Guo, Jian-you.(2016).Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,0(0),1-10.
MLA Li, Jian,et al."Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 0.0(2016):1-10.
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