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Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression
Tang, Ming-ming1,3; Lin, Wen-juan1,2,4; Pan, Yu-qin1,2; Guan, Xi-ting1,3; Li, Ying-cong1
2016-07-01
Source PublicationPHYSIOLOGY & BEHAVIOR
ISSN0031-9384
SubtypeArticle
Volume161Issue:0Pages:166-173
AbstractOur previous work found that triple central lipopolysaccharide (LPS) administration could induce depressive-like behaviors and increased central pro-inflammatory cytokines mRNA, hippocampal cytokine mRNA in particular. Since several neuroinflammation-associated conditions have been reported to impair neurogenesis, in this study, we further investigated whether the neuroinflammation induced depression would be associated with hippocampal neurogenesis dysfunction. An animal model of depression induced by triple central lipopolysaccharide (LPS) administration was used. In the hippocampus, the neuroinflammatory state evoked by LPS was marked by an increased production of pro-inflammatory cytokines, including interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha. It was found that rats in the neuroinflammatory state exhibited depressive-like behaviors, including reduced saccharin preference and locomotor activity as well as increased immobility time in the tail suspension" test and latency to feed in the novelty suppressed feeding test. Adult hippocampal neurogenesis was concomitantly inhibited, including decreased cell proliferation and newborn cell survival. We also demonstrated that the decreased hippocampal neurogenesis in cell proliferation was significantly correlated with the depressive-like phenotypes of decreased saccharine preference and distance travelled, the core and characteristic symptoms of depression, under neuro inflammation state. These findings provide the first evidence that hippocampal neurogenesis dysfunction is correlated with neuroinflammation-induced depression, which suggests that hippocampal neurogenesis might be one of biological mechanisms underlying depression induced by neruoinflammation. (C) 2016 Elsevier Inc All rights reserved.
KeywordDepressive-like Behavior Neuroinflammation Neurogenesis Pro-inflammatory Cytokine Lipopolysaccharide
DOI10.1016/j.physbeh.2016.04.034
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31170987 ; Key laboratory of Mental Health of Chinese Academy of Sciences(KLMH20142G01) ; 31440045 ; 30770718)
WOS Research AreaPsychology ; Behavioral Sciences
WOS SubjectPsychology, Biological ; Behavioral Sciences
WOS IDWOS:000377310500022
WOS HeadingsSocial Sciences ; Science & Technology ; Life Sciences & Biomedicine
WOS KeywordLIGHT-DARK CYCLE ; ADULT NEUROGENESIS ; TOLERANCE DEVELOPMENT ; SICKNESS BEHAVIOR ; DENTATE GYRUS ; LEARNED HELPLESSNESS ; CELL-PROLIFERATION ; FORCED SWIM ; RAT-BRAIN ; INFLAMMATION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/19946
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.16 Lincui Rd, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Tang, Ming-ming,Lin, Wen-juan,Pan, Yu-qin,et al. Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression[J]. PHYSIOLOGY & BEHAVIOR,2016,161(0):166-173.
APA Tang, Ming-ming,Lin, Wen-juan,Pan, Yu-qin,Guan, Xi-ting,&Li, Ying-cong.(2016).Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression.PHYSIOLOGY & BEHAVIOR,161(0),166-173.
MLA Tang, Ming-ming,et al."Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression".PHYSIOLOGY & BEHAVIOR 161.0(2016):166-173.
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