Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression

doi:10.1016/j.physbeh.2016.04.034

	Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression
	Tang, Ming-ming 1,3; Lin, Wen-juan1,2,4 ; Pan, Yu-qin 1,2; Guan, Xi-ting1,3 ; Li, Ying-cong1
摘要	Our previous work found that triple central lipopolysaccharide (LPS) administration could induce depressive-like behaviors and increased central pro-inflammatory cytokines mRNA, hippocampal cytokine mRNA in particular. Since several neuroinflammation-associated conditions have been reported to impair neurogenesis, in this study, we further investigated whether the neuroinflammation induced depression would be associated with hippocampal neurogenesis dysfunction. An animal model of depression induced by triple central lipopolysaccharide (LPS) administration was used. In the hippocampus, the neuroinflammatory state evoked by LPS was marked by an increased production of pro-inflammatory cytokines, including interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha. It was found that rats in the neuroinflammatory state exhibited depressive-like behaviors, including reduced saccharin preference and locomotor activity as well as increased immobility time in the tail suspension" test and latency to feed in the novelty suppressed feeding test. Adult hippocampal neurogenesis was concomitantly inhibited, including decreased cell proliferation and newborn cell survival. We also demonstrated that the decreased hippocampal neurogenesis in cell proliferation was significantly correlated with the depressive-like phenotypes of decreased saccharine preference and distance travelled, the core and characteristic symptoms of depression, under neuro inflammation state. These findings provide the first evidence that hippocampal neurogenesis dysfunction is correlated with neuroinflammation-induced depression, which suggests that hippocampal neurogenesis might be one of biological mechanisms underlying depression induced by neruoinflammation. (C) 2016 Elsevier Inc All rights reserved.
关键词	Depressive-like Behavior Neuroinflammation Neurogenesis Pro-inflammatory Cytokine Lipopolysaccharide
	2016-07-01
语种	英语
DOI	10.1016/j.physbeh.2016.04.034
发表期刊	PHYSIOLOGY & BEHAVIOR
ISSN	0031-9384
卷号	161 期号:0 页码:166-173
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	LIGHT-DARK CYCLE ; ADULT NEUROGENESIS ; TOLERANCE DEVELOPMENT ; SICKNESS BEHAVIOR ; DENTATE GYRUS ; LEARNED HELPLESSNESS ; CELL-PROLIFERATION ; FORCED SWIM ; RAT-BRAIN ; INFLAMMATION
WOS标题词	Social Sciences ; Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Psychology ; Behavioral Sciences
WOS类目	Psychology, Biological ; Behavioral Sciences
WOS记录号	WOS:000377310500022
资助机构	National Natural Science Foundation of China(31170987 ; Key laboratory of Mental Health of Chinese Academy of Sciences(KLMH20142G01) ; 31440045 ; 30770718)
引用统计	被引频次：72[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19946
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.16 Lincui Rd, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Tang, Ming-ming,Lin, Wen-juan,Pan, Yu-qin,et al. Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression[J]. PHYSIOLOGY & BEHAVIOR,2016,161(0):166-173.
APA	Tang, Ming-ming,Lin, Wen-juan,Pan, Yu-qin,Guan, Xi-ting,&Li, Ying-cong.(2016).Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression.PHYSIOLOGY & BEHAVIOR,161(0),166-173.
MLA	Tang, Ming-ming,et al."Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression".PHYSIOLOGY & BEHAVIOR 161.0(2016):166-173.

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