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Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression
Tang, Ming-ming1,3; Lin, Wen-juan1,2,4; Pan, Yu-qin1,2; Guan, Xi-ting1,3; Li, Ying-cong1
2016-07-01
发表期刊PHYSIOLOGY & BEHAVIOR
ISSN0031-9384
文章类型Article
卷号161期号:0页码:166-173
摘要Our previous work found that triple central lipopolysaccharide (LPS) administration could induce depressive-like behaviors and increased central pro-inflammatory cytokines mRNA, hippocampal cytokine mRNA in particular. Since several neuroinflammation-associated conditions have been reported to impair neurogenesis, in this study, we further investigated whether the neuroinflammation induced depression would be associated with hippocampal neurogenesis dysfunction. An animal model of depression induced by triple central lipopolysaccharide (LPS) administration was used. In the hippocampus, the neuroinflammatory state evoked by LPS was marked by an increased production of pro-inflammatory cytokines, including interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha. It was found that rats in the neuroinflammatory state exhibited depressive-like behaviors, including reduced saccharin preference and locomotor activity as well as increased immobility time in the tail suspension" test and latency to feed in the novelty suppressed feeding test. Adult hippocampal neurogenesis was concomitantly inhibited, including decreased cell proliferation and newborn cell survival. We also demonstrated that the decreased hippocampal neurogenesis in cell proliferation was significantly correlated with the depressive-like phenotypes of decreased saccharine preference and distance travelled, the core and characteristic symptoms of depression, under neuro inflammation state. These findings provide the first evidence that hippocampal neurogenesis dysfunction is correlated with neuroinflammation-induced depression, which suggests that hippocampal neurogenesis might be one of biological mechanisms underlying depression induced by neruoinflammation. (C) 2016 Elsevier Inc All rights reserved.
关键词Depressive-like Behavior Neuroinflammation Neurogenesis Pro-inflammatory Cytokine Lipopolysaccharide
DOI10.1016/j.physbeh.2016.04.034
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(31170987 ; Key laboratory of Mental Health of Chinese Academy of Sciences(KLMH20142G01) ; 31440045 ; 30770718)
WOS研究方向Psychology ; Behavioral Sciences
WOS类目Psychology, Biological ; Behavioral Sciences
WOS记录号WOS:000377310500022
WOS标题词Social Sciences ; Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]LIGHT-DARK CYCLE ; ADULT NEUROGENESIS ; TOLERANCE DEVELOPMENT ; SICKNESS BEHAVIOR ; DENTATE GYRUS ; LEARNED HELPLESSNESS ; CELL-PROLIFERATION ; FORCED SWIM ; RAT-BRAIN ; INFLAMMATION
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/19946
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.16 Lincui Rd, Beijing 100101, Peoples R China
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Tang, Ming-ming,Lin, Wen-juan,Pan, Yu-qin,et al. Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression[J]. PHYSIOLOGY & BEHAVIOR,2016,161(0):166-173.
APA Tang, Ming-ming,Lin, Wen-juan,Pan, Yu-qin,Guan, Xi-ting,&Li, Ying-cong.(2016).Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression.PHYSIOLOGY & BEHAVIOR,161(0),166-173.
MLA Tang, Ming-ming,et al."Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression".PHYSIOLOGY & BEHAVIOR 161.0(2016):166-173.
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